Elucidation of the mechanism of irradiated tooth germ formation disorder
| Project/Area Number |
17K11687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
Iwata Hiroshi 日本歯科大学, 生命歯学部, 准教授 (40328860)
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| Co-Investigator(Kenkyū-buntansha) |
井出 吉昭 日本歯科大学, 生命歯学部, 准教授 (70409225)
深田 哲也 日本歯科大学, 生命歯学部, 助教 (20386254)
中原 貴 日本歯科大学, 生命歯学部, 教授 (10366768)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 放射線被爆 / 歯胚 / 歯胚発生 / 放射線被曝 / 放射線治療 / 小児白血病 / 歯冠 / 放射線 / マウス / 発生 |
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| Outline of Final Research Achievements |
In order to elucidate the mechanism of tooth germ formation disorder due to irradiation exposure, we examined an irradiation experimental model on embryonic mice. We investigated a method of locally irradiating the abdomen of pregnant mice (in vivo), a method of temporarily removing the fetus from the uterus of the pregnant mouse (in vivo) and irradiating it back to the mother, and an organ culture method (in vitro).In vivo experiments, there were many variations in control mice due to radiation damage in pregnant and fetal mice and the effects of experimental techniques. Irradiation experiments using the organ culture method were considered to be suitable for this study.
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| Academic Significance and Societal Importance of the Research Achievements |
小児期の放射線被曝は矮小歯、エナメル質減形成、歯胚の無形成（石灰化不全）などが生じると報告されている。今までに実験動物を扱い、放射線が歯の発生に与える影響について報告されているが、歯の形成障害のメカニズムを解明したものではない。
本研究では、放射線被曝による歯冠形成障害のメカニズムを明らかにすることを目指し、その実験モデルの開発を行う。本研究を行うことにより、放射線被曝による歯胚形成障害の予防法や治療法の開発に寄与できると考える。
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Report
(5 results)
Research Products
(42 results)
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[Journal Article] Hmga2 regulation of tooth formation and association with Sox2 and Nanog expression2019
Author(s)
Kodama Y, Harinath D, Mihara-Tomiyama N, Tominaga N, Ide Y, Nakahara T, Maeda M, Igarashi M, D'Armiento J, Chada K, Imai K
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Journal Title
Biochem Biophys Res Commun
Volume: 509
Issue: 4
Pages: 1008-1014
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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