| Project/Area Number |
17K11635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kansai Women's Junior College (2022)
Osaka Dental University (2017) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
服部 高子 岡山大学, 医歯薬学総合研究科, 助教 (00228488)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨再生 / 細胞内小器官 / ミトコンドリア / 核 / 軟骨内骨化 / 骨発生 / 軟骨分化 |
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| Outline of Final Research Achievements |
We conducted a comparative study between Sorcin gene-deficient mice and wild-type mice with the aim of elucidating the role of Sorcin, a calcium-binding factor, in the bone formation process and bone metabolism. In the comparison during the embryonic period, it was suggested that KO mice may have increased activity of osteoclasts compared to wild-type mice. Additionally, in the comparison of postnatal mice, there was a tendency for the bone quality to be higher in the KO mice compared to the wild-type mice. Furthermore, it was observed that the apatite orientation tended to be higher in the tibia of KO mice compared to wild-type mice. Based on these results, it became evident that Sorcin is likely to be a factor related to the bone formation process and bone metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
成人における軟骨は生理的再生・増殖の難しい組織であり、病的な増殖を伴った変形性関節炎などは根本的治療薬はない。また、全身的に発現する因子を用いた治療薬は副作用を制御する上で困難を伴う。一方、われわれのSorcinによる軟骨細胞分化制御機構を利用し、病的な軟骨細胞の増殖・分化を調節することで、新たな軟骨疾患治療薬の開発に繋がる可能性がある。
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