Analysis of Biological Response of Elderly to Post-Scaling Bacteremia and Establishment of Prophylaxis by Phototherapy

• Project/Area Number: 17K11984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Kanagawa Dental College (2018-2022); Niigata University (2017)
• Principal Investigator: Morozumi Toshiya 神奈川歯科大学, 歯学部, 准教授 (20444151)
• Co-Investigator(Kenkyū-buntansha): 高橋 直紀 新潟大学, 医歯学系, 准教授 (80722842) ; 小松 康高 新潟大学, 医歯学総合病院, 助教 (40422597) ; 保苅 崇大 新潟大学, 医歯学総合病院, 医員 (30827621) ; 宮沢 春菜 新潟大学, 医歯学総合病院, 特任助教 (50733721)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 生体応答 / ストレス / 生体侵襲 / スケーリング / エルビウムヤグレーザー / 生理指標 / ストレスマーカー / 炎症性サイトカイン / 光治療 / 高齢者 / 菌血症

Outline of Final Research Achievements

Nonsurgical periodontal treatment, including scaling and root planing (SRP), acts as a strong inflammatory stimulus and may affect biological responses and autonomic nervous system activity. In this study, we investigated the effects of subgingival scaling with an erbium YAG (Er: YAG) laser on physiological parameters and blood stress markers, in contrast to SRP with a conventional hand scaler. The results suggest that the use of the Er: YAG laser has a smaller stress load on patients.

Academic Significance and Societal Importance of the Research Achievements

観血的歯周治療の後には，菌血症によりエンドトキシンや炎症性サイトカインが全身に広がり，軽度の急性期反応を示す。また，侵襲下の生体では神経・内分泌系，免疫系，代謝系，循環器系を中心に種々の変動が見られる。これらはお互い独立したものではなく，神経・内分泌系を介して生体反応を抑制するフィードバック機構が作動し，生体の恒常性を維持している。本研究では各系統のストレスマーカーを網羅し，侵襲の種類や程度によるストレス応答の変化を解析した。本研究の結果は，歯周治療の直後に全身に起きている生体変化を多角的に解析した初めての研究であり，その学術的および社会的意義は極めて高い。

Research Products

• [Journal Article] Educational Effectiveness of Instruction Using Video Teaching Materials to Impart Initial Periodontal Therapy Techniques (2023)
  • Author(s): 杉原 俊太郎、両角 俊哉、渕田 慎也、清水 統太、井上 允、琢磨 遼、門田 大地、櫻井 孝、小牧 基浩
  • Journal Title: The Japanese Journal of Conservative Dentistry Volume: 66 Issue: 1 Pages: 26-34
  • DOI: 10.11471/shikahozon.66.26
  • ISSN: 0387-2343, 2188-0808
  • Year and Date: 2023-02-28
  • Peer Reviewed / Open Access
• [Journal Article] Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study (2023)
  • Author(s): Takuma Ryo、Morozumi Toshiya、Yamamoto Yuko、Kobayashi Takashi、Matsui Takaaki、Yoneda Masato、Kessoku Takaomi、Nogami Asako、Tamura Muneaki、Kamata Yohei、Sugihara Shuntaro、Nomura Yoshiaki、To Masahiro、Minabe Masato、Mitsudo Kenji、Nakajima Atsushi、Komaki Motohiro
  • Journal Title: Applied Sciences Volume: 13 Issue: 6 Pages: 3893-3893
  • DOI: 10.3390/app13063893
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Locally Delivered Minocycline on the Profile of Subgingival Bacterial Genera in Patients with Periodontitis: A Prospective Pilot Study (2022)
  • Author(s): Morozumi Toshiya、Nakayama Yohei、Shirakawa Satoshi、Imamura Kentaro、Nohno Kaname、Nagano Takatoshi、Miyazawa Haruna、Hokari Takahiro、Takuma Ryo、Sugihara Shuntaro、Gomi Kazuhiro、Saito Atsushi、Ogata Yorimasa、Komaki Motohiro
