Elucidation of the taste disorders using gene expression analysis

Research Project

Project/Area Number	17K12020
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Social dentistry
Research Institution	Tokai University
Principal Investigator	DENDA Yuya 東海大学, 医学部, 助教 (70734424)
Co-Investigator(Kenkyū-buntansha)	太田嘉英東海大学, 医学部, 教授 (60233152) 徳田裕東海大学, 医学部, 客員教授 (20163975) 鬼塚真仁東海大学, 医学部, 准教授 (80366012) 笹野高嗣東北大学, 歯学研究科, 名誉教授 (10125560) 庄司憲明東北大学, 大学病院, 講師 (70250800) 佐藤しづ子東北大学, 歯学研究科, 助教 (60225274)
Project Period (FY)	2017-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	味覚障害 / 化学療法 / 薬物療法 / 味覚受容体 / 乳癌 / 造血器腫瘍 / 造血幹細胞移植 / 乳がん
Outline of Final Research Achievements	The mean incidence of subjective taste alterations in patients with breast cancer following chemotherapy was 53%.Taste alterations decreased to about 9.0% immediately before the next cycle. A multivariate analysis indicated that age and body surface area influenced taste alterations. The mean incidence of subjective taste alterations in patients received Hematopoietic stem cell transplant was 68%. Taste alterations decreased to 10% after 12 months. A multivariate analysis indicated that oral mucositis and saliva volume influenced taste alterations. There was no significant difference in the expression of taste receptors comparing before and after chemotherapy.
Academic Significance and Societal Importance of the Research Achievements	がん化学療法中の味覚の喪失は低栄養、体重減少に加え、有害事象の長期化、QOLの低下、治療抵抗性の低下を惹起し、延いては治療効果の低下を引き起こす場合がある。化学療法による味覚障害の研究により新たな支持療法の開発や治療期間中の患者負担軽減につながることが期待される。