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Development of a mouthpiece that does not affect the effect of dental alloys on the 3D dose distribution of heavy particle beams and its distribution

Research Project

Project/Area Number 17K11664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

Katsura Kouji  新潟大学, 医歯学総合病院, 講師 (30283021)

Co-Investigator(Kenkyū-buntansha) 水野 秀之  国立研究開発法人量子科学技術研究開発機構, QST病院, 主幹研究員 (70421823)
伊川 裕明  国立研究開発法人量子科学技術研究開発機構, QST病院 治療診断部, 医長 (00793928)
宇都宮 悟  新潟大学, 医歯学系, 准教授 (50570868)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords歯科用金属 / 頭頸部放射線治療 / 重粒子線治療 / 歯科用マウスピース / 線量強度解析 / 歯科用スペーサー / 線量強度変化 / 粒子線治療 / 歯科用合金 / マウスピース / 放射線治療補助器具 / 放射線粘膜炎 / 下顎骨壊死 / 急性有害事象 / 晩期有害事象 / 放射線 / 高精度放射線治療 / 歯科用装置
Outline of Final Research Achievements

We have clarified the relationship ofhe dose distribution in heavy ion radiotherapy between the dental metals and the mouthpiece. As the results, the their impact of dose distribution in heavy ion radiotherapy was clarified. In addition, this study shows that mouthpiese measures against dental metal is more benefical to the removing dental metal before radiotherapy.

Academic Significance and Societal Importance of the Research Achievements

重粒子線治療では粒子線の優れた物理学的特性を担保するために、治療前に口腔内のすべての歯科用合金は除去される。この理由は、金属アーチファクトにより阻止能比をCT値から算出できず、CTシミュレーション上で歯科用合金の線量分布への影響が予測できないからである。実測値から歯科用合金の種類による阻止能比が明らかにできれば、治療前に口腔内のすべての歯科用合金を除去する必要がなくなり、医療費の抑制、重粒子治療の効率化、新たな重粒子線治療の創出が可能になり意義あることである。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (6 results) Remarks (1 results)

  • [Journal Article] A cost-minimization analysis of measures against metallic dental restorations for head and neck radiotherapy2021

    • Author(s)
      Katsura Kouji、Soga Yoshihiko、Zenda Sadatomo、Nishi Hiromi、Soga Marie、Usubuchi Masatoshi、Mitsunaga Sachiyo、Tomizuka Ken、Konishi Tetsuhito、Yatsuoka Wakako、Ueno Takao、Aragaki Tadanobu、Hayashi Takafumi
    • Journal Title

      Journal of Radiation Research

      Volume: 62 Issue: 2 Pages: 374-378

    • DOI

      10.1093/jrr/rrab003

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor2019

    • Author(s)
      Ikawa Hiroaki , Koto Masashi , K. Ebner Daniel , Hayashi Kazuhiko , Takagi Ryo , Tonogi Morio , Nomura Takeshi , Tsuji Hiroshi , Kamada Tadashi
    • Journal Title

      Advances in Radiation Oncology

      Volume: 4 Issue: 1 Pages: 15-19

    • DOI

      10.1016/j.adro.2018.08.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A custom-made mouthpiece incorporating tongue depressors and elevators to reduce radiation-induced tongue mucositis during carbon-ion radiation therapy for head and neck cancer2018

    • Author(s)
      Ikawa Hiroaki、Koto Masashi、Ebner Daniel K.、Takagi Ryo、Hayashi Kazuhiko、Tsuji Hiroshi、Kamada Tadashi
    • Journal Title

      Practical Radiation Oncology

      Volume: 8 Issue: 2 Pages: e27-e31

    • DOI

      10.1016/j.prro.2017.10.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SY13-3Special prosthetic device for head and neck radiotherapy based on scientific evidence2017

    • Author(s)
      Katsura Kouji、Utsunomiya Satoru、Kushima Naotaka、Abe Eisuke、Aoyama Hidefumi、Hayashi Takafumi
    • Journal Title

      Annals of Oncology

      Volume: 28 Pages: ix36-ix36

    • DOI

      10.1093/annonc/mdx583

    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cost estimation study of measures against metallic dental restorations for head and neck radiotherapy in Japan2021

