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Regulation in the maintenance of cerebral functions and improvement of cerebral ischemic diseases mediated by parasympathetic vasodilation during mastication

Research Project

Project/Area Number 17K11650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ISHII Hisayoshi  北海道医療大学, 歯学部, 教授 (00275489)

Co-Investigator(Kenkyū-buntansha) 佐藤 寿哉  北海道医療大学, 歯学部, 講師 (30709241)
新岡 丈治  北海道医療大学, 薬学部, 准教授 (10382491)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords副交感神経 / 血流調節 / 脳機能 / 局所温度 / 加齢 / 咀嚼 / 副交感性血流増加 / 三叉神経 / 副交感性脳血流増加 / 脳虚血障害 / 脳賦活 / ペンチレンテトラゾール / 生理学 / 歯学 / 脳・神経
Outline of Final Research Achievements

In the present study, we explored the relationship parasympathetic vasodilation evoked by trigeminal afferent input and cerebral functions, and our results suggest that parasympathetic vasodilations in the cranioorofacial region 1) would be involved in activity of the brain, 2) affect to the local temperature and 3) are inhibited by aging.

Academic Significance and Societal Importance of the Research Achievements

一般に、脳循環の維持には代謝及び内皮性調節系を介する自動調節能(オートレギュレーション)が重要であると考えられている。しかしながら、本研究は、咀嚼に伴う副交感性血流増加の脳血流維持における重要性を明らかにし、口腔摂食機能と密接に関連する新たな脳血流維持機構の可能性を示した点に関して学術的意義は高く、今後のトランスレーショナルな展開は日本の高齢社会で急増する脳虚血疾患の治療や予防の新たなアプローチを築くための礎として重要な社会的意義を有していると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (19 results)

All 2020 2019 2018 2017 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (15 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Effect of the parasympathetic vasodilation on temperature regulation via trigeminal afferents in the orofacial area2020

    • Author(s)
      Ohke H, Sato T, Mito K, Terumitsu M and Ishii H
    • Journal Title

      J Physiol Sci

      Volume: 70 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s12576-020-00749-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between impaired parasympathetic vasodilation and hyposalivation in parotid glands associated with type 2 diabetes mellitus2020

    • Author(s)
      Sato T, Mito K and Ishii H
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 318 Issue: 5 Pages: R940-R949

    • DOI

      10.1152/ajpregu.00016.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions between β-adrenergic vasodilation and cervical sympathetic nerves is mediated by α2-adrenoceptors in the rat masseter muscle2017

    • Author(s)
      Ishii H and Sato T
    • Journal Title

      J Physiol Sci

      Volume: 67 Issue: 6 Pages: 699-709

    • DOI

      10.1007/s12576-016-0499-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Different effects between trigeminal sensory and vagal visceral input on salivary glands blood flow2020

    • Author(s)
      Ratna Ramadahani, Kohei Mito, Toshiya Sato, Hisayoshi Ishii
    • Organizer
      Proceedings of the 97th Annual Meeting of The Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Difference between somatosensory and gustatory input on parasympathetic increase in blood flow in rat three major salivary glands2020

    • Author(s)
      Toshiya Sato, Ratna Ramadahani, Kohei Mito, Hisayoshi Ishii
    • Organizer
      Proceedings of the 97th Annual Meeting of The Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咀嚼筋の三叉―自律神経反射を介する血流動態の加齢による変調とそのメカニズム2019

    • Author(s)
      三戸浩平、佐藤寿哉、Ramadhani Ratna、石井久淑
    • Organizer
      第99回北海道医学大会生理系分科会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咀嚼筋の三叉―自律神経反射を介する血流動態の加齢による変調とそのメカニズム2019

    • Author(s)
      三戸浩平、佐藤寿哉、Ramadhani Ratna、石井久淑
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット三大唾液腺の血流動態に与える体性感覚と味覚入力の効果の違い2019

    • Author(s)
      佐藤寿哉、Ramadhani Ratna、三戸浩平、石井久淑
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hyposalivation and impaired parasympathetic vasodilation in parotid glands with type 2 diabetes mellitus2019

    • Author(s)
      Sato T, Mito K and Ishii H
    • Organizer
      Federation of the Asian and Oceanian Physiological Societies in conjunction with The 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Age-related changes in hemodynamics in orofacial area and their mechanisms2019

    • Author(s)
      Mito K, Sato T and Ishii H
    • Organizer
      Federation of the Asian and Oceanian Physiological Societies in conjunction with The 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット唾液腺の反射性唾液分泌における副交感神経性血流増加反応の関与2018

    • Author(s)
      佐藤寿哉、三戸浩平、石井久淑
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 老化に伴う顎顔面領域の血流動態の変調とそのメカニズム2018

    • Author(s)
      三戸浩平、佐藤寿哉、石井久淑
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 老化に伴う顎顔面領域の血流動態の変調とそのメカニズム2018

    • Author(s)
      三戸浩平、佐藤寿哉、石井久淑
    • Organizer
      第98回北海道医学大会生理系分科会
    • Related Report
      2018 Research-status Report
  • [Presentation] 2型糖尿病が唾液腺における副交感神経性血管拡張反応に与える影響2017

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第97回北海道医学大会生理系分科会
    • Related Report
      2017 Research-status Report
  • [Presentation] 2型糖尿病が唾液腺における副交感神経性血管拡張反応に与える影響2017

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 三叉神経入力で生じる口腔内及び口腔外組織の血流動態とサーモレギュレーションにおける相違点2017

    • Author(s)
      石井久淑、佐藤寿哉
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Age-related attenuation of parasympathetic nerve-evoked blood flow response in the orofacial area of rats2017

    • Author(s)
      Hirohata Y, Saito T, Sato T and Ishii H
    • Organizer
      Proceedings of the 95th Annual Meeting of The Physiological Society of Japan
    • Related Report
      2017 Research-status Report
  • [Presentation] Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α2-adrenoceptors in the rat masseter muscle2017

    • Author(s)
      Ishii H and Sato T
    • Organizer
      Proceedings of the 95th Annual Meeting of The Physiological Society of Japan
    • Related Report
      2017 Research-status Report
  • [Remarks] 北海道医療大学歯学部口腔生物学系生理学分野

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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