| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of the present study was to assess the novel mechanisms linking periodontitis and rheumatoid arthritis (RA) by profiling of serum levels of carbamylated peptide (CarP) and neutrophil extracellular traps (NETs) in the patients with RA and the age-, gender-, smoking status-, and periodontal condition-matched controls. The results indicated that the patients with RA showed significantly higher levels of CarP and NETs than the controls. The data also showed that the serum levels of CarP and NETs were significantly correlated positively with periodontitis severity and were significantly decreased after periodontal treatment in the patients with RA. These results suggest an interrelationship between periodontitis and RA through serum peptide carbamylation and NETs formation.
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