  • Journal Title: Biomolecules Volume: 12 Issue: 5 Pages: 719-719
  • DOI: 10.3390/biom12050719
  • Peer Reviewed / Open Access
• [Journal Article] A cross-sectional study assessing the relationship between non-alcoholic fatty liver disease and periodontal disease (2022)
  • Author(s): Sato Satsuki、Kamata Yohei、Kessoku Takaomi、Shimizu Tomoko、Kobayashi Takashi、Kurihashi Takeo、Takashiba Shogo、Hatanaka Kazu、Hamada Nobushiro、Kodama Toshiro、Higurashi Takuma、Taguri Masataka、Yoneda Masato、Usuda Haruki、Wada Koichiro、Nakajima Atsushi、Morozumi Toshiya、Minabe Masato
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 13621-13621
  • DOI: 10.1038/s41598-022-17917-2
  • Peer Reviewed / Open Access
• [Journal Article] Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial (2022)
  • Author(s): Kamata Yohei、Kessoku Takaomi、Shimizu Tomoko、Sato Satsuki、Kobayashi Takashi、Kurihashi Takeo、Morozumi Toshiya、Iwasaki Tomoyuki、Takashiba Shogo、Hatanaka Kazu、Hamada Nobushiro、Kodama Toshiro、Higurashi Takuma、Taguri Masataka、Yoneda Masato、Usuda Haruki、Wada Koichiro、Nakajima Atsushi、Minabe Masato
  • Journal Title: Clinical and Translational Gastroenterology Volume: 13 Issue: 11 Pages: e00520-e00520
  • DOI: 10.14309/ctg.0000000000000520
  • Peer Reviewed / Open Access
• [Journal Article] Effect of High Fat and Fructo-Oligosaccharide Consumption on Immunoglobulin A in Saliva and Salivary Glands in Rats (2021)
  • Author(s): Yamamoto Yuko、Morozumi Toshiya、Takahashi Toru、Saruta Juri、Sakaguchi Wakako、To Masahiro、Kubota Nobuhisa、Shimizu Tomoko、Kamata Yohei、Kawata Akira、Tsukinoki Keiichi
  • Journal Title: Nutrients Volume: 13 Issue: 4 Pages: 1252-1252
  • DOI: 10.3390/nu13041252
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination (2021)
  • Author(s): Nomura Y, Morozumi T*, Numabe Y, Ogata Y, Nakayama Y, Sugaya T, Nakamura T, Sato S, Takashiba S, Sekino S, Yoshinari N, Hanada N, Sugano N, Fukuda M, Minabe M, Umeda M, Tabeta K, Takahashi K, Noguchi K, Kobayashi H, Takai H, Nishimura F, Suzuki F, Kakuta E, Yoshimura A, Saito A, Nakagawa T
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 4 Pages: 723-723
  • DOI: 10.3390/jcm10040723
  • Peer Reviewed / Open Access
• [Journal Article] Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis (2021)
  • Author(s): Nomura Y, Morozumi T*, Saito A, Yoshimura A, Kakuta E, Suzuki F, Nishimura F, Takai H, Kobayashi H, Noguchi K, Takahashi K, Tabeta K, Umeda M, Minabe M, Fukuda M, Sugano N, Hanada N, Yoshinari N, Sekino S, Takashiba S, Sato S, Nakamura T, Sugaya T, Nakayama Y, Ogata Y, Numabe Y, Nakagawa T
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 6 Pages: 1165-1165
  • DOI: 10.3390/jcm10061165
  • Peer Reviewed / Open Access
• [Journal Article] Faster Short-Chain Fatty Acid Absorption from the Cecum Following Polydextrose Ingestion Increases the Salivary Immunoglobulin A Flow Rate in Rats (2020)
