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Multiscale analysis of peri-implant bone based on mechanobiology

Research Project

Project/Area Number 17K11808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Yajima Yasutomo  東京歯科大学, 歯学部, 教授 (10183667)

Co-Investigator(Kenkyū-buntansha) 山口 朗  東京歯科大学, 歯学部, 客員教授 (00142430)
守 源太郎  東京歯科大学, 歯学部, 助教 (30733745)
松永 智  東京歯科大学, 歯学部, 准教授 (70453751)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsインプラント / メカノバイオロジー / 顎骨 / 荷重伝達経路 / 応力 / 骨質 / 結晶配向性 / 機械的負荷 / アパタイト結晶配向性 / インプラント周囲顎骨 / マルチスケール解析
Outline of Final Research Achievements

For obtaining and maintaining osseointegration, characterizing the bone around the implant is important. However, the structural and biological properties of peri-implant bone remain unclear. Therefore, we designed this study for conducting a human jawbone sample analysis, establishing an animal model, promoting the structural analysis of the peri-implant bone, and clarifying the following points.(1): It was revealed that the newly formed peri-implant bone has a cortical bone-like structure and is biomechanically optimized to buffer the load applied through the implant.(2): Moreover, the amount of new bone was found to have increased around the implant where normal mechanical stress was applied without tail suspension.

Academic Significance and Societal Importance of the Research Achievements

オッセオインテグレーションの獲得と維持には、インプラント周囲骨の特徴を明らかにすることが重要である。本研究の推進により、インプラント周囲骨の骨質とコラーゲンの走行を中心とした構造的特徴の一端を明らかにすることができた。さらに本研究の成果は、顎骨の支持能力を生体力学的見地に基づいた顎骨診断を実現し、歯科医師による顎骨のミクロ・ナノレベル制御を可能にするものと期待され、学術的価値のみならず将来の骨疾患治療法の確立にも意義のある研究と考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 5 results) Presentation (18 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur2020

    • Author(s)
      NAKAJIMA Kosuke、MATSUNAGA Satoru、MORIOKA Toshiyuki、NAKANO Takayoshi、ABE Shinichi、FURUYA Yoshitaka、YAJIMA Yasutomo
    • Journal Title

      Dental Materials Journal

      Volume: 39 Issue: 4 Pages: 670-677

    • DOI

      10.4012/dmj.2019-187

    • NAID

      130007884178

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2020-07-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-temperature degradation of high-strength Y-TZP (yttria-stabilized tetragonal zirconia polycrystal)2020

    • Author(s)
      FURUYA Katsunori、TAKEMOTO Shinji、YAMASHITA Shuichiro、SEKINE Hideshi、YAJIMA Yasutomo、YOSHINARI Masao
    • Journal Title

      Dental Materials Journal

      Volume: 39 Issue: 4 Pages: 577-586

    • DOI

      10.4012/dmj.2019-090

    • NAID

      130007884192

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2020-07-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses2020

    • Author(s)
      Kasahara Masaaki、Matsunaga Satoru、Someya Tomoko、Kitamura Kei、Odaka Kento、Ishimoto Takuya、Nakano Takayoshi、Abe Shinichi、Hattori Masayuki
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: in press Issue: 7 Pages: 00-00

    • DOI

      10.1002/jbm.b.34609

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on Compressive Property of Aluminum Alloy Lattice Structure Additively Manufactured by 3D Printing Technology2019

    • Author(s)
      TAKANO Naoki、TAKIZAWA Hideo、ITO Kohta、ODAKA Kento、MATSUNAGA Satoru、ABE Shinichi
    • Journal Title

      Journal of the Society of Materials Science, Japan

      Volume: 68 Issue: 4 Pages: 351-357

    • DOI

      10.2472/jsms.68.351

    • NAID

      130007635145

    • ISSN
      0514-5163, 1880-7488
    • Year and Date
      2019-04-15
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Applying intraoral scanner to residual ridge in edentulous regions: in vitro evaluation of inter-operator validity to confirm trueness2019

    • Author(s)
      Tasaka Akinori、Uekubo Yuuki、Mitsui Tomoharu、Kasahara Takao、Takanashi Takuya、Homma Shinya、Matsunaga Satoru、Abe Shinichi、Yoshinari Masao、Yajima Yasutomo、Sakurai Kaoru、Yamashita Shuichiro
    • Journal Title

