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Analysis of the molecular mechanism of the mechanical stress response in osteoblasts through primary cilia

Research Project

Project/Area Number 17K11639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNiigata University

Principal Investigator

Kakihara Yoshito  新潟大学, 医歯学系, 助教 (40379938)

Co-Investigator(Kenkyū-buntansha) 佐伯 万騎男  新潟大学, 医歯学系, 教授 (30273692)
加来 賢  新潟大学, 医歯学系, 准教授 (30547542)
鍵和田 晴美  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (40443204)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨芽細胞 / 一次繊毛 / シャペロン / メカニカルストレス応答 / Pontin / Reptin / メカニカルストレス / 骨芽細胞分化
Outline of Final Research Achievements

In this study, we investigated how osteoblasts, which are involved in bone formation, perceive and respond to external stress. Molecular chaperones are known to be involved in a variety of stress responses. We focused our research on Pontin-Reptin chaperone, which is one of the emerging molecular chaperone. Our results suggest that the Pontin-Reptin mediates between cell cycle and primary cilia formation in osteoblasts.

Academic Significance and Societal Importance of the Research Achievements

繊毛病(ciliopathy)は、繊毛形成因子の欠損によって生じ、腎嚢胞、胆管異常、内臓逆位、多指症、脳梁低形成、網膜色素変性症、頭蓋・骨格異常、糖尿病など多岐にわたる症状を呈する。本研究は、骨形成において重要な働きを担う骨芽細胞における一次繊毛機能の解析を行った。本研究成果は、一次繊毛の機能解明と繊毛病の発症メカニズムの解明やその治療法の開発に貢献するものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Int'l Joint Research] University of Toronto(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Department of Biochemistry/Faculty of Medicine/University of Toronto(カナダ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2017 Research-status Report
  • [Journal Article] ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation2020

    • Author(s)
      Nakata Juri、Akiba Yosuke、Nihara Jun、Thant Lay、Eguchi Kaori、Kato Hiroko、Izumi Kenji、Ohkura Mariko、Otake Masanori、Kakihara Yoshito、Saito Isao、Saeki Makio
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: - Issue: 3 Pages: 547-552

    • DOI

      10.1016/j.bbrc.2020.03.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bmp signaling in molar cusp formation2019

    • Author(s)
      Meguro Fumiya、Porntaveetus Thantrira、Kawasaki Maiko、Kawasaki Katsushige、Yamada Akane、Kakihara Yoshito、Saeki Makio、Tabeta Koichi、Kessler John A.、Maeda Takeyasu、Ohazama Atsushi
    • Journal Title

      Gene Expression Patterns

      Volume: 32 Pages: 67-71

    • DOI

      10.1016/j.gep.2019.04.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fusaspirols A-D, novel oxaspirol derivatives isolated from Fusarium solani B-182019

    • Author(s)
      Ariefta Nanang Rudianto、Nikmawahda Hasna Tazkia、Aboshi Takako、Murayama Tetsuya、Tawaraya Keitaro、Koseki Takuya、Katagi Genta、Kakihara Yoshito、Shiono Yoshihito
    • Journal Title

      Tetrahedron

      Volume: 75 Issue: 10 Pages: 1371-1377

    • DOI

      10.1016/j.tet.2019.01.052

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Systems analysis of the genetic interaction network of yeast molecular chaperones2018

    • Author(s)
      Rizzolo Kamran、Kumar Ashwani、Kakihara Yoshito、Phanse Sadhna、Minic Zoran、Snider Jamie、Stagljar Igor、Zilles Sandra、Babu Mohan、Houry Walid A.
    • Journal Title

      Molecular Omics

      Volume: 14 Issue: 2 Pages: 82-94

    • DOI

      10.1039/c7mo00142h

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping2017

    • Author(s)
      Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 11 Pages: 2735-2748

    • DOI

      10.1016/j.celrep.2017.08.074

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 効率的な歯の移動を目的とした骨代謝促進薬のスクリーニングとその解析2018

    • Author(s)
      柿原嘉人, 中田樹里, Lay Thant, 齋藤 功, 佐伯万騎男
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Analysis of R2TP complex function in oral squamous cell carcinoma2018

    • Author(s)
      Kiguchi T, Kakihara Y, Takagi R, Saeki M
    • Organizer
      IADR/PER General Session & Exhibition
    • Related Report
      2018 Research-status Report
  • [Presentation] ROCK阻害剤の実験的歯の移動への効果2018

    • Author(s)
      中田樹里, 柿原嘉人, 丹原惇,大倉麻里子, 佐伯万騎男, 齋藤功
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ROCK阻害剤の骨代謝への影響とその作用機序の解析2017

    • Author(s)
      中田樹里, 秋葉陽介, 江口香里, 丹原惇, 齋藤功, 柿原嘉人, 佐伯万騎男
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effect of ROCK inhibitor on bone remodeling2017

    • Author(s)
      Nakata J, Akiba Y, Eguchi K, Nihara J, Saito I, Kakihara Y, Saeki M
    • Organizer
      2017 ASBMR Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 新潟大学医歯学総合研究科歯科薬理学分野ホームページ

    • URL

      http://www.dent.niigata-u.ac.jp/pharmacology/pharmacology.html

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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