  • Author(s): Yamamoto Yuko、Morozumi Toshiya、Takahashi Toru、Saruta Juri、To Masahiro、Sakaguchi Wakako、Shimizu Tomoko、Kubota Nobuhisa、Tsukinoki Keiichi
  • Journal Title: Nutrients Volume: 12 Issue: 6 Pages: 1745-1745
  • DOI: 10.3390/nu12061745
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effect of omega-3 fatty acids on alveolar bone resorption and osteoclast differentiation (2020)
  • Author(s): Ozaki Yu、Morozumi Toshiya、Watanabe Kiyoko、Toyama Toshizo、Sasaki Haruka、Sato Takenori、Yamamoto Yuko、To Masahiro、Inaba Keitaro、Tsukinoki Keiichi、Hamada Nobushiro、Minabe Masato
  • Journal Title: Journal of Oral Science Volume: 62 Issue: 3 Pages: 298-302
  • DOI: 10.2334/josnusd.19-0267
  • NAID: 130007863825
  • ISSN: 1343-4934, 1880-4926
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Periodontal Disease on Diabetic Retinopathy in Type 2 Diabetic Patients: A Cross-Sectional Pilot Study (2020)
  • Author(s): Yamamoto Yuko、Morozumi Toshiya、Hirata Takahisa、Takahashi Toru、Fuchida Shinya、Toyoda Masami、Nakajima Shigeru、Minabe Masato
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 10 Pages: 3234-3234
  • DOI: 10.3390/jcm9103234
  • Peer Reviewed / Open Access
• [Journal Article] Optimal Examination Sites for Periodontal Disease Evaluation: Applying the Item Response Theory Graded Response Model (2020)
  • Author(s): Nomura Y, Morozumi T*, Fukuda M, Hanada N, Kakuta E, Kobayashi H, Minabe M, Nakamura T, Nakayama Y, Nishimura F, Noguchi K, Numabe Y, Ogata Y, Saito A, Sato S, Sekino S, Sugano N, Sugaya T, Suzuki F, Takahashi K, Takai H, Takashiba S, Umeda M, Yoshie H, Yoshimura A, Yoshinari N, Nakagawa T
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 11 Pages: 3754-3754
  • DOI: 10.3390/jcm9113754
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effect of omega-3 fatty acids on alveolar bone resorption and osteoclast differentiation (2020)
  • Author(s): Ozaki Y, Morozumi T*, Watanabe K, Toyama T, Sasaki H, Sato T, Yamamoto Y, To M, Inaba K, Tsukinoki K, Hamada N, Minabe M
  • Journal Title: Journal of Oral Science Volume: in press
  • NAID: 130007863825
  • Peer Reviewed
• [Journal Article] Effect of Ingesting Yogurt Fermented With Lactobacillus Delbrueckii Ssp. bulgaricus OLL1073R-1 on Influenza Virus-Bound Salivary IgA in Elderly Residents of Nursing Homes: A Randomized Controlled Trial (2019)
  • Author(s): Yamamoto Y, Saruta J, Takahashi T, To M, Shimizu T, Hayashi T, Morozumi T, Kubota N, Kamata Y, Makino S, Kano H, Hemmi J, Asami Y, Nagai T, Misawa K, Kato S, Tsukinoki K.
  • Journal Title: Acta Odontologica Scandinavica Volume: 77(7) Issue: 7 Pages: 517-524
  • DOI: 10.1080/00016357.2019.1609697
  • Peer Reviewed / Open Access
• [Journal Article] Biological responses following one‐stage full‐mouth scaling and root planing with and without azithromycin: Multicenter randomized trial (2019)
