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Involvement and function elucidation of stromal cells in the process of bone invasion of odontogenic tumors

Research Project

Project/Area Number 17K11865
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOkayama University of Science

Principal Investigator

Tsujigiwa Hidetsugu  岡山理科大学, 理学部, 教授 (70335628)

Co-Investigator(Kenkyū-buntansha) 山近 英樹  岡山大学, 大学病院, 講師 (10294422)
長塚 仁  岡山大学, 医歯薬学総合研究科, 教授 (70237535)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯原性腫瘍 / 骨浸潤 / 腫瘍間質相互作用 / エクソソーム / 微小環境
Outline of Final Research Achievements

Various studies have been conducted on ameloblastoma, however the details of their bone invasion mechanism remain unclear. In this study, we investigated the effects of tumor-stromal interactions in bone invasion of ameloblastoma. In ameloblastoma, tumor cells were thought to produce factors that suppress osteoblast differentiation. And also in ameloblastoma, it was considered that the stromal fibroblasts derived from tumor tissue was activated by tumor cells and promote to product MMPs , thus the stromal fibroblasts acquire the invasion bone ability. These results suggested that in ameloblastoma, bone invasion may be promoted by tumor-specific tumor-stromal interaction.

Academic Significance and Societal Importance of the Research Achievements

本研究により、エナメル上皮腫では腫瘍特異的な腫瘍間質細胞の相互作用により、骨芽細胞の分化抑制が生じ、骨組織の新生を阻害するとともに、間質線維芽細胞が腫瘍周囲組織に作用することで腫瘍細胞の浸潤を促進させている可能性が考えられた。
これらの研究成果は、エナメル上皮腫および、扁平上皮癌等エナメル上皮腫以外の腫瘍浸潤メカニズム解明に貢献すると考えられる。また、今後エナメル上皮腫の新規治療法開発に向けた基礎研究の発展に寄与することが考えられる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results)

  • [Journal Article] Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma2020

    • Author(s)
      Takabatake Kiyofumi、Kawai Hotaka、Omori Haruka、Qiusheng Shan、Oo May Wathone、Sukegawa Shintaro、Nakano Keisuke、Tsujigiwa Hidetsugu、Nagatsuka Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 20 Pages: 7714-7714

    • DOI

      10.3390/ijms21207714

    • NAID

      120006900773

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma2019

    • Author(s)
      Takabatake K, Shimo T, Murakami J, Anqi C, Kawai H, Yoshida S, Wathone Oo M, Haruka O, Sukegawa S, Tsujigiwa H, Nakano K, Nagatsuka H.
    • Journal Title

      Int J Mol Sci

      Volume: 20(22) Issue: 22 Pages: 5779-5779

    • DOI

      10.3390/ijms20225779

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differentiation and roles of bone marrow-derived cells on the tumor microenvironment of oral squamous cell carcinoma2019

    • Author(s)
      Anqi C, Takabatake K, Kawai H, Oo MW, Yoshida S, Fujii M, Omori H, Sukegawa S, Nakano K, Tsujigiwa H, Jinhua Z, Nagatsuka H.
    • Journal Title

      Oncol Lett

      Volume: 18(6) Pages: 6628-6638

    • DOI

      10.3892/ol.2019.11045

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] エナメル上皮腫および間質との相互作用が骨組織におよぼす影響について2018

    • Author(s)
      澄 文香、阪上峻基、浜田芽衣、高畠清文、長塚 仁、辻極秀次
    • Organizer
      第27回硬組織再生生物学会学術大会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] エナメル上皮腫および腫瘍間質線維芽細胞におよぼす影響について2018

    • Author(s)
      阪上 峻基、澄 文香、浜田 芽衣、長塚 仁、辻極 秀次
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] エナメル上皮腫細胞と骨芽細胞の細胞間相互作用解析2017

    • Author(s)
      澄 文香, 阪上峻基, 浜田芽衣, 長塚 仁, 辻極秀次
    • Organizer
      日本組織培養学会 第90回大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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