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Study focusing on the involvement of periodontal disease in increased insulin resistance in gestational diabetes.

Research Project

Project/Area Number 17K11988
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionKagoshima University

Principal Investigator

HASEGAWA-NAKAMURA Kozue  鹿児島大学, 医歯学域歯学系, 助教 (00404492)

Co-Investigator(Kenkyū-buntansha) 橋口 千琴  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (10596860)
中村 利明  鹿児島大学, 医歯学域鹿児島大学病院, 講師 (60381183)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周病 / 妊娠性糖尿病 / 歯周病原細菌 / 糖代謝異常 / インスリン抵抗性 / 胎盤
Outline of Final Research Achievements

It was not indicated that periodontal disease is a risk factor for abnormal glucose tolerance in threatened premature labor. However, the presence of F. nucleatum, P. intermedia, and T. forsythia in chorionic tissues in women with TPL may be involved in abnormal glucose tolerance. In vitro study, it was shown that F. nucleatum LPS may increase the expression of inflammatory substances and induce insulin resistance in BeWo cells (placenta-derived cells). In vivo sutudy, it was suggested that apoptosis induced by periodontal pathogens in placenta might cause abnormal pregnant outcomes.

Academic Significance and Societal Importance of the Research Achievements

本研究結果より、歯周病原細菌が妊娠期における糖代謝異常と関連し、そのメカニズムとして胎盤で歯周病原細菌が炎症反応を引き起こすとともにインスリン抵抗性に関与する可能性が示唆された。このことは、歯周病と妊娠性糖尿病の関連に関する研究分野において、重要な知見となり得る。我々の研究結果により、胎盤に存在する歯周病原細菌が妊娠期における糖代謝異常のリスク因子となる可能性が示唆された。このことは、口腔内環境の改善が妊娠性糖尿病の発症・悪化リスクの低減につながる、という新しいアプローチを提供できると思われ、社会的にも有用な情報である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2021 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Effect of interleukin-1β on bone morphogenetic protein-9- induced osteoblastic differentiation of human periodontal ligament fibroblasts.2021

    • Author(s)
      Yukari EBE, Toshiaki NAKAMURA, Kozue HASEGAWA-NAKAMURA, and Kazuyuki NOGUCHI
    • Journal Title

      European Journal of Oral Sciences

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival recession defects in dogs2019

    • Author(s)
      Y Shirakata1, T Nakamura, Y Shinohara, K Nakamura-Hasegawa, C Hashiguchi, N Takeuchi, T Imafuji, A Sculean, K Noguchi
    • Journal Title

      Clinical Oral Investigations

      Volume: in press

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a new model for training of initial periodontal therapy2018

    • Author(s)
      町頭 三保、梅田 誠、野口 和行、中村 利明、白方 良典、中村 梢、迫田 賢二、瀬名 浩太郎、篠原 敬哉、橋口 千琴、田口 洋一郎
    • Journal Title

      Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)

      Volume: 60 Issue: 1 Pages: 44-51

    • DOI

      10.2329/perio.60.44

    • NAID

      130006594272

    • ISSN
      0385-0110, 1880-408X
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of Periodontal Pathogens in Chorionic Tissues of Pregnant Women Diagnosed with Threatened Premature Labor and Abnormal Glucose Tolerance2017

    • Author(s)
      Kozue Hasegawa-Nakamura, Toshiaki Nakamura, Masato Kamitomo Fumi Tateishi, Chikoto Hashiguchi, Kazuya Kawamata, Masayuki Hatae, Kazuyuki Noguchi
    • Journal Title

      日本歯周病学会会誌

      Volume: 59 Pages: 133-143

    • NAID

      130006105760

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects.2017

    • Author(s)
      Nakamura T, Shirakata Y, Shinohara Y, Miron RJ, Hasegawa-Nakamura K, Fujioka-Kobayashi M, Noguchi K.
    • Journal Title

      Clin Oral Investig.

      Volume: 印刷中 Issue: 9 Pages: 2671-2679

    • DOI

      10.1007/s00784-017-2069-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 妊娠マウスへの Porphyromonas gingivalis /Fusobacterium nucleatum 投与が 妊娠・出産へ与える影響2021

    • Author(s)
      中村梢、町頭三保、中村利明、野口和行
    • Organizer
      日本歯科保存学会2020年度春季学術大会第152回
    • Related Report
      2020 Annual Research Report
  • [Presentation] 広汎型重度慢性歯周炎に対し、経口抗菌療法を併用した歯周基本治療を行った1症例2019

    • Author(s)
      中村 梢、野口和行
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 広汎型重度慢性歯周炎に対し、経口抗菌療法を併用した歯周基本治療を行った1症例2019

    • Author(s)
      中村 梢、野口和行
    • Organizer
      令和元年度日本歯周病学会九州五大学 日本歯周病学会合同研修会
    • Related Report
      2019 Research-status Report
  • [Presentation] 糖代謝異常を有する切迫早産妊婦の絨毛膜組織での歯周病原細菌の検出2017

    • Author(s)
      中村梢, 中村利明, 上塘正人, 立石ふみ, 橋口千琴, 川俣和弥, 波多江正紀, 野口和行
    • Organizer
      九州5大学・臨床歯周病学会合同研修会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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