  • Author(s): Yashima Akihiro、Morozumi Toshiya、Yoshie Hiromasa、Hokari Takahiro、Izumi Yuichi、Akizuki Tatsuya、Mizutani Koji、Takamatsu Hideyuki、Minabe Masato、Miyauchi Satomi、Yoshino Toshiaki、Tanaka Maki、Tanaka Yoshie、Gomi Kazuhiro
  • Journal Title: Journal of Periodontal Research Volume: 54 Issue: 6 Pages: 709-719
  • DOI: 10.1111/jre.12680
  • Peer Reviewed / Open Access
• [Journal Article] Smoking and periodontal microorganisms (2019)
  • Author(s): Hanioka T, Morita M, Yamamoto T, Inagaki K, Wang P-L, Ito H, Morozumi T, Takeshita T, Suzuki N, Shigeishi H, Sugiyama M, Ohta K, Nagao T, Hanada N, Ojima M, Ogawa H
  • Journal Title: The Japanese Dental Science Review Volume: 55 Issue: 1 Pages: 88-94
  • DOI: 10.1016/j.jdsr.2019.03.002
  • NAID: 50014414225
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: A randomized controlled trial (2019)
  • Author(s): Yamamoto Y, Saruta J, Takahashi T, To M, Shimizu T, Hayashi T, Morozumi T, Kubota N, Kamata Y, Makino S, Kano H, Hemmi J, Asami Y, Nagai T, Misawa K, Kato S, Tsukinoki K
  • Journal Title: Acta Odontologica Scandinavica Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets: A pilot study (2018)
  • Author(s): Hokari T, Morozumi T, Komatsu Y, Shimizu T, Yoshino T, Tanaka M, Tanaka Y, Nohno K, Kubota T, Yoshie H
  • Journal Title: International Journal of Dentistry Volume: － Pages: 1-9
  • DOI: 10.1155/2018/1748584
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and cone-beam CT evaluation of combinational periodontal regenerative therapies using enamel matrix derivative and deproteinized bovine bone mineral with or without collagen membrane (2018)
  • Author(s): Nemoto Y, Kubota T, Nohno K, Nezu A, Morozumi T, Yoshie H
  • Journal Title: International Journal of Periodontics & Restorative Dentistry Volume: 印刷中 Issue: 3 Pages: 373-381
  • DOI: 10.11607/prd.3288
  • Peer Reviewed
• [Journal Article] Increased systemic levels of inflammatory mediators following one-stage full-mouth scaling and root planing (2018)
  • Author(s): Morozumi T, Yashima A, Gomi K, Ujiie Y, Izumi Y, Akizuki T, Mizutani K, Takamatsu H, Minabe M, Miyauchi S, Yoshino T, Tanaka M, Tanaka Y, Hokari T, Yoshie H
  • Journal Title: Journal of Periodontal Research Volume: 印刷中 Issue: 4 Pages: 536-544
  • DOI: 10.1111/jre.12543
  • Peer Reviewed
• [Journal Article] A comparable study of combinational regenerative therapies comprising enamel matrix derivative plus deproteinized bovine bone mineral with or without collagen membrane in periodontitis patients with intrabony defects (2018)
  • Author(s): Kubota T, Nemoto Y, Nohno K, Nezu A, Morozumi T, Yoshie H
  • Journal Title: Open Journal of Stomatology Volume: 8 Issue: 09 Pages: 277-286
  • DOI: 10.4236/ojst.2018.89026
  • Peer Reviewed / Open Access
• [Journal Article] Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. (2017)
