Tongue position controlling in the treatment of obstructive sleep apnea
| Project/Area Number |
17K11793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
FUKUDA Tatsuya 公益財団法人神経研究所, 研究部, 研究員 (90624833)
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| Co-Investigator(Kenkyū-buntansha) |
對木 悟 公益財団法人神経研究所, 研究部, 研究員 (90376765)
依田 哲也 埼玉医科大学, 医学部, 客員教授 (60242210)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 閉塞性睡眠時無呼吸 / 口腔内装置 / 舌位置保持 / 陰圧負荷 / 舌 / 閉塞性睡眠時無呼吸症候群 |
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| Outline of Final Research Achievements |
Alternative approaches to nasal continuous positive airway pressure and/or mandibular advancement devices have been appealing in the treatment of obstructive sleep apnea (OSA) for decades. In our exploratory studies, we succeeded in demonstrating that the maintenance of awake tongue position during sleep is one possible concept for the development of an alternative therapy for OSA. The newly developed device (tongue position retainer: TPR) represents an OSA therapy without the use of positive airway pressure and mandibular advancement. It does not need power supply to generate the negative pressure to hold the tongue. A randomized-controlled crossover trial to investigate the efficacy of TPR is being planned in our next study. The TPR is currently patent pending.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で開発した治療法は、睡眠時に舌を吸引保持することにより上気道を確保する治療法であり、陽圧や下顎前方移動を治療手段に用いない点を特徴としている。つまり、持続陽圧呼吸（CPAP)や下顎前方移動型口腔内装置（MAD）など既存の治療法の副作用を回避でき、CPAPやMADを用いることのできない患者に対しても対応可能である。また、吸引のための電源を必要としないことも大きな特徴である。
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Report
(4 results)
Research Products
(14 results)
