| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The main causative bacteria of pneumonia are Streptococcus pneumoniae and Klebsiella pneumoniae, but it has been reported that periodontal pathogenic bacteria in the oral cavity are frequently detected from pneumonia specimens. In this study, to elucidate the role of periodontopathic bacteria in pneumococcal infection, we focused on nucleases produced by periodontopathic bacteria, analyzed their functions, and elucidated their interactions in the pathophysiology of pneumococcus. It was clarified that the periodontopathic bacterium P. intermedia has high nuclease activity and that the culture supernatant of the periodontopathic bacterium induces the expression of the pneumonia bacillus receptor and increases the attachment of the periodontal pathogenic bacteria to the host cell.
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