Maternal periodontal disease induce fetal failure and postnatal glucose intolerance
Project/Area Number |
17K11982
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Katagiri Sayaka 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60510352)
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Co-Investigator(Kenkyū-buntansha) |
高橋 宏和 佐賀大学, 医学部, 講師 (20607783)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 歯周病 / 妊娠 / 低体重児出産 / 糖尿病 |
Outline of Final Research Achievements |
Growing evidence indicates an association between periodontitis and delivery outcome; however, the mechanism is unclear. This study aimed to investigate the influence of Porphyromonas gingivalis (Pg) infection on delivery outcome. In the human study, lower anti‐P. gingivalis IgG‐1 amounts are related to threatened preterm birth, while higher anti‐P. gingivalis IgG and IgG‐4 are related with small for gestational age in threatened preterm birth. A bacteremia model mouse was created by intravenous injection of Pg to pregnant Slc: ICR mice. Pg infection during the third trimester caused low birth weight and inflammation in the placenta and umbilical cord.
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Academic Significance and Societal Importance of the Research Achievements |
早産・低体重児は新生児の疾病罹患率、死亡率を増加させる有害な病態である。また、胎児発育不全は出生後の予後が不良となることもあり、周産期死亡率や精神発達遅滞の発症率も高く、成人後も疾病罹患率が高いなど軽視できない病態である。 本研究はP. gingivalis感染が低出生体重児出産を引き起こすことヒトおよびマウスモデルで示した点が非常に興味深く、歯周病が早産・低体重児出産に影響を及ぼすメカニズム解明の一助となることが期待できる。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Author Correction: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism.2018
Author(s)
Komazaki R, Katagiri S, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
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Journal Title
Sci Rep.
Volume: 12;8(1)
Issue: 1
Pages: 4620-4620
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolis.2017
Author(s)
Katagiri S, Komazaki R, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
Organizer
The 103rd Annual Meeting of American Academy of Periodontology
Related Report
Int'l Joint Research