Identification of genetic and epigenetic abnormalities in oral mucosa
| Project/Area Number |
17K11868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Abe Masanobu 東京大学, 保健・健康推進本部, 講師 (10392333)
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| Co-Investigator(Kenkyū-buntansha) |
小笠原 徹 東京大学, 医学部附属病院, 講師 (20359623)
安部 貴大 東京大学, 医学部附属病院, 講師 (20383250)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔がん / エピジェネティクス / 口腔粘膜 / DNAメチル化 |
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| Outline of Final Research Achievements |
Oral mucosa is affected various stimulation such as food, chemicals and so on. Thus, accumulation of genetic and epigenetic abnormalities is considered to be associated with occurrence of oral cancer. In this study, we tried to identify rare mutations and accumulation of DNA methylation.
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| Academic Significance and Societal Importance of the Research Achievements |
最新の解析手法を用いて、がん化のリスクが高いと考えられる非がん口腔粘膜において、ジェネティックおよびエピジェネティック異常の同定を試みた。口腔がんの早期発見を可能にする異常の同定に成功すれば、口腔がんのリスクの高い人を見極めることが可能となり、がんの予防や早期発見に大きく貢献することが予測される。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: A rare case report and literature review2019
Author(s)
Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashi S, Takai D, Ushijima T, Nagase T, Hoshi K
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Journal Title
BMC Cancer
Volume: 19(1)
Issue: 1
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Feasibility of Laparoscopic Gastrectomy for Elderly Gastric Cancer Patients: Meta-analysis of Non-Randomised Controlled Studies.2017
Author(s)
Zong L, Deng J, Wang J, Wu A, Wang J, Sun Z, Maeda M, Abe M, Wang W, Jiang Z, Seto Y and Ji J.
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Journal Title
Oncotarget8(31):51878-51887
Volume: 8(31)
Issue: 31
Pages: 51878-51887
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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