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Functional role of Transforming growth factor beta during enamel formation

Research Project

Project/Area Number 17K11975
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTsurumi University

Principal Investigator

ASADA YOSHINOBU  鶴見大学, 歯学部, 教授 (20184145)

Co-Investigator(Kenkyū-buntansha) 山越 康雄  鶴見大学, 歯学部, 教授 (20182470)
山本 竜司  鶴見大学, 歯学部, 講師 (20410053)
唐木田 丈夫  鶴見大学, 歯学部, 講師 (40367305)
小林 冴子  鶴見大学, 歯学部, 助教 (90804534)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsエナメル質 / 幼若エナメル質 / エナメルタンパク質 / 生理活性物質 / TGF-β / アメロゲニン / エナメルたんぱく質 / TGF-β1
Outline of Final Research Achievements

We focused on transforming growth factor beta (TGF-β), which is found in the process of enamel formation, to elucidate its role and function, and mainly investigated the protein dynamics of TGF-β1. We have elucidated the autocrine mechanism of TGF-β1 by ameloblasts and the complex formation of TGF-β1 with amelogenin fragments in the enamel matrix. We have also identified possible roles for TGF-β in the induction of apoptosis in ameloblasts, endocytosis of amelogenin, and induction of epithelial-mesenchymal transition. Furthermore, we found that the effects on these functions differ among TGF-β isoforms (β1, β2, and β3).

Academic Significance and Societal Importance of the Research Achievements

本研究により、正常なエナメル質形成のメカニズム解明に迫ることのみならず、Amel-TGF-β複合体を応用した新たな歯科再生医療技術の構築が十分に考えられ、学術的および社会的意義は高い。またTGF-βアイソフォーム間による影響を検証することで、形成不全や腫瘍化に至る異常なシグナルについて知る可能性を示唆する。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2021 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] TGF-β autocrine signaling at secretory-stage enamel.2018

    • Author(s)
      Kobayashi S, Yamakoshi Y, and Asada Y.
    • Journal Title

      J Oral Biosci.

      Volume: 60, (3) Issue: 3 Pages: 70-75

    • DOI

      10.1016/j.job.2018.05.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effects of TGF-β isoforms on ameloblasts2021

    • Author(s)
      Y. MIYAKAWA, Y. YAMAKOSHI and Y. ASADA
    • Organizer
      JADR Annual Meeting
    • Related Report
      2021 Annual Research Report
  • [Presentation] Potential Function of TGF-β Isoforms in Maturation-stage Ameloblasts2019

    • Author(s)
      KOBAYASHI, M. OKUBO, R. CHIBA, R. YAMAMOTO, Y. YAMAKOSHI3, and Y. ASADA
    • Organizer
      97th General Session of the IADR Vancouver, BC, Canada
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] TGFβ-アイソフォームによる成熟期エナメルタンパク遺伝子発現の制御2019

    • Author(s)
      宮川友里,唐木田丈夫,小林冴子,山越康雄,朝田芳信
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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