| Project/Area Number |
17K12027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Osaka Dental University (2019)
Kanagawa Dental College (2017-2018) |
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Principal Investigator |
Goda Seiiji 大阪歯科大学, 歯学部, 教授 (70351476)
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| Co-Investigator(Kenkyū-buntansha) |
井上 博 大阪歯科大学, 歯学部, 講師 (10330143)
佐藤 武則 神奈川歯科大学, 大学院歯学研究科, 講師 (40638904)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性歯周炎 / TIMP / ｂFGF / bFGF / p38 MAP kinase / 歯周再生 / 歯肉線維芽細胞 / コラーゲン分解能 / TIMP-1 / p38MAP kinase / 歯学 / シグナル伝達 |
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| Outline of Final Research Achievements |
We studied the production of Tissue inhibitor of matrix metalloproteinases (TIMP) in gingival fibroblasts, which is an endogenous extracellular matrix degrading enzyme inhibitor that has been attracting attention as an anti-inflammatory effect. As a result, TIMP-1 production in gingival fibroblasts was enhanced by stimulation with bFGF, which is a cytokine involved in wound healing and periodontal tissue regeneration. As for the TIMP-1 production of gingival fibroblasts stimulated with bFGF, it was revealed by an experiment using an inhibitor and siRAN knockdown that the p38 MAP kinase regulates TIMP-1 production.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究の意義は細胞シグナル伝達機構の検討によりp38MAP kinaseが内因性の細胞外マトリックス分解酵素阻酵素であるTIMP-1の制御機構としての役割を解明出来れば、TIMP-1の産生を選択的に増強させ、MMP-1の機能を抑制する事が可能となり、内因性の抗慢性歯周炎抑制作用が明らかとなる。
波及効果はさらに研究が進めば、慢性歯周炎の画期的な薬剤の開発となり、安全で局所に効率よく作用する慢性歯周炎治療薬の開発につながり慢性歯周炎だけでなく関連している心筋梗塞や糖尿病などの生活習慣病の治療に役立つと考えられる。そうすれば国民の健康増進に向けて大きく前進することが出来る。
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