    • Author(s)
      Katsura K, Soga Y, Zenda S, Nishi H, Soga M, Usubuchi M, Mitsunaga S, Tomizuka K, Konishi T, Yatsuoka W, Ueno T, Aragaki T, Hayashi T
    • Organizer
      The 2021 MASCC/ISOO Annual Meeting on Supportive Care in Cancer
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 頭頸部強度変調放射線治療における金属アーチファクトの輪郭抽出時間への影響2021

    • Author(s)
      勝良剛詞,棚邊哲史,中野 永,坂井まどか,宇都宮悟,太田 篤,海津元樹,曽我麻里恵,林 孝文
    • Organizer
      日本放射線腫瘍学会第34回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 重粒子線治療における正常組織圧排用スペーサーと歯科用合金の物理学的特性の解明2021

    • Author(s)
      勝良剛詞, 水野秀之, 宇都宮悟
    • Organizer
      2020年度HIMAC共同利用研究成果発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Cost estimation study of measures against metallic dental restorations for head and neck radiotherapy in Japan2021

    • Author(s)
      Kouji Katsura
    • Organizer
      2021 MASCC/ISOO Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭頸部放射線治療における金属歯冠修復物対策の経済評価2020

    • Author(s)
      勝良剛詞
    • Organizer
      日本がん口腔支持療法学会第6回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頭頸部放射線治療における論拠に基づいた放射線治療用特殊補綴装置2017

    • Author(s)
      勝良剛詞、宇都宮悟、久島尚隆、阿部英輔、青山英史、林 孝文
    • Organizer
      第15回 日本臨床腫瘍学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A study on backscatter radiation from dental alloys and a protective device during radiotherapy2017

    • Author(s)
      Katsura K, Utsunomiya S, Soga M, Nakayama M, Kobayashi T, Hayashi T
    • Organizer
      21th International Congress of Dental and Maxillofacial Radiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 2020年度量子医科学研究所重粒子線がん治療装置等共同利用研究報告書2021

    • Author(s)
      勝良剛詞, 水野秀之, 宇都宮悟
    • Total Pages
      224
    • Publisher
      量子科学技術研究開発機構
    • Related Report
      2021 Annual Research Report
  • [Book] がん治療に伴う粘膜障害マネジメントの手引き 2020年版2020

    • Author(s)
      日本がんサポーティブケア学会、日本がん口腔支持療法学会
    • Total Pages
      192
    • Publisher
      金原出版
    • ISBN
      9784307204101
    • Related Report
      2019 Research-status Report
  • [Book] がん治療で起こる副作用・合併症の治療法と薬剤開発2018

    • Author(s)
      勝良剛詞、東 光久
    • Total Pages
      508
    • Publisher
      技術情報協会
    • Related Report
      2018 Research-status Report
  • [Book] 第5章.治療前のスクリーニングと管理、がん口腔支持療法 多職種連携によるがん患者の口腔内管理2017

    • Author(s)
      櫻井彩,室美里,小崎弘貴,山中玲子,吉冨愛子,曽我賢彦,勝良剛詞
    • Total Pages
      315
    • Publisher
      永末書店
    • ISBN
      9784816013287
    • Related Report
      2017 Research-status Report
  • [Book] 第10章.放射線療法の合併症概説、がん口腔支持療法 多職種連携によるがん患者の口腔内管理2017

    • Author(s)
      町田達哉,曽我賢彦,勝良剛詞
    • Total Pages
      315
    • Publisher
      永末書店
    • ISBN
      9784816013287
    • Related Report
      2017 Research-status Report
  • [Book] 第12章.顎骨の放射線照射後の骨壊死(放射線骨壊死)、がん口腔支持療法 多職種連携によるがん患者の口腔内管理2017

    • Author(s)
      中村心,曽我賢彦,勝良剛詞
    • Total Pages
      315
    • Publisher
      永末書店
    • ISBN
      9784816013287
    • Related Report
      2017 Research-status Report
  • [Remarks] 新潟大学 研究者総覧

    • URL

      http://researchers.adm.niigata-u.ac.jp/html/484_ja.html?k=%E5%8B%9D%E8%89%AF%E5%89%9B%E8%A9%9E

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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