• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of oral environmental factors involved in prevention of diabetic nephropathy and development of oral version prevention program

Research Project

Project/Area Number 17K12009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionTokushima Bunri University (2018-2020)
The University of Tokushima (2017)

Principal Investigator

Yoshioka Masami  徳島文理大学, 保健福祉学部, 教授 (90243708)

Co-Investigator(Kenkyū-buntansha) 長井 幸二郎  徳島大学, 病院, 講師 (40542048)
柳沢 志津子  徳島大学, 大学院医歯薬学研究部(歯学域), 講師 (10350927)
白山 靖彦  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (40434542)
日野出 大輔  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (70189801)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords歯科保健指導 / 歯科保健行動 / 糖尿病 / 肥満 / 糖尿病性腎症 / 重症化予防 / 臨床指標 / 口腔健康状態 / 糖尿病外来患者 / 保健指導 / 食習慣 / コホート研究 / 口腔保健行動 / 歯科保健 / 食事習慣 / 特定健診 / メタボリックシンドローム / 歯周病 / 口腔 / 予防プログラム
Outline of Final Research Achievements

In this study, we investigated the association between oral health status and diabetic nephropathy-related indices in individuals who received public medical checkups and oral examination. As a result, a significant correlation between the periodontal score and renal function index in middle-aged men. We also investigated the association between oral health behavior and diabetes-related indices in patients with type 2 diabetes. Our finding suggested that toothbrushing before bedtime every night is associated with reduced risk of obesity, and that eating slowly and chewing well are advantageous for glycemic control in patients with type 2 diabetes. Preliminary intervention studies have suggested that oral health guidance might be effective not only in oral health behavior but also in periodontal status and renal function. In the future, we would like to analyze the data obtained in the cohort study and clarify the factors that influence the prognosis of diabetes-related indicators.

Academic Significance and Societal Importance of the Research Achievements

本研究では糖尿病の進行に影響を及ぼす口腔関連、食関連の影響因子を明らかにした。これにより糖尿病の重症化予防という観点からの歯科保健指導の根拠となる知見を得ることができた。また、研究を通じて「口腔保健が糖尿病性腎症の重症化予防と関連すること」を地域の保健担当者や糖尿病患者に発信することができた。今後さらに研究が進展し、根拠に基づく保健指導や口腔管理が糖尿病性腎症の発症や重症化の抑止力となることが検証されたならば、患者のQOL向上はもちろん、透析治療に費やす社会的コストの削減に歯科が貢献できることになり、その意義は極めて大きいと考えている。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Association between diabetes-related clinical indicators and oral health behavior among patients with type 2 diabetes2021

    • Author(s)
      Masami Yoshioka, Yuichiro Kawashima, Yoshihiko Noma, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai, and Daisuke Hinode
    • Journal Title

      The Journal of Medical Investigation

      Volume: 68 Pages: 140-147

    • NAID

      130008038410

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men2020

    • Author(s)
      Yoshioka Masami、Okamoto Yoshifumi、Murata Masahiro、Fukui Makoto、Yanagisawa Shizuko、Shirayama Yasuhiko、Nagai Kojiro、Hinode Daisuke
    • Journal Title

      Journal of Diabetes Research

      Volume: - Pages: 1-5

    • DOI

      10.1155/2020/4042129

    • NAID

      120006999401

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 糖尿病外来患者の口腔健康状態/歯科保健行動とLDLコレステロールとの関連性2021

    • Author(s)
      吉岡昌美、川島友一郎、福井 誠、柳沢志津子、中江弘美、十川悠香、日野出大輔
    • Organizer
      日本口腔衛生学会特別大会(第24回日本歯科医学会学術大会)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病コントロールを表す臨床指標と歯科保健行動との関連性2020

    • Author(s)
      吉岡昌美,川島友一郎,福井 誠、柳沢志津子,日野出大輔
    • Organizer
      第69 回日本口腔衛生学会・総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病外来患者に対する歯科保健指導の効果の検討2020

    • Author(s)
      吉岡昌美,福井 誠、中江弘美、十川悠香、日野出大輔
    • Organizer
      第31回近畿・中国・四国口腔衛生学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病外来患者の歯科的課題-口腔内の自覚症状と歯科保健行動との関連-2020

    • Author(s)
      吉岡 昌美、川島 友一郎、野間 喜彦、日野出 大輔、柳沢 志津子、白山 靖彦
    • Organizer
      第65回四国公衆衛生学会総会平成31年度令和元年度四国公衆衛生研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] 糖尿病患者の食行動と口腔環境との関連性2019

    • Author(s)
      吉岡 昌美,川島 友一郎, 南 明香, 福井 誠,柳沢 志津子,日野出 大輔
    • Organizer
      第68回日本口腔衛生学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Association between Periodontal Status and Renal Function in Middle-aged Men2019

    • Author(s)
      Masami Yoshioka, Yoshifumi Okamoto, Daisuke Hinode
    • Organizer
      第97回IADR(国際歯科研究学会)総会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病外来患者の食習慣と口腔保健との関連2019

    • Author(s)
      吉岡昌美 川島友一郎  野間喜彦 南明香 日野出大輔  柳沢志津子 白山靖彦
    • Organizer
      第64回四国公衆衛生学会総会平成30 年度四国公衆衛生研究発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 糖尿病患者の食行動と口腔環境との関連性2019

    • Author(s)
      吉岡昌美, 川島友一郎, 南明香, 福井誠,柳沢志津子,白山靖彦,日野出大輔
    • Organizer
      第68回日本口腔衛生学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Association between Periodontal Status and Renal Function2019

    • Author(s)
      Masami Yoshioka, Yoshifumi Okamoto, Daisuke Hinode, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai
    • Organizer
      2019 IADR/AADR/CADR General Session
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯周病とメタボリックシンドローム関連指標との関連性の検討2018

    • Author(s)
      吉岡昌美 岡本好史 村田昌弘 岸彰 岡部仁史 片山美寿江 日野出大輔
    • Organizer
      第63回四国公衆衛生学会総会平成29年度四国公衆衛生研究発表会
    • Related Report
      2017 Research-status Report
  • [Book] Recent Advances of Sarcopenia and Frailty in CKD; Akihiko Kato, Eiichiro Kanda, Yoshihiko Kanno (Eds.) ; Oral Health Management for the Prevention of Sarcopenia and Frailty, p179-1962020

    • Author(s)
      Masami Yoshioka
    • Total Pages
      18
    • Publisher
      Springer
    • ISBN
      9789811523649
    • Related Report
      2019 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi