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Development of artificial enamel and dentin based on biomimetics for novel dental restoration system

Research Project

Project/Area Number 17K11761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu Dental College

Principal Investigator

Shimizu Hiroshi  九州歯科大学, 歯学部, 教授 (80162709)

Co-Investigator(Kenkyū-buntansha) 永松 有紀  九州歯科大学, 歯学部, 助教 (40220579)
池田 弘  九州歯科大学, 歯学部, 助教 (80621599)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords人工エナメル質 / 人工象牙質 / コンポジット / 歯科補綴学一般
Outline of Final Research Achievements

We have developed novel composite, artificial enamel, with its mechanical properties close to human enamel. The mechanical properties of the artificial enamel can be tailored by the preparation conditions. By modification of the artificial enamel, an artificial dentin can also be developed. Flexural strength of the artificial enamel could be improved by introducing the silane treatment. The artificial enamel can bond to a resin cement via silanization.

Academic Significance and Societal Importance of the Research Achievements

本研究により、ヒトの本来の歯に限りなく近い状況を再現できる世界初の理想的な歯冠修復システムを実現するための人工エナメル質が開発できた。新規人工エナメル質が実用化されれば、現在臨床で問題になっているCAD/CAM冠の脱離や破折が一挙に解決することが期待される。さらに、本研究で開発した人工エナメル質は安価な素材だけで作製できるので、価格の高騰が問題になっている金銀パラジウム合金の代替材料になりうる可能性も十分にもっているものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (20 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (17 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Correlation between microstructure of CAD/CAM composites and the silanization effect on adhesive bonding2020

    • Author(s)
      Yano Haruka Takesue、Ikeda Hiroshi、Nagamatsu Yuki、Masaki Chihiro、Hosokawa Ryuji、Shimizu Hiroshi
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 101 Pages: 103441-103441

    • DOI

      10.1016/j.jmbbm.2019.103441

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Data on changes in flexural strength and elastic modulus of dental CAD/CAM composites after deterioration tests2019

    • Author(s)
      Ikeda Hiroshi、Nagamatsu Yuki、Shimizu Hiroshi
    • Journal Title

      Data in Brief

      Volume: 24 Pages: 103889-103889

    • DOI

      10.1016/j.dib.2019.103889

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of silica?poly(methyl methacrylate) composite with a nanoscale dual-network structure and hardness comparable to human enamel2019

    • Author(s)
      Ikeda Hiroshi、Nagamatsu Yuki、Shimizu Hiroshi
    • Journal Title

      Dental Materials

      Volume: 35 Issue: 6 Pages: 893-899

    • DOI

      10.1016/j.dental.2019.03.006

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Preparation of SiO2;-PMMA composite with a nanoscale dual-network structure2019

    • Author(s)
      Ikeda Hiroshi, Nagamatsu Yuki, Shimizu Hiroshi
    • Organizer
      97th General Session & Exhibition of the IADR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of microstructure of CAD/CAM composite resin on adhesive bonding2019

    • Author(s)
      Yano Haruka, Ikeda Hiroshi, Nagamatsu Yuki, Masaki Chihiro, Hosokawa Ryuji, Shimizu Hiroshi
    • Organizer
      97th General Session & Exhibition of the IADR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation and Characterization of polymer-infiltrated-ceramic with hardness comparable to human-enamel2019

    • Author(s)
      Ikeda Hiroshi, Nagamatsu Yuki, Shimizu Hiroshi
    • Organizer
      4th meeting of the IADR Asia Pacific Region 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 孤立シラノール基の制御とナノ共連続構造体の曲げ強さ2019

    • Author(s)
      池田 弘,永松有紀,清水博史
    • Organizer
      第73回日本歯科理工学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Influence of silane treatment on bonding of CAD/CAM composite resins2019

    • Author(s)
      Yano H, Ikeda H, Nagamatsu Y, Masaki C, Hosokawa R, Shimizu H
    • Organizer
      7th Biennial Joint Congress of KAP-CPS-JPS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of silane treatment on adhesive bonding of CAD/CAM composite resin.2018

    • Author(s)
      Yano H, Ikeda H, Nagamatsu Y, Masaki C, Hosokawa R, Shimizu H
    • Organizer
      6th Asian Pacific International Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polymer infiltrated SiO2-PMMA composite with compatible hardness to enamel2018

    • Author(s)
      Ikeda H, Nagamatsu Y, Shimizu H
    • Organizer
      2018 IADR/PER Genetral Session & Exhibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] SiO2-PMMA ナノ共連続構造体の機械的性質2018

    • Author(s)
      池田 弘, 永松有紀, 清水博史
    • Organizer
      第71回日本歯科理工学会春期学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] CAD/CAM用コンポジットレジンの微細構造と接着におけるシランカップリング剤の効果2018

    • Author(s)
      矢野良佳, 池田 弘, 永松有紀, 正木千尋, 細川隆司, 清水博史
    • Organizer
      第78回九州歯科学会総会・学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] CAD/CAM 用コンポジットレジンの表面性状がシラン処理の効果に及ぼす影響2018

    • Author(s)
      矢野良佳, 池田 弘, 永松有紀, 正木千尋, 細川隆司, 清水博史
    • Organizer
      平成30年度日本歯科理工学会九州地方会夏期セミナー
    • Related Report
      2018 Research-status Report
  • [Presentation] CAD/CAM用コンポジットレジンの微細構造と表面性状がシラン処理に及ぼす影響2018

    • Author(s)
      矢野良佳, 池田 弘, 正木千尋, 細川隆司, 清水博史
    • Organizer
      平成30年度日本補綴歯科学会九州支部学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 池田 弘, 永松有紀, 清水博史2018

    • Author(s)
      有機-無機ナノ共連続構造体の作製工程へのシラン処理の導入とその効果
    • Organizer
      第72回日本歯科理工学会秋期学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] CAD/CAM用コンポジットレジンの表面自由エネルギーがシラン処理の効果に及ぼす影響2018

    • Author(s)
      矢野良佳, 池田 弘, 永松有紀, 正木千尋, 細川隆司, 清水博史
    • Organizer
      第37回日本接着歯学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規な共連続ナノ構造をもつ複合材料の開発2017

    • Author(s)
      池田 弘,永松有紀,清水博史
    • Organizer
      日本歯科理工学会九州地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒトエナメル質と同等の硬さを持つCAD/CAM用新素材の開発2017

    • Author(s)
      池田 弘,永松有紀,清水博史
    • Organizer
      日本補綴歯科学会九州支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒトエナメル質と同等の硬さを持つ歯冠修復複合材料の開発2017

    • Author(s)
      池田 弘,永松有紀,清水博史
    • Organizer
      第70回日本歯科理工学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高接着性を目指した新規歯冠修復用複合材料の開発2017

    • Author(s)
      池田 弘,永松有紀,川口智弘,髙橋 裕,清水博史
    • Organizer
      第36回日本接着歯学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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