  • Author(s): Kakuta E, Nomura Y, Morozumi T, et al.
  • Journal Title: BMC Oral Health. Volume: 17 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s12903-017-0337-x
  • Peer Reviewed / Open Access
• [Journal Article] Expression of neprilysin in periodontitis-affected gingival tissues. (2017)
  • Author(s): Nezu A, Kubota T, Maruyama S, Nagata M, Nohno K, Morizumi T, Yoshie H.
  • Journal Title: Arch Oral Biol. Volume: 79 Pages: 35-41
  • DOI: 10.1016/j.archoralbio.2017.03.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of Er:YAG Laser in Periodontal Therapy and Its Possibility for Novel Prophylactic Method against Transient Bacteremia (2017)
  • Author(s): 小松康高、両角俊哉、吉江弘正
  • Journal Title: Nippon Laser Igakkaishi Volume: 38 Issue: 2 Pages: 158-166
  • DOI: 10.2530/jslsm.jslsm-38_0024
  • NAID: 130006163797
  • ISSN: 0288-6200, 1881-1639
  • Peer Reviewed
• [Journal Article] Site-level progression of periodontal disease during a follow-up period (2017)
  • Author(s): Nomura Yoshiaki、Yoshimura Atsutoshi、Hara Yoshitaka、Nakamura Toshiaki、Noguchi Kazuyuki、Kakuta Erika、Hanada Nobuhiro、Takashiba Shogo、Amitani Yasuharu、Yoshie Hiromasa、他
  • Journal Title: PLOS ONE Volume: 12 Issue: 12 Pages: e0188670-e0188670
  • DOI: 10.1371/journal.pone.0188670
  • Peer Reviewed / Open Access
• [Presentation] 糖尿病モデルラットにおける顎下腺組織IgA濃度とplgR発現量の解析 (2022)
  • Author(s): 山本裕子，猿田樹理，坂口和歌子，窪田展久，東 雅啓，清水智子，両角俊哉，高橋 徹，高垣裕子，槻木恵一
  • Organizer: 第76回日本栄養・食糧学会大会
• [Presentation] 歯周基本治療手技における動画教材の有効性検討 (2022)
  • Author(s): 両角俊哉, 渕田慎也, 櫻井 孝
  • Organizer: 第41回日本歯科医学教育学会総会および学術大会
• [Presentation] 全身性疾患への影響を考慮した新たな歯周病重症度検査項目の策定～学会主導型多施設臨床研究～ (2022)
  • Author(s): 松田真司，菅谷 勉，加藤幸紀，根本英二，竹内康雄，喜田大智，沼部幸博，西田哲也， 小方賴昌，申 基喆，長野孝俊，両角俊哉，小松康高，出分菜々衣，神谷洋介，北村正博，田口洋一郎，高柴正悟，湯本浩通，山下明子，吉永泰周，吉村篤利，河口浩之
  • Organizer: 第65回秋季日本歯周病学会学術大会
• [Presentation] 非アルコール性脂肪性肝炎由来肝細胞がんにおける歯周病の関与 (2022)
  • Author(s): 琢磨 遼，両角俊哉，松井嵩昌，山本裕子，結束貴臣，米田正人，野上麻子，小林 貴，杉原俊太郎，鎌田要平，田村宗明，光藤健司，中島 淳，三邉正人，小牧基浩
  • Organizer: 第65回秋季日本歯周病学会学術大会
• [Presentation] ラード摂取量の違いがラット唾液中IgAレベルに与える影響の検討 (2022)
  • Author(s): 山本裕子，井出 桃，両角俊哉，猿田樹理，坂口和歌子，東 雅啓，清水智子，槻木恵一
  • Organizer: 日本歯科衛生学会 第17回学術大会
• [Presentation] 短鎖脂肪酸経口摂取がラット唾液中IgA分泌速度に与える影響の検討 (2022)
  • Author(s): 山本裕子，高橋 徹，猿田樹理，坂口和歌子，両角俊哉，東 雅啓，槻木恵一
  • Organizer: 第1回日本唾液ケア研究会学術集会
• [Presentation] 医科歯科連携による歯周病と糖尿病のスクリーニング検査及びその有用性の検討 (2021)
  • Author(s): 平田貴久, 両角俊哉, 青木一孝, 三邉正人
  • Organizer: 第64回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病専門クリニックに通院 中の糖尿病患者における糖尿病と歯周病の病態の関連性 (2021)
  • Author(s): 山本裕子, 両角俊哉, 平田貴久,渕田慎也, 琢磨 遼, 三邉正人
  • Organizer: 第64回春季日本歯周病学会学術 大会
• [Presentation] 歯周病評価における最適検査部位の選定 ―項目反応理論 Graded response modelの応用― (2021)
  • Author(s): 両角俊哉, 野村義明, 福田光男, 花田信弘, 角田衣理加, 小林宏明, 三邉正人, 中村利明, 中 山洋平, 西村英紀, 野口和行, 沼部幸博, 小方頼昌, 齋藤 淳, 佐藤 聡, 関野 諭, 菅野直之, 菅谷 勉, 鈴木史彦, 多部田康一, 高橋慶壮, 高井英樹, 高柴正悟, 梅田 誠, 吉江弘正, 吉村 篤利, 吉成伸夫, 中川種昭