      BMC Oral Health

      Volume: 19 Issue: 1 Pages: 264-264

    • DOI

      10.1186/s12903-019-0918-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The characteristic regulation of gene expression Lbp and Sod3 in peri‐implant connective tissue of rats2019

    • Author(s)
      Kobayashi Takafumi、Sasaki Hodaka、Asami Yosuke、Mori Gentaro、Yoshinari Masao、Yajima Yasutomo
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 108 Issue: 3 Pages: 592-600

    • DOI

      10.1002/jbm.a.36839

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Full‐Arch Implant‐Supported Fixed Dental Prosthesis Retained by a Combination of Galvano‐Telescopic Copings and Screws: A Clinical Report2019

    • Author(s)
      Mori Gentaro、Iwai Kazuya、Oda Yukari、Furuya Yoshitaka、Yajima Yasutomo
    • Journal Title

      Journal of Prosthodontics

      Volume: 28 Issue: 9 Pages: 947-950

    • DOI

      10.1111/jopr.13117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of full‐arch screw‐retained implant‐supported fixed prostheses and full‐arch telescopic‐retained implant‐supported fixed prostheses: A 5-12 year follow‐up retrospective study2019

    • Author(s)
      Mori Gentaro、Oda Yukari、Sakamoto Kei、Ito Taichi、Yajima Yasutomo
    • Journal Title

      Clinical Oral Implants Research

      Volume: 30 Issue: 3 Pages: 197-205

    • DOI

      10.1111/clr.13406

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro- and Nanostructural Characteristics of Rat Masseter Muscle Entheses2019

    • Author(s)
      Arakawa Keitaro、Matsunaga Satoru、Nojima Kunihiko、Nakano Takayoshi、Abe Shinichi、Yoshinari Masao、Sueishi Kenji
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 28 Issue: 4 Pages: 365-370

    • DOI

      10.2485/jhtb.28.365

    • NAID

      130007738999

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients2019

    • Author(s)
      Mitomo Keisuke、Matsunaga Satoru、Kitamura Kei、Nakamura Takashi、Saito Akiko、Komori Toshihisa、Muramatsu Takashi、Yamaguchi Akira
    • Journal Title

      Bone

      Volume: 120 Pages: 176-186

    • DOI

      10.1016/j.bone.2018.10.028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on bone quality in the human mandible-Alignment of biological apatite crystallites2018

    • Author(s)
      Furukawa Takehiro、Matsunaga Satoru、Morioka Toshiyuki、Nakano Takayoshi、Abe Shinichi、Yoshinari Masao、Yajima Yasutomo
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 107 Issue: 3 Pages: 838-846

    • DOI

      10.1002/jbm.b.34180

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel condylar repositioning method for 3D-printed models2018

    • Author(s)
      Sugahara K, Katsumi Y, Koyachi M, Koyama Y, Matsunaga S, Odaka K, Abe S, Takano M, Katakura A.
    • Journal Title

      Maxillofac Plast Reconstr Surg.

      Volume: 40 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s40902-018-0143-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological Study on the Fibula in Japanese: Basic Anatomical Study for Maxillofacial Reconstruction2018

    • Author(s)
      Hirouchi Hidetomo、Shimoo Yoshiaki、Suzuki Masashi、Matsunaga Satoru、Yamamoto Masahito、Odaka Kento、Kitamura Kei、Koresawa Kazuto、Yanagisawa Nobuaki、Sakiyama Koji、Takayama Takeshi、Hayashi Katsuhiko、Chang Wei-Jen、Abe Shinichi
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 27 Issue: 4 Pages: 287-294

    • DOI

      10.2485/jhtb.27.287

    • NAID

      40021727255

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 日本人腓骨は顎顔面再建手術後の歯科インプラント埋入に十分な骨量/骨質を有するのか?2019

    • Author(s)
      小川雄大,廣内英智,野口 拓,山本将仁,松永智,阿部伸一
    • Organizer
      第49回日本口腔インプラント学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯科インプラント周囲に新生された顎骨のミクロ/ナノ構造特性2019

    • Author(s)
      松永 智,是澤和人,奥寺元,鈴木正史,吉成正雄,矢島安朝,阿部伸一
    • Organizer
      第49回日本口腔インプラント学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス大腿骨の生体アパタイト結晶配向性が尾部懸垂により生じる変化について2019

    • Author(s)
      中島孝輔,松永智,古川丈博,阿部伸一,古谷義隆,矢島安朝
    • Organizer
      第49回日本口腔インプラント学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 尾部懸垂マウス大腿骨へ埋入したインプラントの周囲骨への影響2019

