Analysis of cancer promoting action of C5a-C5a receptor system and its application to targeted therapy in oral cancer
| Project/Area Number |
17K11879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OGI HIDENAO 熊本大学, 病院, 非常勤診療医師 (10315426)
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| Co-Investigator(Kenkyū-buntansha) |
今村 隆寿 熊本大学, 大学院生命科学研究部(医), 准教授 (20176499)
田中 拓也 熊本大学, 病院, 非常勤診療医師 (30631767)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | C5a-C5a受容体経路 / 舌癌 / 腺様嚢胞癌 / C5a受容体 / 口腔がん / 歯科学 / がん転移 / がん微小環境因子 / アナフィラトキシン |
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| Outline of Final Research Achievements |
Cancer cell C5a-receptor (C5aR) expression in one forth to third of tongue or adenoid cystic carcinoma cases indicated an association of the C5a-C5aR system with human oral cancers. C5a generated in the mouse skin site through the activation of the complement system triggered by the immune complexes enhanced invasion and tumor formation of C5aR-positive mouse cancer cells inoculated into the site and recruited myeloid-derived suppressor cells that suppress the anti-tumor immune responses. Inhibition of the cancer promoting effects of C5a by a C5aR antagonist suggested an availability of the therapy targeting the C5a-C5aR system.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔癌には手術以外に放射線、抗癌剤による治療が行われるが、これらの治療法は特異性が低く嚥下障害等の様々な合併症を起こし患者の日常生活に大きな支障をもたらす。今回の研究で解明した癌細胞のC5a受容体発現と内因性C5aによる癌促進はC5a-C5a受容体経路を標的とした新規の癌治療法の有効性を示す。抗C5a受容体抗体やC5a受容体拮抗剤はこの経路を特異的に遮断するので、侵襲や合併症の少ない治療法として期待される。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Enhancement of cancer invasion and growth via the C5a-C5a receptor system: Implications with cancer promotion by autoimmune diseases and association with cervical cancer invasion.2019
Author(s)
Yoneda M, Imamura R, Nitta H, Taniguchi K, Saito F, Kikuchi K, Ogi H, Tanaka T, Katabuchi H, Nakayama H, and Imamura T.
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Journal Title
Oncol. Lett.
Volume: 17
Pages: 913-920
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] アンギオポエチンライク４の発現は口腔扁平上皮癌の予後マーカーとなりうる2017
Author(s)
田中拓也, 尾木秀直, 吉田遼司, 廣末晃之, 福間大喜, 川原健太, 松岡裕一郎, 坂田純基, 有田英生, 中嶋光, 今村隆寿, 中山秀樹
Organizer
第76回日本癌学会学術総会
Related Report
