Tobacco cessation intervention for oral diseases

• Project/Area Number: 17K12033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Nagao Toru 愛知学院大学, 歯学部, 教授 (90261007)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔疾患 / 禁煙支援 / 口腔がん予防 / 歯周病 / インプラント / タバコ / 喫煙 / 禁煙介入 / 口腔白板症 / ニコチンパッチ / コチニン / 口腔衛生学 / 禁煙 / 介入 / 口腔前がん病変

Outline of Final Research Achievements

A total of 74 patients were enrolled in the study. All dental specialists who participated in the trial completed an e-learning Japan Smoking Cessation Training Outreach Project (J-STOP) tobacco cessation education programme. Tobacco cessation intervention was implemented for 8 weeks with or without nicotine replacement therapy with follow-up for 12 months.
The mean biochemically confirmed tobacco abstinence rate for the tobacco cessation intervention group (n=61) was 37.7% at month 3, 34.4% at month 6, and 32.8% at month 12. Among the periodontal parameters, patients in the smoking cessation support program led by dental professionals showed more improvement in bleeding on probing (BOP) after scaling and root planing compared to the continued smoking group.

Academic Significance and Societal Importance of the Research Achievements

WHOは、すべての歯科医療従事者は禁煙支援によりタバコ関連口腔疾患のコントロールに取り組むべきとしている。それにもかかわらず世界中の歯科医療の現場ではいまだ禁煙支援は進んでいない。本介入研究では、禁煙に関するeラーニングコースを修了した歯科医師が歯科治療を受けている患者に直接禁煙介入することに高い有効性があることを示した。医科の禁煙治療と同等の禁煙継続率で、歯周疾患の改善効果を得た。
歯科医師自身が日常臨床の中で生活習慣病の最大のリスク因子である喫煙習慣の改善に関与する意義は大きい。本結果は歯科診療の場での保険を使った禁煙治療の適応拡大の提言のエビデンスになる。

