| Project/Area Number |
17K11998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
相野 誠 愛知学院大学, 歯学部, 招へい教員 (20572811)
神谷 洋介 愛知学院大学, 歯学部, 講師 (70572808)
後藤 久嗣 愛知学院大学, 歯学部, 助教 (10783037)
小林 周一郎 愛知学院大学, 歯学部, 招へい教員 (80750190)
齋藤 正寛 東北大学, 歯学研究科, 教授 (40215562)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯槽骨再生 / 移植・再生医療 / NEBL |
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| Outline of Final Research Achievements |
There are various regenerative therapies for periodontal disease, which is highly prevalent in middle-aged and elderly people. There is a need for cell transplantation therapy in the periodontal disease category, but the method is currently poorly established. The function of NEBL as a bone marker molecular candidate for alveolar bone-derived osteoblasts that can be used for cell transplantation therapy in this study in the bone differentiation cascade needs to be further investigated in mice and rats. . In addition, it was clarified that the establishment of a method for culturing osteoblasts derived from alveolar bone of old rat alveolar bone is useful as a model animal in diseases associated with bone defects such as periodontal disease assuming middle-aged and elderly people.
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| Academic Significance and Societal Importance of the Research Achievements |
先行研究で使用したヒト歯槽骨由来骨芽細胞（human alveolar bone osteoblastic cell；HAOBs）は倫理問題やサンプリングの限界もあり実験群を十分に確保することができない問題があったが、マウス歯槽骨由来骨芽細胞（mouse alveolar bone osteoblastic cell；MAOB）を使用したことで、歯周病をはじめとする、骨欠損を伴う疾患においてのモデル動物として有用である。
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