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The underlying mechanisms of taste and olfactory impairments in Parkinson's disease model mice

Research Project

Project/Area Number 17K11640
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

Sato Hajime  大阪大学, 歯学研究科, 助教 (10432452)

Co-Investigator(Kenkyū-buntansha) 加藤 隆史  大阪大学, 歯学研究科, 教授 (50367520)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords味覚 / 嗅覚 / 農薬 / 中枢神経系 / パーキンソン病 / 嗅球 / 孤束核 / 島皮質 / パーキンソン / 味覚障害 / ドーパミン / 神経科学 / 口腔生理 / 嗅覚障害
Outline of Final Research Achievements

The prodoromal Parkinson’s disease (PD) is associated with aberrations of olfactory and taste function that precede the onset of motor symptoms. However, there are limited studies to clarify the involvement on olfactory and taste impairements of neurodegeneration in central nervous system. We addressed the olfactory and taste impairments in toxic PD model mice. The rotenone-induced mice had attenuated both olfactory and taste functions without any motor dysfunction. The rotenone administration led to the changes of tyrosine hydroxylase immunoreactive (TH-ir) neurons around olfactory bulb (OB), within the nucleus of solitary tract (NTS) and in the bitter taste area of the insular cortex (IC), but to retainments in substantial nigra and ventral tegmental area. Our findings suggest that TH-ir neurons in OB, NTS, and IC are shortly disrupted by the propagation of rotenone through nose-to-brain pathway, resulting in the olfactory and taste impairments without any Parkinson's like symptoms.

Academic Significance and Societal Importance of the Research Achievements

これまで、パーキンソン病 (PD)モデルマウスにおける味覚障害の有無を調べた研究はなく、本研究は、PDモデルマウスにおける味覚障害とその器質的障害をはじめて明らかにした研究であり、PDにおける非運動障害発症機構を解明する点において極めて重要な学術的課題である。本研究成果は、味覚/嗅覚障害の新規治療法の開発や、PDの他の非運動障害の解明に大きく貢献でき、その社会的意義は高い。味覚/嗅覚は、私たちのQuality of life を高めるという点から非常に重要な感覚機能である。本研究成果は、生涯にわたる顎顔面口腔感覚機能保持に対する国民の意識を高め、国民の健康増進に繋がることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Remarks (3 results)

  • [Int'l Joint Research] University of Michigan/School of Dentistry(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cellular mechanisms underlying the rapid depolarization caused by oxygen and glucose deprivation in layer III pyramidal cells of the somatosensory cortex2020

    • Author(s)
      Toyoda H, Kawano T, Sato H, Kato T
    • Journal Title

      Neurosci Res.

      Volume: - Pages: 1-9

    • DOI

      10.1016/j.neures.2020.03.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of GluR Current in Microvilli of Sensory Neurons via Na(+)-Microdomain Coupling among GluR, HCN channel and Na(+)/K(+) Pump.2018

    • Author(s)
      Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y.
    • Journal Title

      Front. Cell. Neurosci.

      Volume: 印刷中 Pages: 113-113

    • DOI

      10.3389/fncel.2018.00113

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nicotinic Activity Depresses Synaptic Potentiation in Layer V Pyramidal Neurons of Mouse Insular Cortex.2018

    • Author(s)
      Sato H, Kawano T, Yin DX, Kato T, Toyoda H.
    • Journal Title

      Neuroscience

      Volume: 379 Pages: 216-218

    • DOI

      10.1016/j.neuroscience.2018.03.044

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological and Morphological Properties of α and γ Motoneurons in the Rat Trigeminal Motor Nucleus2018

    • Author(s)
      Nishimura K, Ohta M, Saito M, et al.
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 12 Pages: 9-9

    • DOI

      10.3389/fncel.2018.00009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Complex and multisensory receptive field characteristics of rat trigeminal ganglion (TG) neurons innervating fungiform papillae2019

    • Author(s)
      Hajime Sato, Archana Kumari, Charlotte M. Mistretta and Robert M. Bradley
    • Organizer
      Oral Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nicotinic activity differentially modulates synaptic plasticity in layers III and VI pyramidal neurons of the mouse insular cortex.2019

    • Author(s)
      Hiroki Toyoda, Hajime Sato, Dong Xu Yin, Takafumi Kato
    • Organizer
      Oral Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モデル動物を用いた味覚障害発症機構の解明2019

    • Author(s)
      佐藤元、尹東旭、豊田博紀、片桐綾乃、加藤隆史
    • Organizer
      第61回 歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 口腔機能発達における間歇的低酸素負荷の影響2019

    • Author(s)
      下田麻央,豊田 博紀,片桐綾乃,佐藤 元,秋山茂久,加藤 隆史
    • Organizer
      第61回 歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パーキンソン病の前駆症状として味覚障害を発症する実験モデル動物の開発2019

    • Author(s)
      佐藤元、尹東旭、豊田博紀、片桐綾乃、加藤隆史
    • Organizer
      第13回三叉神経領域の感覚―運動統合研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Receptive field characteristics of rat trigeminal ganglion neurons.2018

    • Author(s)
      Sato H, Kumari A, Mistretta CM and Bradley RM.
    • Organizer
      Michigan Sensory Sciences Initiative
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ロテノン投与マウスにおける味覚と嗅覚の変化2017

    • Author(s)
      尹東旭、佐藤元、河野奨、松裏豊、豊田博紀、加藤隆史
    • Organizer
      第59回歯科基礎医学会学術大会、松本歯科大学(長野県)
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス鼻腔内へのロテノン投与における嗅覚と味覚の変化2017

    • Author(s)
      尹東旭、佐藤元、河野奨、松裏豊、豊田博紀、加藤隆史
    • Organizer
      三叉神経研究会、ホテル阪急エキスポパーク(大阪府)
    • Related Report
      2017 Research-status Report
  • [Remarks] 大阪大学 大学院歯学研究科 統合機能口腔科学専攻 高次脳口腔機能学講座 口腔生理学教室ホームページ

    • URL

      https://web.dent.osaka-u.ac.jp/phys/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科高次脳口腔機能学講座口腔生理学教室ホームページ

    • URL

      https://web.dent.osaka-u.ac.jp/phys/

    • Related Report
      2018 Research-status Report
  • [Remarks] 大阪大学大学院歯学研究科高次脳口腔機能学講座口腔生理学教室ホームページ

    • URL

      http://web.dent.osaka-u.ac.jp/~phys/

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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