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Evaluation of implant capability from the aspect of cellular morphology regulation by surface topography and osteoimmunology

Research Project

Project/Area Number 17K11755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu University

Principal Investigator

OGINO YOICHIRO  九州大学, 歯学研究院, 准教授 (50380431)

Co-Investigator(Kenkyū-buntansha) 古谷野 潔  九州大学, 歯学研究院, 教授 (50195872)
鮎川 保則  九州大学, 歯学研究院, 准教授 (50304697)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsインプラント / ぬれ性 / 表面形状 / 細胞形態 / RhoA / RhoA / 歯学 / 歯科インプラント / 表面性状
Outline of Final Research Achievements

This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior.
Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.

Academic Significance and Societal Importance of the Research Achievements

口腔インプラントは、近年、歯の喪失した場合の治療法であるが、トラブルも多く報告されている。その背景には、インプラント体の過剰評価も一つの要因と考えている。そこで、本研究では、インプラント治療において有効でされているインプラントのぬれ性を細胞レベルで科学的に検証することにより、その能力を評価することとしている。
ぬれ性の高いインプラントは、これまでインプラントと骨の統合に有効とされてきたインプラント体の表面形状に加えてあくまでも補助的な効果であり、インプラントの成績を大きく変えることは過剰評価である可能性が考えられた。しかし、一定の有効性はあるために今後、その適応症例を検証する必要がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Influence of the wettability of different titanium surface topographies on initial cellular behavior2018

    • Author(s)
      Nishimura T, Ogino Y, Ayukawa Y, Koyano K.
    • Journal Title

      Dental Materials Journal

      Volume: 37 Issue: 4 Pages: 650-658

    • DOI

      10.4012/dmj.2017-334

    • NAID

      130007421346

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2018-07-26
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Cell Adhesion is Regulated by Titanium Surface Topographies and Wettability2018

    • Author(s)
      Nishimura T, Ogino Y, Ayukawa Y, Koyano K
    • Organizer
      96th General Session and Exhibition of The IADR
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] チタンの表面形状と表面特性の経時的変化が細胞反応に与える影響2017

    • Author(s)
      西村朋子、荻野洋一郎、鮎川保則、古谷野潔
    • Organizer
      公益社団法人日本補綴歯科学会第126回学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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