Identification of genetic and epigenetic abnormalities in oral mucosa

• Project/Area Number: 17K11868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Abe Masanobu 東京大学, 保健・健康推進本部, 講師 (10392333)
• Co-Investigator(Kenkyū-buntansha): 小笠原 徹 東京大学, 医学部附属病院, 講師 (20359623) ; 安部 貴大 東京大学, 医学部附属病院, 講師 (20383250)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 口腔がん / エピジェネティクス / 口腔粘膜 / DNAメチル化

Outline of Final Research Achievements

Oral mucosa is affected various stimulation such as food, chemicals and so on. Thus, accumulation of genetic and epigenetic abnormalities is considered to be associated with occurrence of oral cancer. In this study, we tried to identify rare mutations and accumulation of DNA methylation.

Academic Significance and Societal Importance of the Research Achievements

最新の解析手法を用いて、がん化のリスクが高いと考えられる非がん口腔粘膜において、ジェネティックおよびエピジェネティック異常の同定を試みた。口腔がんの早期発見を可能にする異常の同定に成功すれば、口腔がんのリスクの高い人を見極めることが可能となり、がんの予防や早期発見に大きく貢献することが予測される。

Research Products

• [Journal Article] A difficult-to-diagnose case of extranodal NK/T-cell lymphoma, nasal type, primary to maxillary gingival ulcers that developed after living-donor liver transplantation. (2020)
  • Author(s): Kawakami M, Yonenaga K, Suenaga H, Abe M, Takato T, Hoshi K.
  • Journal Title: Oral Science International Volume: 17(2) Issue: 2 Pages: 97-102
  • DOI: 10.1002/osi2.1040
  • Peer Reviewed
• [Journal Article] A rare case of myoepithelial carcinoma gradually changing into malignancy: A report and literature review. (2019)
  • Author(s): Kurabayashi K, Abe T., Abe M, Ikemura M, Takato T, Hoshi K.
  • Journal Title: Oral Science International Volume: 16(2) Issue: 2 Pages: 100-105
  • DOI: 10.1002/osi2.1004
  • Peer Reviewed / Open Access
• [Journal Article] A bilocular radicular cyst with tooth structure components inside. (2019)
  • Author(s): Noda A, Abe M , Ushiku A, Ohata Y, Zong L, Abe T, Hoshi K.
  • Journal Title: Case Reports in Dentistry Volume: 6245808 Pages: 1-4
  • DOI: 10.1155/2019/6245808
  • Peer Reviewed / Open Access
• [Journal Article] Replacement of temporomandibular head in a patient suffering from ankylosing spondylitis with severe ankylosis of the temporomandibular joints and whole spine. (2019)
  • Author(s): Yonenaga K, Hoshi K, Uchiyama T, Taniguchi A, Suenaga H, Abe M, Saijo H, Sakashita H, Takato T.
  • Journal Title: J Oral Maxillofac Surg Med Pathol Volume: 31 Issue: 1 Pages: 31-37
  • DOI: 10.1016/j.ajoms.2017.03.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: A rare case report and literature review (2019)
  • Author(s): Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashi S, Takai D, Ushijima T, Nagase T, Hoshi K
  • Journal Title: BMC Cancer Volume: 19(1) Issue: 1 Pages: 52-52
  • DOI: 10.1186/s12885-019-5277-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A comparative study of oral health status between international and Japanese university student patient in Japan. (2018)
  • Author(s): Osato M, Abe M, Ohkubo K, Zong L, Yoshimasu H, Hoshi K, Takato T, Yanagimoto S, Yamamoto K.
  • Journal Title: Healthcare Volume: 6(2)
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of CpG island methylator phenotype in gastric cancer. (2018)
  • Author(s): Xiao H, Fu J, Abe M, Ji J, Zong L.
  • Journal Title: Cancer Sci Volume: 109(8) Issue: 6 Pages: 2623-2625
  • DOI: 10.21147/j.issn.1000-9604.2017.06.14
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic subtypes of GISTs for stratifying patient response to sunitinib following imatinib-resistance: a pooled-analysis and systematic review. (2018)