  • Organizer: 第64回春季日本歯周病学会学術大会
• [Presentation] トモシンセシス法を用いたパノラマX線画像における歯周組織所見の主観的および物理学的画質評価 (2021)
  • Author(s): 杉原俊太郎, 両角俊哉, 三邉正人
  • Organizer: 日本歯科保存学会2021年度春季学術大会(第154回)
• [Presentation] 歯周病のポケット選定における代表歯・部位の選定 (2021)
  • Author(s): 両角俊哉, 高柴正悟, 三邉正人, 野村義明, 福田光男, 花田信弘, 角田衣理加, 小林宏明,中 村利明, 中山洋平, 西村英紀, 野口和行, 沼部幸博, 小方頼昌, 齋藤 淳, 佐藤 聡, 関野 諭, 菅野直之, 菅谷 勉, 鈴木史彦, 多部田康一, 高橋慶壮, 高井英樹,梅田 誠, 吉江弘正, 吉村 篤利, 吉成伸夫, 中川種昭
  • Organizer: 第14回 日本口腔検査学会総会・学術大会
• [Presentation] トモシンセシス法を用いたパノラマX線画像における硬組織所見の主観的および物理学的画質評価 (2021)
  • Author(s): 杉原俊太郎, 両角俊哉, 香西雄介, 印南 永
  • Organizer: 第56回神奈川歯科大学学会総会
• [Presentation] 医科歯科連携による歯周病、糖尿病のスクリーニング検査とその有用性の検討 (2021)
  • Author(s): 平田貴久, 両角俊哉, 杉原俊太郎, 門田大地, 青木一孝
  • Organizer: 第56回神奈川歯科大学学会総会
• [Presentation] 歯周病ポケット検査における代表歯・部位の選定 (2021)
  • Author(s): 両角俊哉, 野村義明, 中川種昭, 沼部幸博, 菅谷 勉, 佐藤 聡, 野口和行, 吉成伸夫, 吉村 篤利, 西村英紀, 齋藤 淳, 福田光男, 小林宏明, 菅野直之, 多部田康一, 高橋慶壮, 梅田 誠, 高柴正悟, 三邉正人, 小方賴昌
  • Organizer: 第56回神奈川歯科大学学会総会
• [Presentation] 歯周基本治療講義における動画教材の有効性検討 (2021)
  • Author(s): 両角俊哉, 杉原俊太郎, 渕田慎也, 清水統太, 井上 允, 小牧基浩
  • Organizer: 神奈川歯科大学学会第167回例会
• [Presentation] 糖尿病専門クリニックに通 院中の糖尿病患者における糖尿病と歯周病の病態の関連性 第3報 (2019)
  • Author(s): 山本裕子, 両角俊哉, 青山典生, 平田貴久, 渕田愼也, 三辺正人
  • Organizer: 第62回春季日本歯周 病学会学術大会
• [Presentation] Effect of Ingesting Yogurt Fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on Influenza Virus-Bound Salivary IgA in Elderly People (2019)
  • Author(s): Yamamoto Y, Saruta J, Takahashi T, To M, Shimizu T, Morozumi T, Kubota N, Makino S, Kano H, Tsukinoki K
  • Organizer: 13th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health
  • Int'l Joint Research
• [Presentation] Smoking status and social nicotine dependence among members in Japanese Society of Periodontology (2019)
  • Author(s): Inagaki K, Oh H, Hanioka T, Fujii T, Morozumi T, Ito H, Yamamoto T, Morita M
  • Organizer: Tobacco Induced Diseases 15th Annual Conference
  • Int'l Joint Research
• [Presentation] 広汎型重度慢性歯周炎患者において歯周組織再生療法と局所矯正治療により改善を認 めた一症例 (2018)
  • Author(s): 両角俊哉,保苅崇大,野村 隆,久保田健彦,小松康高,高橋直紀,奥田一博,三辺正人,吉江弘 正
  • Organizer: 第61回春季日本歯周病学会学術大会
• [Presentation] 歯周病模型に対する従来法印象とデジタル印象法の再現性についての評価 (2018)
  • Author(s): 杉原俊太郎, 大野晃教, 井上絵理香, 清宮一秀, 丸尾勝一郎, 星 憲幸, 両角俊哉, 木本克彦, 三辺正人
  • Organizer: 第 61回秋季日本歯周病学会学術大会
• [Presentation] Biological response and clinical effect following one-stage full-mouth scaling and root planing (2018)
  • Author(s): Toshiya Morozumi
  • Organizer: 104TH Annual Meeting of the American Academy of Periodontology
  • Int'l Joint Research / Invited
• [Presentation] Expression of neprilysin in periodontitis-affected gingival tissues (2017)
  • Author(s): Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nohno K, Hokari T, Morozumi T, Yoshie H
  • Organizer: 16th International Congress of Periodontology of the International Academy of Periodontology
  • Int'l Joint Research
