Role of secretory miRNA on the metastasis of oral cancer via CXCR4 system
Project/Area Number |
17K11886
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Ehime University (2019) Dokkyo Medical University (2017-2018) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
木内 誠 獨協医科大学, 医学部, 助教 (00759483)
川又 均 獨協医科大学, 医学部, 教授 (70224847)
栗林 伸行 愛媛大学, 医学系研究科, 助教 (80617332)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 口腔癌 / 転移 / exosome / CXCR4 / exosome miRNA / マイクロRNA / 口腔がん / 分泌型miRNA |
Outline of Final Research Achievements |
We identified the several secretory miRNAs, such as miR-4701-3p, miR-503-3p and miR-134, upregulated by SDF-1, and miR-4785, miR-378e and miR-362-5p, downregulated by SDF-1. We also demonstrated that AMD070, an orally bioactive CXCR4 specific inhibitor, inhibited the SDF-1 dependent anchorage-independent growth and migration of the oral cancer cells in vitro, and that significantly suppressed the lung metastasis of the cells in vivo.
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Academic Significance and Societal Importance of the Research Achievements |
口腔癌の予後不良因子は転移である。われわれは、口腔癌の転移にSDF-1/CXCR4システムが関与していることを報告してきたが、血清レベルで本システムの関与を検出できれば、将来的にはliquid biopsyによる転移診断や治療効果判定、さらには予後判定を実施できる可能性がある。本研究では、CXCR4シグナルの下流に存在する分泌型miRNAを同定することができたため、今後転移診断の早期診断に応用できる可能性がある。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells.2018
Author(s)
Uchida D, Kuribayashi N, Kinouchi M, Sawatani Y, Shimura M, Mori T, Hasegawa T, Miyamoto Y, Kawamata H.
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Journal Title
Oncol Rep
Volume: 40
Pages: 303-308
DOI
Related Report
Peer Reviewed
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