Development of new peri-implant bone regeneration therapy using osseointegration related factors

Research Project

Project/Area Number	17K11794
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Hokkaido University
Principal Investigator	Horiuchi Rumi 北海道大学, 大学病院, 助教 (10374274)
Co-Investigator(Kenkyū-buntansha)	横山敦郎北海道大学, 歯学研究院, 教授 (20210627) 堀内正隆北海道医療大学, 薬学部, 准教授 (90322825)
Project Period (FY)	2017-04-01 – 2021-03-31
Project Status	Completed (Fiscal Year 2020)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	オッセオインテグレーション / インプラント周囲炎 / チタン / 歯科 / 生体材料 / 遺伝子 / 蛋白質
Outline of Final Research Achievements	It is an important issue in implant clinical practice to re-acquisition osseointegration lost due to the progression of peri-implantitis and to regenerate the surrounding bone. We have identified several genes that fluctuate due to micro-agitation in the early stages of implant placement. In this study, the effects of translation products of each of these variable genes on bone formation were verified in vitro. As a result, it was suggested that the addition of Dmp1, which is significantly expressed in the osseointegration acquired group, affects the osseointegration.
Academic Significance and Societal Importance of the Research Achievements	本研究の成果に基づいて開発される医薬品は、学術的なエビデンスに基づいており、安全でより確実な次世代のインプラント治療へと発展的につながることが期待される。インプラント周囲炎の重症化で骨結合を喪失し、現在ならばインプラント体の除去を検討しなければならないような臨床的に厳しい状況においても、オッセオインテグレーションを再び獲得できるようになることが予想される。