• [Presentation] Effectiveness of periodontal regenerative therapy using enamel matrix derivative, deproteinised bovine bone mineral with or without collagen membrane (2017)
  • Author(s): Kubota T, Nemoto Y, Nohno K, Morozumi T, Horimizu M, Yoshie H
  • Organizer: 16th International Congress of Periodontology of the International Academy of Periodontology
  • Int'l Joint Research
• [Presentation] 歯肉縁下細菌と血清抗体価を用いた慢性歯周炎進行の評価：24ヵ月多施設前向きコホート研究 (2017)
  • Author(s): 両角俊哉、角田衣理加、野村義明、中川種昭、野口和行、原 宜興、西村英紀、梅田 誠、 野口俊英、吉成伸夫、沼部幸博、伊藤公一、和泉雄一、小方頼昌、三邉正人、齋藤 淳、佐藤 聡、高橋慶壮、川浪雅光、花田信弘、高柴正悟、吉江弘正
  • Organizer: 第60回春季日本歯周病学会学術大会
• [Presentation] 広汎型重度慢性歯周炎患者において歯周基本治療と根分岐部病変治療（トンネリング）により改善を認めた一症例 (2017)
  • Author(s): 両角俊哉,保苅崇大,小松康高,久保田健彦,奥田一博,吉江弘正
  • Organizer: 第60回春季日本歯周病学会学術大会
• [Presentation] Clinical and three-dimensiona evaluation of combinational periodontal regenerative therapy using enamel matrix derivative, deproteinized bovine bone mineral with or without collagen membrane (2017)
  • Author(s): Kubota T, Nemoto Y, Nohno K, Nezu A, Horimizu M, Morozumi T, Yoshie H
  • Organizer: National Symposium OSTEOLOGY JAPAN
  • Int'l Joint Research
• [Presentation] 歯肉縁下細菌と血清抗体価による慢性歯周炎進行の予知判定：24ヵ月多施設前向きコホート研究 (2017)
  • Author(s): 両角俊哉,中川種昭,野口和行,原 宜興,西村英紀,梅田 誠,野口俊英,吉成伸夫,沼部幸博, 伊藤公一,和泉雄一,小方頼昌,三邉正人,齋藤 淳,佐藤 聡,高橋慶壮,川浪雅光,花田信弘, 高柴正悟,吉江弘正
  • Organizer: 日本歯科保存学会2017年度春季学術大会
• [Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの臨床および微生物学的効果 (2017)
  • Author(s): 保苅崇大,両角俊哉,小松康高,久保田健彦,吉江弘正
  • Organizer: 日本歯科保存学会2017年度春季学術大会
• [Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの臨床および生物学的効果 (2017)
  • Author(s): 保苅崇大,両角俊哉,小松康高,清水太郎,吉野敏明,田中真喜,田中良枝,久保田健彦,吉江 弘正
  • Organizer: 平成29年度新潟歯学会第1回例会
• [Presentation] Systemic and local biological response following one-stage full-mouth scaling and root planning (2017)
  • Author(s): Morozumi1 T, Yashima A, Gomi K, Ujiie Y, Izumi Y, Akizuki T, Mizutani K, Takamatsu H, Minabe M, Miyauchi S, Yoshino T, Tanaka M, Tanaka Y, Hokari T, Yoshie H
  • Organizer: 12th Asian Pacific Society of Periodontology
  • Int'l Joint Research
• [Book] エキスパートが初めて明かす技のバイブル！ インプラント周囲炎はEr:YAG Laserでこう治す！ (2022)
  • Author(s): 山本敦彦、両角俊哉、久保田健彦、浦野 智、猪子光晴、藤田 亨、富塚佳史、中西真大、小野晴彦
  • Total Pages: 108
  • Publisher: クインテッセンス出版
  • ISBN: 9784781209074
• [Book] 歯周治療のガイドライン 2022 (2022)
  • Author(s): 両角俊哉,他（特定非営利活動法人 日本歯周病学会 編）
  • Total Pages: 93
  • Publisher: 医歯薬出版
• [Book] 第3版臨床 歯周病学 (2020)
  • Author(s): 三辺正人,両角俊哉
  • Total Pages: 416
  • Publisher: 医歯薬出版
  • ISBN: 9784263458440
• [Book] 日本歯科評論別冊2019 歯科診療の幅を広げる医科との連携－保険算定要件から治療対応のポイントまで (2019)
  • Author(s): 三辺正人,山本裕子,両角俊哉
  • Total Pages: 144
  • Publisher: ヒョーロン・パブリッシャーズ
• [Book] 歯科衛生学辞典 (2019)
  • Author(s): 両角俊哉
  • Total Pages: 480
  • Publisher: 永末書店
  • ISBN: 9784816013683
• [Book] 患者さんのエイジングに備える 高齢者への歯周治療と口腔管理 (2018)
  • Author(s): 吉江弘正、両角俊哉（吉江弘正、吉成伸夫、米山武義 編）
  • Total Pages: 283
  • Publisher: インターアクション