    • Author(s)
      大津雄人,松永 智,中島孝輔,古川丈博,矢島安朝
    • Organizer
      第49回日本口腔インプラント学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 顎顔面再建手術後の歯科インプラント埋入を想定した日本人腓骨の形態学的基礎研究2019

    • Author(s)
      廣内英智,小川雄大,橋本千明,髙木貴博,山本悠太郎,松永 智,阿部伸一
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 尾部懸垂マウス大腿骨へ埋入したインプラント周囲骨への影響2019

    • Author(s)
      大津 雄人 松永 智 中島 孝輔 古川 丈博 阿部 伸一 矢島 安朝
    • Organizer
      第23回日本顎顔面インプラント学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of Tail Suspension on Apatite Crystallites of Mouse Femur2018

    • Author(s)
      K. Nakajima, S. Matsunaga, M. Iwata, T. Morioka, M. Yoshinari, Y. Yajima
    • Organizer
      The 96 th GENERAL SESSION & EXHIBITION OF THE IADR
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト無歯下顎骨前歯部皮質骨における生体アパタイト結晶配向性2018

    • Author(s)
      古川丈博, 松永智, 中島孝輔, 森岡俊行, 中野貴由, 阿部伸一, 吉成正雄, 矢島安朝
    • Organizer
      第48回日本口腔インプラント学会・学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] インプラント周囲骨における骨質特性の分析2018

    • Author(s)
      小髙研人,是澤和人,松永 智,阿部伸一
    • Organizer
      第305回東京歯科大学学会例会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯科インプラント周囲に新生された顎骨のミクロ/ナノ構造特性2018

    • Author(s)
      松永 智,是澤和人,奥寺 元,鈴木正史,吉成正雄,矢島 安朝,阿部 伸一
    • Organizer
      第48回公益社団法人 日本口腔インプラント学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 顎顔面再建手術後の歯科インプラント埋入を想定した日本人腓骨の解剖学的研究2018

    • Author(s)
      小川 雄大,廣内 英智,山本 将仁,松永 智,阿部伸一
    • Organizer
      第48回公益社団法人 日本口腔インプラント学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新生児および成獣におけるカピバラの骨構造特性2018

    • Author(s)
      松永 智,笠原典夫,北村 啓,阿部伸一
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体アパタイト結晶配向性が尾部懸垂による負荷減少時に受ける影響について2018

    • Author(s)
      中島孝輔,松永智,古川丈博,岩田優行,森岡俊之,吉成正雄,矢島安朝
    • Organizer
      第37回関東・甲信越支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト無歯下顎骨前歯部皮質骨における生体アパタイト結晶配向性2017

    • Author(s)
      古川丈博, 松永智, 岩田優行, 森岡俊行, 吉成正雄, 阿部伸一, 中野貴由, 矢島安朝
    • Organizer
      第37回日本骨形態計測学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Alignment of BAp crystallites in cortical bone of human mandible2017

    • Author(s)
      T. Furukawa, S. Matsunaga, M. Iwata, T. Morioka, M. Yoshinari, Y. Yajima
    • Organizer
      The 95th General Session & Exhibition of the International Association for Dental Research(IADR)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 尾部懸垂による負荷減少がマウス大腿骨の生体アパタイト(BAp)結晶配向性に与える影響2017

    • Author(s)
      1. 中島孝輔,松永智,古川丈博,岩田優行,森岡俊之,吉成正雄,矢島安朝
    • Organizer
      第47回日本口腔インプラント学会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尾部懸垂による負荷減少がマウス大腿骨の生体アパタイト(BAp)結晶配向性に与える影響2017

    • Author(s)
      中島孝輔,松永智,古川丈博,岩田優行,森岡俊之,吉成正雄,矢島安朝
    • Organizer
      第304回東京歯科大学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尾部懸垂による負荷減少がマウス大腿骨の生体アパタイト結晶配向性に与える影響2017

    • Author(s)
      中島孝輔,松永智,古川丈博,岩田優行,森岡俊之,矢島安朝
    • Organizer
      第21回日本顎顔面インプラント学会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Book] 口腔外科 YEARBOOK 一般臨床家、口腔外科医のための口腔外科ハンドマニュアル’192019

    • Author(s)
      日本口腔外科学会、古郷幹彦、栗田賢一、鄭 漢忠、桐田忠昭、瀬戸晥一、野間弘康
    • Total Pages
      252
    • Publisher
      クインテッセンス出版
    • ISBN
      9784781206912
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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