| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Titanium specimens were immobilized to statin drug to promote bone formation, and its sustained release and biocompatibility were examined. As a result, the number of hydroxyl groups on titanium specimens could be increased by NaOH treatment, and fluvastatin bound to gelatin via dopamine could be immobilized. Fluvastatin was found to be released in the collagen degrading enzyme solution during 24 hs. When gelatin/fluvastatin complex immobilized titanium disc was implanted into the subcutaneous tissue of the back of the rat, lymphocyte infiltration was observed 1 week after the implantation but no severe inflammation was confirmed.
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