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Effect of ANGPTL2 on periodontal disease

Research Project

Project/Area Number 17K11997
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionAichi Gakuin University

Principal Investigator

Yamamoto Genta  愛知学院大学, 歯学部, 講師 (30421241)

Co-Investigator(Kenkyū-buntansha) 茂木 眞希雄  愛知学院大学, 薬学部, 准教授 (00174334)
三谷 章雄  愛知学院大学, 歯学部, 教授 (50329611)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsANGPTL2 / オートクライン / パラクライン
Outline of Final Research Achievements

Angiopoietin-like protein 2 (ANGPTL2) has been reported as a novel chronic inflammatory factor, suggesting the possibility of new therapeutic strategies for cancer and lifestyle-related diseases through its signal regulation. However, little is known about the involvement of ANGPTL2 in periodontal disease. The applicant conducted a study to clarify the role of ANGPTL2 in the pathogenesis of periodontal disease. The results suggest that stimulation of periodontopathogenic bacteria P. gingivalis LPS increases ANGPTL2 production from gingival epithelial cells, and that it is involved in prolonged chronic inflammation and periodontal tissue destruction through autocrine effects on gingival epithelial cells and paracrine effects on gingival fibroblasts.

Academic Significance and Societal Importance of the Research Achievements

歯周病において、「慢性炎症」を基盤とした全身疾患の発症や進展に寄与しているANGPTL2による制御が明らかとなれば、歯周病と全身疾患との関連性のメカニズムを解明するうえで有意義であり、本研究成果により、歯周病治療、口腔衛生指導ががん、糖尿病などの全身疾患の予防につながるとなれば、超高齢社会における医療費削減に大きな役割をなすと思われる。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells.2017

    • Author(s)
      Ohno T, Yamamoto G, Hayashi JI, Nishida E, Goto H, Sasaki Y, Kikuchi T, Fukuda M, Hasegawa Y, Mogi M, Mitani A.
    • Journal Title

      PLoS One

      Volume: 12(9) Issue: 9 Pages: 1-14

    • DOI

      10.1371/journal.pone.0184825

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯周病における組織破壊に関する免疫学的考察2017

    • Author(s)
      菊池 毅,岡部猪一郎,岡田康佑,大野 祐, 後藤久嗣,藤村岳樹,菱川敏光,山本弦太, 福田光男,三谷章雄
    • Journal Title

      日本歯周病学会雑誌

      Volume: 59(4) Pages: 185-190

    • NAID

      130006289521

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 歯肉上皮細胞においてアンジオポエチン様タンパク2はPorphyromonas gingivalis菌由来LPSによる炎症反応に関与する。2018

    • Author(s)
      大野祐、山本弦太、林潤一郎、西田英作、後藤久嗣、佐々木康行、菊池毅、福田光男、長谷川義明、三谷章雄
    • Organizer
      第13回日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] アンジオポエチン様タンパク2は歯肉上皮細胞において炎症反応を遷延化させる。2017

    • Author(s)
      大野祐、山本弦太、林潤一郎、西田英作、後藤久嗣、佐々木康行、菊池毅、長谷川義明、茂木眞希雄、福田光男、三谷章雄
    • Organizer
      第60回秋季日本歯周病学会学術大会(京都)
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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