Development of statin-released implant due to improvement of bone quality
| Project/Area Number |
17K11809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | インプラント / スタチン固定 / 薬剤徐放 / 表面分析 / 皮下組織反応 / インプラント周囲炎 / 薬剤固定 / チタン表面処理 / 骨形成 / チタン / 表面処理 / チタン合金 / スタチン / 徐放 / ゼラチン / ドラッグデリバリーシステム / 歯科材料 |
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| Outline of Final Research Achievements |
Titanium specimens were immobilized to statin drug to promote bone formation, and its sustained release and biocompatibility were examined. As a result, the number of hydroxyl groups on titanium specimens could be increased by NaOH treatment, and fluvastatin bound to gelatin via dopamine could be immobilized. Fluvastatin was found to be released in the collagen degrading enzyme solution during 24 hs. When gelatin/fluvastatin complex immobilized titanium disc was implanted into the subcutaneous tissue of the back of the rat, lymphocyte infiltration was observed 1 week after the implantation but no severe inflammation was confirmed.
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| Academic Significance and Societal Importance of the Research Achievements |
歯科用インプラントを埋入する際、母床骨が不足していると咬合力に耐えることができない。本研究では、母床骨の改善をインプラント材からアプローチするための画期的な方法であると言える。一方で、固定化したフルバスタチンの徐放を制御することを試み、生理食塩水中では徐放がみられなかったため、インプラント周囲炎のような炎症が生じ、上皮組織が侵入してくる際にスタチンを徐放し、骨形成を促す可能性があることが示唆された。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Loading of fluvastatin onto gelatin-coated titanium implants2018
Author(s)
S. Takemoto, K. Sasaki, S. Sugawara, S. Saitoh, T. Sawada, M. Taira, K. Tanabe, M. Yoshinari, M. Hattori, J. A. Jansen, S.G.G. Leeuwenburgh
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Journal Title
Key Engineering Materials
Volume: 782
Pages: 233-237
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Loading of Fluvastatin onto Gelatin-Coated Titanium Implants.2018
Author(s)
Shinji Takemoto, Kaori Sasaki, Shiho Sugawara, Setsuo Saitoh, Tomofumi Sawada, Masayuki Taira, Koji Tanabe, Masao Yoshinari, Masayuki Hattori, John A. Jansen, Sander G.G. Leeuwenburgh.
Organizer
30th Synmposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 30)
Related Report
