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Cell Biology and epidemiological studies of non-obese metabolic syndrome prevention focused on periodontal disease study

Research Project

Project/Area Number 17K12022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionNihon University

Principal Investigator

KAWATO Takayuki  日本大学, 歯学部, 教授 (50386075)

Co-Investigator(Kenkyū-buntansha) 前野 正夫  日本大学, 歯学部, 特任教授 (60147618)
中井 久美子  日本大学, 歯学部, 助教 (50736725)
田中 秀樹  日本大学, 歯学部, 准教授 (90434076)
森田 十誉子  公益財団法人ライオン歯科衛生研究所(研究部研究開発室), 研究部研究開発室, 主任研究員 (00597247)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯周病 / 肥満 / メタボリックシンドローム / 脂肪細胞 / 血管新生因子 / 高血圧 / 高血糖 / 細胞外基質タンパク
Outline of Final Research Achievements

In the cross-sectional study, periodontal disease was associated with the accumulation of hypertension, hyperglycemia or dyslipidemia in obese and non-obese subjects, whereas the longitudinal study revealed this association was observed only in obese subjects. These epidemical studies indicate periodontal disease is associated an accumulation of cardiovascular metabolic risk factors in non-obese individual, but its causal association is still unclear.
In cell biological studies, inflammatory cytokines suppressed the expression of collagenase in mature adipocytes and the expression of its inhibitor in premature adipocytes. The expression of angiogenic factors in premature adipocytes was increased, whereas that in mature adipocytes was decreased, by inflammatory cytokines, respectively. This finding suggests inflammatory cytokines involves in excess expansion and dysfunction of adipose tissue via an alteration of angiogenesis and collagen turnover in premature and mature adipocytes.

Academic Significance and Societal Importance of the Research Achievements

動脈硬化性疾患のリスクの重複陽性化と歯周病の関連性は肥満者に認められ,リスク別では,肥満者では高血糖,非肥満者では高血圧の陽性化が歯周病と関連する可能性が示唆された。動脈硬化性疾患のリスクの改善には,各リスクの状況に加えて歯周病と肥満の有無についても考慮する必要があると考えられた。炎症性サイトカインは,成熟脂肪細胞の細胞外基質代謝と血管新生の調節因子の発現を抑制して脂肪組織の陳宮化を,未成熟脂肪細胞ではこれらを促進して脂肪蓄積を誘導する可能性が示唆された。炎症性サイトカインは,脂肪組織の肥大化過程の初期と後期にそれぞれ異なる形で,動脈硬化性疾患のリスクにつながる変化もたらすと考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effect of Periodontitis and Toothbrushing Frequency on Obesity Onset: A Cohort Study.2019

    • Author(s)
      Morita T, Yamazaki Y, Seto M, Yamamoto T, Nakai K, Tanaka H, Ozaki M, Koshi R, Maeno M, Kawato T
    • Journal Title

      Med Sci Monit.

      Volume: 25 Pages: 9712-9720

    • DOI

      10.12659/msm.917356

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous compressive force induces the differentiation of osteoclasts with high levels of inorganic dissolution.2019

    • Author(s)
      Matsuike R, Nakai K, Tanaka H, Ozaki M, Kanda M, Nagasaki M, Shibata C, Mayahara Kotoe, Tanabe N, Koshi R, Nakajima A, Kawato T, Maeno M, Shimizu N, Motoyoshi M
    • Journal Title

      Medical Science Monitor

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 職域成人における口腔清掃習慣と歯周ポケット形成との関連性-産業歯科健診情報を活用したコホート研究-2018

    • Author(s)
      山崎洋治, 森田十誉子, 藤春知佳, 川戸貴行, 前野正夫
    • Journal Title

      日本口腔衛生学会雑誌

      Volume: 68 Pages: 21-27

    • NAID

      130006405639

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Continuous application of compressive force induces fusion of osteoclast-like RAW264.7 cells via upregulation of RANK and downregulation of LGR42018

    • Author(s)
      Matsuike R, Tanaka H, Nakai K, Kanda M, Nagasaki M, Murakami F, Shibata C, Mayahara K, Nakajima A, Tanabe N, Kawato T, Maeno M, Shimizu N
    • Journal Title

      Life Science

      Volume: 201 Pages: 30-36

    • DOI

      10.1016/j.lfs.2018.03.038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 炎症性サイトカインが脂肪細胞の血管新生因子の発現に及ぼす影響2019

    • Author(s)
      柴田知佳,中井久美子,柏木 勝,小口久雄,唐鎌史行,北見 聡, 田中秀樹,前野正夫,川戸貴行
    • Organizer
      第68回日本口腔衛生学会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Compressive force induces fusion of osteoclast-like RAW264.7 cells2018

    • Author(s)
      Matsuike R, Tanaka H, Nakai K, Mayahara K, Kawato T, Maeno M, Shimizu N
    • Organizer
      96th General Session & Exhibition of IADR
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非肥満者における歯周病と心血管リスク因子との関連性に 関する横断研究2018

    • Author(s)
      森田十誉子,山崎洋治,藤春知佳,川戸貴行,前野正夫
    • Organizer
      第67回日本口腔衛生学会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 持続的な圧迫力は破骨細胞の分化を促進する2018

    • Author(s)
      松生理恵子,田中秀樹,中井久美子,岡 仁, 原田修成,飯田隆文,前野正夫, 清水典佳,川戸貴行
    • Organizer
      第67回日本口腔衛生学会・総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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