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Analysis of the role of pneumococcal interactions with glycosaminoglycans in the inflammatory response and establishment of infection

Research Project

Project/Area Number 17K11666
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka University

Principal Investigator

Yujiro Hirose  大阪大学, 歯学研究科, 特任助教 (90788407)

Co-Investigator(Kenkyū-buntansha) 山口 雅也  大阪大学, 歯学研究科, 助教 (00714536)
川端 重忠  大阪大学, 歯学研究科, 教授 (50273694)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺炎球菌 / 髄膜炎 / 脳微小血管内皮細胞 / 付着 / 侵入 / Ccs4 / 病原因子 / 糖鎖 / グリコサミノグリカン / 血液脳関門 / 付着・侵入
Outline of Final Research Achievements

Streptococcus pneumoniae is a major pathogen that causes pneumonia and meningitis. Neisseria meningitidis, another pathogen causing meningitis, promotes the survival in human serum through an Arginine-rich region of its lipoprotein. S. pneumoniae competence-induced protein Ccs4 showed similarities with the Arginine-rich region.
We constructed ccs4 mutant strain of S. pneumoniae wild-type strain. The deletion of ccs4 decreased the adhesion and invasion against human brain microvascular endothelial cells. There were no significant differences between the survival rate of the ccs4 mutant and wild-type strains in mouse blood. In a mouse sepsis model, ccs4 mutant strain-infected mice showed a significantly prolonged survival time as compared to wild-type strain-infected mice.
These results indicated that Ccs4 is involved in pneumococcal adhesion to and invasion of host endothelial cells and contributed to the virulence of S. pneumoniae.

Academic Significance and Societal Importance of the Research Achievements

肺炎球菌は口や喉から分離される病原菌である。全身に伝播した場合、髄膜炎や敗血症などの致死性が高い疾患を引き起こす。高齢者人口の増加や薬剤耐性菌の出現に伴い、肺炎球菌による感染症は社会的問題になっている。同菌に対しては、莢膜多糖を抗原とする多価ワクチンが使用されているが、免疫の持続時間や血清型のカバーなどの問題があり、新規治療法の開発が望まれている。
本研究では、肺炎球菌が髄膜炎発症に際して血液脳関門を突破するときに利用する新規分子として、形質転換誘導性タンパク質Ccs4を発見した。発症機構に関与する菌分子の同定は、予防効果の高い治療法の確立に道を開く可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (67 results)

All 2020 2019 2018 2017

All Journal Article (15 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 14 results,  Open Access: 13 results) Presentation (52 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results)

  • [Journal Article] Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency.2020

    • Author(s)
      Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S.
    • Journal Title

      Mol Microbiol

      Volume: 113 Issue: 1 Pages: 173-189

    • DOI

      10.1111/mmi.14408

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine,rabbit and porcine serum albumins.2020

    • Author(s)
      Sankar S,Yamaguchi M,Kawabata S,Ponnuraj K.
    • Journal Title

      Protein J.

      Volume: 39 Issue: 1 Pages: 1-9

    • DOI

      10.1007/s10930-019-09875-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria that predominate in the oral cavity and upper airways2019

    • Author(s)
      Domon Hisanori、Hiyoshi Takumi、Maekawa Tomoki、Yonezawa Daisuke、Tamura Hikaru、Kawabata Shigetada、Yanagihara Katsunori、Kimura Osamu、Kunitomo Eiji、Terao Yutaka
    • Journal Title

      Microbiology and Immunology

      Volume: 63 Issue: 6 Pages: 213-222

    • DOI

      10.1111/1348-0421.12688

    • NAID

      40021941640

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA.2019

    • Author(s)
      Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S.
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 9 Pages: 301-301

    • DOI

      10.3389/fcimb.2019.00301

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surface pre-reacted Glass filler contributes to tertiary dentin Formation through a Mechanism different than that of hydraulic calcium-silicate cement.2019

    • Author(s)
      Okamoto M, Ali M, Komichi S, Watanabe M, Huang H, Ito Yuki, Miura J, Hirose Y, Mizuhira M, Takahashi Y, Okuzaki D, Kawabata S, Imazato S, Hayashi M.
    • Journal Title

      Journal of Clinical Medicine.