  • Author(s): Tan S, Chen P, Ji J, Guo S, Yu D, Asakawa T, Zhou Y, Abe M, Zong L.
  • Journal Title: Dis Markers Volume: 2018:1368617 Pages: 1368617-1368617
  • DOI: 10.1155/2018/1368617
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BRAF inhibitor: a novel therapy for ameloblastomas in the mandible (2018)
  • Author(s): Abe M, Zong L, Abe T, Takeshima H, Ji J, Ushijima K, Hoshi K
  • Journal Title: Chinese Journal of Cancer Research Volume: 30(6) Issue: 6 Pages: 677-678
  • DOI: 10.21147/j.issn.1000-9604.2018.06.12
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A turning point in therapy for ameloblastomas. (2018)
  • Author(s): Abe M (Corresponding), Zong L, Abe T, Hoshi K.
  • Journal Title: Oral Oncology Volume: 80 Pages: 95-96
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ki67 is a Biological Marker of Malignant Risk of Gastrointestinal Stromal Tumors: A Systemic Review and Meta-analysis. (2017)
  • Author(s): Zhou Y, Hu W, Chen P, Abe M, Shi L, Song S, Tan S, Li Y, Zong L.
  • Journal Title: Medicine Volume: 96(34) Issue: 34 Pages: e7911-e7911
  • DOI: 10.1097/md.0000000000007911
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Feasibility of Laparoscopic Gastrectomy for Elderly Gastric Cancer Patients: Meta-analysis of Non-Randomised Controlled Studies. (2017)
  • Author(s): Zong L, Deng J, Wang J, Wu A, Wang J, Sun Z, Maeda M, Abe M, Wang W, Jiang Z, Seto Y and Ji J.
  • Journal Title: Oncotarget8(31):51878-51887 Volume: 8(31) Issue: 31 Pages: 51878-51887
  • DOI: 10.18632/oncotarget.16691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of systemic infection caused by Streptococcus pyogenes oral infection in an edentulous patient. (2017)
  • Author(s): Inagaki Y, Abe M, Inaki R, Zong L, Suenaga H, Abe T, Hoshi K.
  • Journal Title: Diseases Volume: 5（3） Issue: 3 Pages: 17-17
  • DOI: 10.3390/diseases5030017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In-hospital surgical treatment for haemorrhage after aesthetic mandibular osteotomy performed as an office-based day surgery: A case report. (2017)
  • Author(s): Kanke K, Abe T, Abe M, Mori Y, Hoshi K and Takato T.
  • Journal Title: Annals of Medicine and Surgery Volume: 24 Pages: 15-18
  • DOI: 10.1016/j.amsu.2017.10.001
  • Peer Reviewed / Open Access
• [Journal Article] Secretory Carcinoma - impact of translocation and gene fusions on salivary gland tumor - (2017)
  • Author(s): Inaki R, Abe M (Corresponding), Zong L, Abe T, Shinozaki-Ushiku A, Ushiku T and Hoshi K.
  • Journal Title: Chin J Cancer Res Volume: 29(5) Pages: 379-384
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Remarkably Different Results between Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic Syndromes. (2017)
  • Author(s): Wang G, Guo S, Xiao H, Zong L, Asakawa T, Abe M, Hu W, Ji J.
  • Journal Title: Chin J Cancer Res Volume: 29(6) Pages: 587-588
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Methylation-silencing in high-risk oral leukoplakia. (2019)
  • Author(s): Abe M, Yamashita S, Abe T, Ushijima T, Hoshi K.
  • Organizer: The 11th AACR-JCA Joint Conference on breakthroughs in Cancer Research: Biology to Precision Medicine
  • Int'l Joint Research
• [Presentation] The association between genetic and epigenetic abnormalities in oral squamous cell carcinomas. (2018)
  • Author(s): 阿部雅修、安部貴大、西條英人、星和人
  • Organizer: 第61回日本口腔外科学会総会・学術大会
• [Presentation] High-risk oral leukoplakia is associated with promoter methylation of multiple genes. (2018)
  • Author(s): Abe M, Abe T, Mori Y, Hoshi K.
  • Organizer: The 13th Asian Congress of Oral & Maxillofacial Surgery (ACOMS)
  • Int'l Joint Research