| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In mouse embryos, 1st branchial arch cartilage (Meckel's cartilage) expresses hypoxia-inducible factor, HIF-a, in early stage. Organ-cultured mouse embryonic mandible under hypoxic condition showed microgenia with abnormal Meckl's cartilage. Before beginning of Meckel's cartilage resorption, epidermal-type fatty acid binding protein (E-FABP)-positive septoclasts appeared and involved in resorption of uncalcified matrix of Meckel's cartilage. Septoclasts are shown to play important roles with osteoclast-like chondroclast in rabid regression of Meckel's cartilage before birth.
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