| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The maxillofacial boney and soft-tissue defects following oral and maxillofacial tumor and trauma can cause loss of oral function and esthetics. They need oral and maxillofacial reconstructive surgery by using a tissue engineering and bioregenerative treatment approach. With this scientific grant, I tried to develop an innovative maxillofacial boney regenerative treatment using super-selectively derived dental pulp stem cells and bioactive/bioresorbable 3D-porous-uHA-poly-DL-lactide composite scaffold (3D-uHA/PDLLA). I applied these human super-selectively derived dental pulp stem cells into 3D-uHA/PDLLA scaffold and grafted them into rat mandibular critical bone defect models. The results obtained revealed that the grafted models tended to show more boney regeneration in rats' mandibular defects, but not statisticaly significant compared with control groups. The further research remains needed to identify feasible grafting conditions and to develop feasible bone graft scaffolds.
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