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Evaluation as a functional analysis and the treatment target of ANGPTL4 in oral cancer

Research Project

Project/Area Number 17K11912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKumamoto University

Principal Investigator

Takuya Tanaka  熊本大学, 病院, 非常勤診療医師 (30631767)

Co-Investigator(Kenkyū-buntansha) 尾木 秀直  熊本大学, 病院, 非常勤診療医師 (10315426)
今村 隆寿  熊本大学, 大学院生命科学研究部(医), 准教授 (20176499)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺転移 / ANGPTL4 / 口腔癌 / 遠隔転移 / 転移
Outline of Final Research Achievements

The work as fat metabolism and the angiogenesis factor is noted Angiopoietin-like protein 4 (ANGPTL4).The possibility that ANGPTL4 was involved in a process of the vascular endothelial cells passage of the cancer cell in the distant metastasis of the cancer was reported recently.We thought that ANGPTL4 influenced extension of oral squamous cell carcinoma.We examined cancer mobility of ANGPTL4 and invasive sthenia, proliferative sthenia, and the like and determined tumor promotion potentiative action.

Academic Significance and Societal Importance of the Research Achievements

ヒト口腔扁平上皮癌(臨床検体、培養細胞株)が高頻度にC5a/ANGPTL4を発現していることが示され、ヒト癌でのアナフィラトキシン C5a/ ANGPTL4系の存在と癌増殖、運動性、浸潤亢進、転移、さらに患者予後への関与が明らかになる。C5a発現とこの受容体に依存したANGPTL4による癌促進作用、およびこの作用に関与するサイトカイン等の産生が示される。C5a/ANGPTL4系への抗C5aR抗体の癌抑制効果が示され、これら抗体の癌治療薬としての有効性が提示される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2020 2017

All Journal Article (2 results) Presentation (1 results)

  • [Journal Article] Metastasisofmalignantpleuralmesotheliomatomaxillarygingiva:Acase reportandliteraturereview2020

    • Author(s)
      TaKuya Tanaka
    • Journal Title

      JournalofOralandMaxillofacialSurgery,Medicine,and Pathology

      Volume: 32 Issue: 2 Pages: 140-144

    • DOI

      10.1016/j.ajoms.2019.10.008

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A rare mandibular osteosarcoma case of Li-Franmeni syndrome with a germline p53R273H mutation2020

    • Author(s)
      Hidenao Ogi
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 32 Pages: 132-135

    • Related Report
      2019 Annual Research Report
  • [Presentation] Angiopoietin-like protein 4 (Angptl4) expression is a poor prognosis factor of OSCC.2017

    • Author(s)
      田中拓也
    • Organizer
      日本癌学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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