Research Products

• [Journal Article] A multicentre tobacco cessation intervention study in the dental setting in Japan (2021)
  • Author(s): Nagao Toru、Fukuta Jinichi、Hanioka Takashi、Nakayama Yohei、Warnakulasuriya Saman、Sasaki Tadaaki、Shiota Makoto、Ohno Keisuke、Ishigaki Yoshiki、Satomura Kazuhito、Hashimoto Shuji、Goto Mitsuo、Seto Kanichi
  • Journal Title: International Dental Journal Volume: - Issue: 1 Pages: 1-10
  • DOI: 10.1016/j.identj.2021.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A multicenter prospective cohort study on the effect of smoking cessation on periodontal therapies in Japan (2021)
  • Author(s): Nakayama Y、Mizutani K、Tsumanuma Y、Yoshino H、Aoyama N、Inagaki K、Morita M、Izumi Y、Murakami S、Yoshimura H、Matsuura T、Murakami T、Yamamoto M、Yoshinari N、Mezawa M、Ogata Y、Yoshimura A、Kono K、Maruyama K、Sato S、Sakagami 、Ito H、Numabe Y、Nikaido M、Hanioka T et al.
  • Journal Title: Journal of Oral Science Volume: 63 Issue: 1 Pages: 114-118
  • DOI: 10.2334/josnusd.20-0288
  • NAID: 130007959197
  • ISSN: 1343-4934, 1880-4926
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 口腔疾患に対する禁煙の効果：多施設共同研究 (2018)
  • Author(s): 1.長尾徹，瀬戸晥一，福田仁一，栗田賢一，佐藤泰則，北川善政，草間幹夫，渡邉文彦，塩田 真，和泉雄一，二階堂雅彦，宮崎秀夫，埴岡 隆，今井 裕，藤内 祝
  • Journal Title: 日本歯科医学会雑誌 Volume: 37 Pages: 52-57
  • Open Access
• [Journal Article] 歯科・口腔疾患の喫煙患者対応 (2018)
  • Author(s): 長尾 徹
  • Journal Title: 医学のあゆみ Volume: 265 Pages: 877-880
• [Journal Article] 口腔潜在的悪性疾患の概念と口腔がん予防 (2018)
  • Author(s): 前田初彦，長尾 徹
  • Journal Title: 日本歯科医師会雑誌 Volume: 71 Pages: 19-28
• [Journal Article] A national opinion study supports tobacco cessation by oral health professionals in Japan (2017)
  • Author(s): 5.Nagao T, Fukuta J, Seto K, Saigo K, , Hanioka T, Kurita K, Tonai I, Yamashiro M, Kusama M, Satomura K, Izumi Y, Mizutani K, Aoyama N, Tsumanuma Y, Imai Y, Ishigaki Y, Nikaido M, Yoshino H, Sugai T, Kawana H, Hamada S, Matsuo A, Miura K. on behalf of the Tobacco Cessation Intervention Study for Oral Diseases (TISOD)
  • Journal Title: Translational Research in Oral Oncology Volume: ２ Pages: 1-8
  • DOI: 10.1177/2057178x17710416
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Creating a smoke-free society for members of the Japanese Society of Oral and Maxillofacial Surgeons (2017)
  • Author(s): 長尾 徹，佐藤泰則，柴原孝彦，石垣佳希，楠川仁悟，依田哲也
  • Journal Title: Japanese Journal of Oral and Maxillofacial Surgery Volume: 63 Issue: 10 Pages: 478-489
  • DOI: 10.5794/jjoms.63.478
  • NAID: 130006258032
  • ISSN: 0021-5163, 2186-1579
  • Peer Reviewed
• [Presentation] 口腔がんの早期発見と予防－口腔外科の立場から (2020)
  • Author(s): 長尾 徹
  • Organizer: 第31回日本臨床口腔病理学会総会学術大会
  • Invited
• [Presentation] Risk management for oral cancer. (2019)
  • Author(s): Toru Nagao
  • Organizer: BANGLADESH ORAL CANCER SOCIETY CONFERENCE (BOCSCON 2019)
  • Int'l Joint Research / Invited
• [Presentation] Early and late implant loss among smokers according to a large-scale survey in Japan (2019)
  • Author(s): Nagao T, Fukuta J, Sugai T, Kawana H， Matsuo A, Hamada S, Miura K, Seto K
  • Organizer: 15th Annual TID Conference on Tobacco Induced Diseases.
  • Int'l Joint Research
• [Presentation] 受動喫煙の小児への影響について (2019)
  • Author(s): 長尾 徹
  • Organizer: 第31回日本小児口腔外科学会総会・学術大会
  • Invited
• [Presentation] Management of oral cancer and tobacco control (2018)
  • Author(s): Nagao T
  • Organizer: Mandalay Dental Conference (Myanmar)
  • Int'l Joint Research / Invited
• [Presentation] Tobacco cessation intervention study for oral diseases. A national opinion study supports tobacco cessation by oral health professionals in Japan (2018)
  • Author(s): Nagao T
  • Organizer: アジア口腔顎顔面外科学会総会
  • Int'l Joint Research
• [Presentation] Tobacco and alcohol misuse and risk of oral cancer. (2017)
  • Author(s): Nagao T
  • Organizer: Bangladesh Oral Cancer Society Conference
  • Int'l Joint Research / Invited
• [Presentation] Tobacco smoking and risk of oral cancer: a national survey in Japan. (2017)
  • Author(s): Nagao T
  • Organizer: Trainees Conference Asian Association for Oral and Maxillofacial Surgeons 2017
  • Int'l Joint Research / Invited
• [Presentation] Tobacco cessation activities of the Japanese Society of Oral-Maxillofacial Surgeons. (2017)
  • Author(s): Nagao T
  • Organizer: IADR 11th World Congress on Preventive Dentistry (WCPD)
  • Int'l Joint Research / Invited
• [Remarks] 日本歯科医学会プロジェクト研究「口腔疾患に対する禁煙の効果：多施設共同研究」
  • URL: http://www.jamfi.net/tisod//index.html