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Foundation of medical treatment for tongue cancer by the regulation of metal-binding protein

Research Project

Project/Area Number 17K11689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionMatsumoto Dental University

Principal Investigator

Sogawa Norio  松本歯科大学, 歯学部, 教授 (30236153)

Co-Investigator(Kenkyū-buntansha) 今村 泰弘  松本歯科大学, 歯学部, 講師 (00339136)
十川 千春  岡山大学, 医歯薬学総合研究科, 准教授 (10253022)
落合 隆永  朝日大学, 歯学部, 准教授 (20410417)
宮崎 育子  岡山大学, 医歯薬学総合研究科, 助教 (40335633)
荒 敏昭  松本歯科大学, 歯学部, 准教授 (90387423)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsmetallothionein / 舌癌 / メタロチオネイン / 口腔がん / 亜鉛 / MT-4 / 亜鉛シグナル / 亜鉛トランスポーター / 舌癌細胞 / 癌遺伝子 / 癌抑制遺伝子
Outline of Final Research Achievements

In order to construct a foundation of medical treatment for tongue cancer, it was investigated the influence of the regulation of MT-4 expression on cancer cell growth, an intracellular zinc ion regulating protein expressed specifically in squamous epithelium. Moreover, it was explored the inducers of MT-4 gene expression and intracellular interacted factor with MT-4 protein.
As the results, it was revealed that the zinc sensitivity was associated with cell proliferation of cancer, and zinc sensitive cancer cells decreased the cell proliferation by MT-4 gene introduction. Moreover, it was suggested that MT-4 gene expression was induced by glucocorticoids and MT-4 was related with gene expression by itself.

Academic Significance and Societal Importance of the Research Achievements

本研究の推進により,細胞内亜鉛濃度の維持・調節に重要なMT,特にMT-4の発現を制御することで亜鉛感受性扁平上皮癌細胞の増殖制御が可能であることが明らかになった。これは,細胞内亜鉛濃度調節タンパク質のアイソフォーム別機能とそれらの発現調節という新たな視点から,扁平上皮癌の新規治療法の基盤を構築する上で,重要な知見であると考える。特に,治療対象とする口腔扁平上皮癌は,歯科・口腔外科領域において非常に重要な疾患であり,また,外部からの治療アプローチが可能であるという特性も備えていることから,遺伝子導入など新たなる機序による抗悪性腫瘍薬開発に繋がる可能性を示す研究結果であると考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3.2020

    • Author(s)
      Sogawa C, Eguchi T, Tran MT, Ishige M, Trin K, Okusha Y, Taha EA, Lu Y, Kawai H, Sogawa N, Takigawa M, Calderwood SK, Okamoto K, Kozaki KI.
    • Journal Title

      Cancers (Basel).

      Volume: 12(2). Issue: 2 Pages: 523-523

    • DOI

      10.3390/cancers12020523

    • NAID

      120006840778

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability.2019

    • Author(s)
      Sogawa C, Eguchi T, Okusha Y, Ono K, Ohyama K, Iizuka M, Kawasaki R, Hamada Y, Takigawa M, Sogawa N, Okamoto K, and Kozaki K.
    • Journal Title

      Tissue Engineering Part A

      Volume: in press Issue: 19-20 Pages: 1413-1425

    • DOI

      10.1089/ten.tea.2018.0348

    • NAID

      120006788780

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] オルガノイドを応用したドラッグリポジショニング開発2019

    • Author(s)
      十川千春,江口傑徳,Tran Tien Manh,石毛真行,河合穂高,奥舎有加,中野敬介, 十川紀夫,小崎健一,岡元邦彰
    • Organizer
      第40回岡山歯学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Drug repositioning using three-dimensional, MMP9 promoter activity-based anticancer drug screening2019

    • Author(s)
      Chiharu Sogawa, Takanori Eguchi, Yuka Okusha, Kazumi Ohyama, Kisho Ono, Norio Sogawa, Kuniaki Okamoto
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Establishment of high metastatic evolved clone of adenocarcinoma cells with Mmp9 promoter-driven fluorescence reporter2018

    • Author(s)
      Chiharu Sogawa, Takanori Eguchi, Yuka Okusha, Keisuke Nakano, Yuri Namba, Kazumi Ohyama, Norio Sogawa, Ken-ichi Kozaki, Kuniaki Okamoto
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] グルココルチコイドによる金属結合蛋白質metallothionein-4の誘導2017

    • Author(s)
      今村泰弘,十川千春,宮崎育子,浅沼幹人,十川紀夫
    • Organizer
      第131回日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Presentation] Metallothionein-4のグルココルチコイド応答領域2017

    • Author(s)
      今村泰弘,十川千春,荒 敏昭,十川紀夫
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] グルココルチコイドによるMT-IVの発現制御2017

    • Author(s)
      十川紀夫,十川千春,宮崎育子,浅沼幹人,今村泰弘
    • Organizer
      メタルバイオサイエンス研究会2017
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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