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The mechanisms of flavor recognition related to pleasure of food consumption in the CNS

Research Project

Project/Area Number 17K12054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionMeikai University

Principal Investigator

Mizoguchi Naoko  明海大学, 歯学部, 講師 (00548919)

Co-Investigator(Kenkyū-buntansha) 小林 真之  日本大学, 歯学部, 教授 (00300830)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords風味 / 脳神経科学 / 光学計測 / 神経科学 / 味覚 / 嗅覚
Outline of Final Research Achievements

Elderly people are at high risk of suffering from dysphagia (having feeding/swallowing difficulty) in Japan which is a markedly ‘super-aged society’. The sensation of flavor could be useful as a motivator keeping QOL and an aid in the rehabilitation. Flavor of foods is known a combination of smell, taste, texture, and more. However, little is known whether and how flavor sensory inputs converged in the CNS. To address these issues, we observed rodents cortical responses to either or both of two stimuli, odorants and tastants, by in vivo optical imaging with flavoprotein autofluorescence or voltage sensitive dye. These results suggest that partial of the gustatory and olfactory information was integrated in anterior insular cortex, and intracellular signaling factors were also involved it.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会である我が国の人口動態統計では,死亡原因について肺炎と誤嚥性肺炎を分けて集計するようになっている。高齢者の肺炎による死亡の内訳として誤嚥性肺炎が占める割合が高いためであるが, その背景には主なリスク因子として摂食嚥下障害が存在すると考えられている。誤嚥性肺炎および摂食嚥下障害について理解を深めるとともに,予防法や医療介護を含めた対応方法の充実が期待される。本研究成果で得られた風味認識に関わる知見は,それらに関わる科学的根拠の一つとして応用できると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Optogenetic stimulation of cholinergic fibers for the modulation of insulin and glycemia2021

    • Author(s)
      Fontaine Arjun K.、Ramirez David G.、Littich Samuel F.、Piscopio Robert A.、Kravets Vira、Schleicher Wolfgang E.、Mizoguchi Naoko、Caldwell John H.、Weir Richard F. ff.、Benninger Richard K. P.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-83361-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV2021

    • Author(s)
      Fontaine Arjun K.、Futia Gregory L.、Rajendran Pradeep S.、Littich Samuel F.、Mizoguchi Naoko、Shivkumar Kalyanam、Ardell Jeffrey L.、Restrepo Diego、Caldwell John H.、Gibson Emily A.、Weir Richard F. ff
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-83280-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Olfactory signals from the main olfactory bulb converge with taste information from the chorda tympani nerve in the agranular insular cortex of rats.2020

    • Author(s)
      Mizoguchi N, Muramoto K, Kobayashi M.
    • Journal Title

      Pflugers Archiv - European Journal of Physiology

      Volume: 472(6) Issue: 6 Pages: 721-732

    • DOI

      10.1007/s00424-020-02399-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食べる意欲に欠かせない風味認識の中枢神経機構の解明2017

    • Author(s)
      溝口 尚子
    • Journal Title

      アグリバイオ

      Volume: 1(8) Pages: 894-895

    • Related Report
      2017 Research-status Report
  • [Presentation] 味やニオイの刺激で変わる!動物の脳活動2021

    • Author(s)
      溝口尚子
    • Organizer
      第30回日本バイオイメージング学会 学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 風味形成によるマウス大脳皮質での味およびニオイ情報処理領域の変化 Flavor formation affects the cortical representation of signal processing for odor and taste in mouse2019

    • Author(s)
      小峰 雄介、溝口 尚子、坂下 英明、村本 和世
    • Organizer
      NEURO 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Changes of neural activity in mouse insular cortex by the associative learning of taste and odor2018

    • Author(s)
      小峰 雄介、溝口 尚子、坂下 英明、村本 和世
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Visualization of odor- and taste-evoked cortical responses by in vivo optical imaging with flavoprotein autofluorescence2018

    • Author(s)
      小峰 雄介、溝口 尚子、坂下 英明、村本 和世
    • Organizer
      第95回 日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] An intracortical connection among somatosensory areas makes higher complemental processing for orofacial sensation in rat.2017

    • Author(s)
      溝口 尚子、箕田 碧、須田 直人、村本 和世
    • Organizer
      Neuroscience 2017 (北米神経科学会)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 第4版 イラストでわかる歯科医学の基礎2021

    • Author(s)
      天野 修、池尾 隆、石原 和幸、小川 祐三、川端 重忠、岸野 万伸、城戸 瑞穂、佐藤 元、住友 倫子、田畑 純、堂前 英資、長谷 則子、西村 康、溝口 尚子、山口 雅也、吉田 篤、李 昌一
    • Total Pages
      312
    • Publisher
      永末書店
    • ISBN
      9784816013935
    • Related Report
      2021 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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