| Project/Area Number |
17K11846
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中村 誠司 九州大学, 歯学研究院, 教授 (60189040)
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | カテプシンK / pDC / mDC / 自己免疫性炎症 / Th17 / TLR9 / 口腔扁平苔癬 / サイトカイン / ヘルパーT細胞 / 樹状細胞 / ＴＳＬＰ / リンパ球 |
|---|
| Outline of Final Research Achievements |
For the purpose of identifying epithelial-derived disease-related molecules involved in the pathogenesis of oral lichen plan (OLP), pathological sections of patients were comprehensively analyzed by DNA microarray. As a result, cathepsin K (CTSK) was extracted as a humoral factor involved in the activation of Th (helper T) cells. CTSK was strongly expressed in the epithelium of the lesion and the infiltration of inflammatory cells immediately below it. Dendritic cells were extracted from human peripheral blood and stimulated with CTSK. As a result, it was suggested that dendritic cells such as mDC and pDC play an important role in the activation of Th subset of OLP.
|
| Academic Significance and Societal Importance of the Research Achievements |
WHOはOLPをpremalignant conditionからpotentially malignant disorderと位置づけたが、実際一部のOLP症例では扁平上皮癌への悪性転化が認められるため、OLPの病態進展をいかに抑制するかが治療上重要と考えられた。今回の研究によってカテプシンKがIL-6やIL-23などの炎症性サイトカイン産生を制御することが示唆され、Th17細胞分化を誘導することで自己免疫性炎症を引き起こすことが示唆された。これらの細胞に関与するDCサブセットをさらに明らかにすることで疾患の発症や重症化のメカニズム解明および新規治療薬の開発が期待される。
|
