| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Lysosomes are responsible for intracellular digestion and are essential for nutrient uptake, clearance of unnecessary substances and biological defense. Function of lysosomes is closely related to many diseases including neurodegenerative diseases and cancer, and aging. LAMP2 (lysosomal-associated membrane protein 2) is the abundant protein component of lysosome membrane and important for lysosome function. In the present study, the homophilic interaction of LAMP2 was studied using expanded genetic code technologies that generate photo-crosslinking and/or steric hindrance at specified interfaces. The homophilic interaction of LAMP2 was found to be important for the LAMP2-dependent chaperone-mediated autophagy.
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