      Volume: 8 Issue: 9 Pages: 11-11

    • DOI

      10.3390/jcm8091440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis.2019

    • Author(s)
      Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Appl Environ Microbiol

      Volume: 85 Issue: 21

    • DOI

      10.1128/aem.01428-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae2019

    • Author(s)
      Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Nakano K, Kawabata S.
    • Journal Title

      Commun Biol

      Volume: 2 Issue: 1 Pages: 96-96

    • DOI

      10.1038/s42003-019-0340-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells.2018

    • Author(s)
      Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y.
    • Journal Title

      Microbiol Immuno

      Volume: 62 Issue: 10 Pages: 617-623

    • DOI

      10.1111/1348-0421.12647

    • NAID

      40021702611

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pneumoniae surface adhesin PfbA and its interaction with erythrocytes and hemoglobin2018

    • Author(s)
      Radhakrishnan D, Yamaguchi M, Kawabata S, Ponnuraj K.
    • Journal Title

      Int Biol Macromol

      Volume: 120 Pages: 135-143

    • DOI

      10.1016/j.ijbiomac.2018.08.080

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia2018

    • Author(s)
      Domon Hisanori、Nagai Kosuke、Maekawa Tomoki、Oda Masataka、Yonezawa Daisuke、Takeda Wataru、Hiyoshi Takumi、Tamura Hikaru、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Front Immunol

      Volume: 印刷中 Pages: 732-732

    • DOI

      10.3389/fimmu.2018.00732

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 42018

    • Author(s)
      Nagai Kosuke、Domon Hisanori、Maekawa Tomoki、Oda Masataka、Hiyoshi Takumi、Tamura Hikaru、Yonezawa Daisuke、Arai Yoshiaki、Yokoji Mai、Tabeta Koichi、Habuka Rie、Saitoh Akihiko、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Cell Immunol

      Volume: 325 Pages: 14-22

    • DOI

      10.1016/j.cellimm.2018.01.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals2018

    • Author(s)
      Hirose Y, Funahashi Y, Matsukawa Y, Majima T, Yamaguchi M, Kawabata S, Gotoh M, Yamamoto T
    • Journal Title

      Cytotherapy

      Volume: 20 Issue: 4 Pages: 589-591

    • DOI

      10.1016/j.jcyt.2018.02.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Composition of salivary microbiota in elderly subjects2018

    • Author(s)
      Ogawa Taiji、Hirose Yujiro、Honda-Ogawa Mariko、Sugimoto Minami、Sasaki Satoshi、Kibi Masahito、Kawabata Shigetada、Ikebe Kazunori、Maeda Yoshinobu
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 414-414

    • DOI

      10.1038/s41598-017-18677-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems2017

    • Author(s)
      Yamaguchi Masaya、Nakata Masanobu、Sumioka Ryuichi、Hirose Yujiro、Wada Satoshi、Akeda Yukihiro、Sumitomo Tomoko、Kawabata Shigetada
    • Journal Title

      Virulence

      Volume: 8 Issue: 8 Pages: 1516-1524

    • DOI

      10.1080/21505594.2017.1328333

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 口腔細菌叢から健康を考える2017

    • Author(s)
      小川 泰治,広瀬 雄二郎,本多 真理子
    • Journal Title

      Medical Science Digest

      Volume: 43 Pages: 561-563

    • Related Report
      2017 Research-status Report
  • [Presentation] 肺炎球菌の菌体表層タンパク質群に着目した病態形成機構の解明.2020

    • Author(s)
      山口雅也.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 肺炎球菌の菌体表層タンパク質BgaAが病態形成に果たす役割.2020

    • Author(s)
      竹村萌,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pyogenes emm 89型の侵襲性に寄与する因子の検索.2020

    • Author(s)
      広瀬雄二郎,山口雅也,秋山徹,竹本訓彦,奥野ルミ,山口貴弘,大塚仁,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザに続発する細菌性肺炎の発症におけるGP96の機能解析.2020

    • Author(s)
      住友倫子,中田匡宣,長瀬賢史,高原悠樹,山口雅也,岡本成史,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] mRNAサーモセンサーにより制御される化膿レンサ球菌の温度感受性線毛産生.2020

    • Author(s)
      中田匡宣.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 化膿レンサ球菌のアルギニン代謝系は皮膚上で病原性発揮機構に寄与する.2019

    • Author(s)
      広瀬雄二郎,山口雅也,住友倫子,川端重忠.
    • Organizer
      第93回日本感染症学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 化膿レンサ球菌による温度依存性の線毛産生(Temperature-dependent pilus production of Streptococcus pyogenes).2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Influenza virus-induced dysfunction of pulmonary epithelial barrier promotes secondary bacterial infection.2019

