| Project/Area Number |
17K11958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中田 匡宣 鹿児島大学, 医歯学域歯学系, 教授 (90444497)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔レンサ球菌 / マスト細胞 / アレルギー / 細胞死 / 過酸化水素 |
|---|
| Outline of Final Research Achievements |
Mast cells play central roles in allergic reaction. In this study, we found that H2O2 produced by mitis group streptococci such as Streptococcus oralis reduced degranulation of mast cells stimulated with IgE-antigen complex. The reduction of the degranulation was related to the H2O2-induced cell death. Lysosomal dysfunction by H2O2 seemed to contribute to the unique cell death. Using mouse model of pollen allergy, we found that streptococcus-derived H2O2 reduced the sneezing of the sensitized mice challenged with cedar pollen. These results suggest that H2O2 produced by the oral mitis group streptococci is able to disrupt the host allergic reaction.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔ミティス群レンサ球菌が産生する低濃度の過酸化水素が宿主の免疫応答やアレルギー応答に影響を与える可能性が示された．口腔常在細菌の代謝産物にそのような作用があることは従来全く想定されておらず、常在細菌が宿主に与える影響を考え直す必要があるのではないかと思われる．
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