    • Author(s)
      住友倫子.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Streptococcus pyogenes のアルギニン代謝系が病変形成に果たす役割の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,毛利泰士,後藤花奈,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Component analysis of cell-wall anchored pili in Streptococcus sanguinis.2019

    • Author(s)
      李怡萱,中田匡宣,岡橋暢夫,山口雅也,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of two-component regulatory system TCS08 in pneumococcal pneumonia pathogenesis.2019

    • Author(s)
      本多-小川真理子,住友倫子,Dalia Hamd,毛利泰士,山口雅也,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺炎球菌の β-ガラクトシダーゼ BgaA の進化的な保存性と病態に 果たす役割の解析.2019

    • Author(s)
      竹村萌,山口雅也,後藤花奈,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 進化的な保存性の評価に基づく肺炎球菌の病原因子の探索.2019

    • Author(s)
      山口雅也,後藤 花奈,竹村 萌,広瀬 雄二郎,住友 倫子,中田 匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 日本における劇症型感染症由来Streptococcus pyogenes emm 89型の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,奥野ルミ,秋山徹,菅原庸,浜田茂幸,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Two-component regulatory system TCS08 contributes to pathogenesis in pneumococcal pneumonia.2019

    • Author(s)
      Sumitomo T,Hamd DT,Honda-Ogawa M,Mori Y,Yamaguchi M,Nakata M,Kawabata S.
    • Organizer
      ASM Microbe 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺炎球菌のβ-ガラクトシダーゼBgaAは敗血症の病原因子として働く.2019

    • Author(s)
      竹村萌,山口雅也,住友倫子,中田匡宣,鵜澤成一,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pneumoniae のコリン結合タンパク質CbpJおよびCbpLの機能解析.2019

    • Author(s)
      後藤花奈,山口雅也,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 宿主―細菌相互作用による肺炎重症化メカニズム解析.2019

    • Author(s)
      土門久哲,永井康介,山口雅也,川端重忠,寺尾豊.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺炎球菌の菌体表層タンパク質PfbAが自然免疫系に対して果たす役割の解明.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザに続発する細菌性肺炎の重症化機構.2019

    • Author(s)
      川端重忠.
    • Organizer
      第73回日本細菌学会東北支部総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] マウス壊死性筋膜炎モデルの感染局所におけるStreptococcus pyogenesの遺伝子発現解析.2019

    • Author(s)
      花田知己,広瀬雄二郎,山口雅也,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザ感染によるGP96シャペロンの活性化は肺炎球菌の肺胞上皮細胞への付着を亢進させる.2019

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Restoration of intact nra into serotype M18 Streptococcus pyogenes restored thermosensitive pilus production.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Okahashi N,Kawabata S.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pyogenesは低グルコース環境においてアルギニン代謝依存的に遺伝子発現を変動させる.2019

    • Author(s)
      広瀬雄二郎,山口雅也,花田知己,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeは種特異的なタンパク質PfbAにより過剰な免疫応答を伴う宿主の死亡を抑制する.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 温度感受性転写因子の翻訳効率に依存する化膿レンサ球菌の線毛発現.2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Restoration of transcriptional regulator nra in serotype M18 Streptococcus pyogenes leads to phenotypic change.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Kawabata S.
    • Organizer
      第7回口腔微生物研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of pneumococcal virulence factors based on selective pressure analysis.2019

    • Author(s)
      山口雅也.
    • Organizer
      2019年「先進ゲノム支援」拡大班会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] S-PRGセメントによる第三象牙質形成機序の解明2019

    • Author(s)
      岡本基岐,小道俊吾,渡邉昌克,黄海玲,伊藤勇紀,三浦治郎,広瀬雄二郎,水平学,高橋雄介, 川端重忠,今里聡,林美加子
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Streptococcus pneumoniaeのコリン結合タンパク質群の系統関係と種内における選択圧の解析2018

    • Author(s)
      山口雅也,後藤花奈,広瀬雄二郎,竹村萌,住友倫子,中田匡宣,川端重忠
    • Organizer
      第6回口腔微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] PilX is a pilus subunit of Streptococcus sanguinis that contributes to biofilm formation2018

    • Author(s)
      李怡萱, 中田匡宣, 山口雅也, 住友倫子, 川端重忠
    • Organizer
      第6回口腔微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] ミティス群レンサ球菌が産生する過酸化水素はマスト細胞の細胞死を誘導し,脱顆粒を抑制する2018

    • Author(s)
      岡橋暢夫, 中田匡宣, 広瀬雄二郎, 桑田啓貴, 川端重忠
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Component analysis of cell-wall anchored pili of Streptococcus sanguinis2018

    • Author(s)
      李怡萱, 中田匡宣, 岡橋暢夫, 山口雅也, 住友倫子, 川端重忠
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺炎球菌性の重症化メカニズム解析 -新規肺炎制御法への展開-2018

    • Author(s)
      土門久哲,永井康介,前川知樹,山口雅也,川端重忠,寺尾 豊
    • Organizer
      第6回口腔微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質構造解析2018

    • Author(s)
      東孝太郎,武部克己,山口雅也,住友倫子,中田匡宣,鈴木守,川端重忠.
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 分子進化解析に基づく肺炎球菌のコリン結合タンパク質群の選択圧の評価2018

    • Author(s)
      山口雅也,後藤花奈,広瀬雄二郎,竹村萌,住友倫子,中田匡宣,川端重忠
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 化膿レンサ球菌のアルギニンデイミナーゼArcAは低グルコース環境下で病原因子の発現に寄与する2018

    • Author(s)
      広瀬雄二郎, 山口雅也, 毛利泰士, 後藤花奈, 住友倫子, 中田匡宣, 川端重忠
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of novel pneumococcal virulence factor CbpJ by molecular evolutional analysis2018

    • Author(s)
      Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Kawabata S.
    • Organizer
      Gordon Research Conference.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniaeのCbpJは肺炎において好中球からの殺菌回避に寄与する2018

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第50回レンサ球菌研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] インフルエンザウイルスとStreptococcus sanguinis の共感染による肺炎発症メカニズムの解析2018

    • Author(s)
      長瀬賢史, 住友倫子, 中田匡宣, 川端重忠, 岡本成史
    • Organizer
      第50回レンサ球菌研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pneumococcal Ccs4 facilitates its invasion into brain tissue and develops meningitis2018

    • Author(s)
      Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S
    • Organizer
      American Society for Microbiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺炎球菌のジンクメタロプロテアーゼZmpCが髄膜炎発症に果たす役割の解明2018

    • Author(s)
      山口雅也,中田匡宣,住友倫子,川端重忠
    • Organizer
      第38回近畿腸管微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺炎球菌はPfbAを介して好中球による殺菌を回避する2018

    • Author(s)
      山口雅也, 広瀬雄二郎, 後藤花奈, 住友倫子, 川端重忠
    • Organizer
      第92回日本感染症学会総会.
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺炎球菌のコリン結合タンパク質CbpJは好中球による殺菌の回避に働く2018

    • Author(s)
      後藤花奈,山口雅也,川端重忠,仲野和彦
    • Organizer
      第56回小児歯科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Streptococcus pyogenesが産生するArcAは皮膚病変形成に寄与する2018

    • Author(s)
      広瀬 雄二郎,山口 雅也,毛利 泰士,後藤 花奈,住友 倫子,中田 匡宣,川端 重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺炎球菌のコリン結合タンパク質 CbpJ および CbpLの肺炎発症における役割の解析2018

    • Author(s)
      後藤 花奈,山口 雅也,広瀬 雄二郎,住友 倫子,中田 匡宣,川端 重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺炎球菌の β-ヘリックス構造タンパク質 PfbA を介した貪食回避機構の解析2018

    • Author(s)
      山口 雅也,広瀬 雄二郎,後藤 花奈,竹村 萌,住友 倫子,中田 匡宣,川端 重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Streptococcus pneumoniae Ccs4は脳血管内皮細胞への付着・侵入を促進する病原因子である2017

    • Author(s)
      広瀬 雄二郎,山口 雅也,後藤 花奈,住友 倫子,中田 匡宣,川端 重忠
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Streptococcus pneumoniaeのコリン結合タンパク質CbpJは肺炎発症における病原因子として働く2017

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺炎球菌のメタロプロテアーゼZmpCは中枢系への菌の侵人を抑制する2017

    • Author(s)
      山口 雅也,広瀬 雄二郎,後藤 花奈,竹村 萌,住友 倫子,中田 匡宣,川端 重忠
    • Organizer
      第91回日本感染症学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Streptococcus pneumoniae evades host innate immunity through parallel β-helix protein PfbA2017

    • Author(s)
      Yamaguchi M, Hirose Y, Goto K, Sumitomo T, Nakata M, Kawabata S
    • Organizer
      20th Lancefield International Symposium on Streptococci and Streptococcal Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniae Ccs4 involved in penetration across blood-brain barrier and virulence in meningitis2017

    • Author(s)
      Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S
    • Organizer
      20th Lancefield International Symposium on Streptococci and Streptococcal Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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