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Involvement of clock genes in aging of salivary glands

Research Project

Project/Area Number 17K12059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionNihon University

Principal Investigator

ARIKAWA Kazumune  日本大学, 松戸歯学部, 教授 (50318325)

Co-Investigator(Kenkyū-buntansha) Bhawal Ujjal  日本大学, 松戸歯学部, 助教 (50433339)
田口 千恵子  日本大学, 松戸歯学部, 専修研究員 (80434091)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords唾液腺 / 抗加齢 / ドライマウス / 老化 / 口腔乾燥 / 時計遺伝子 / DEC1 / 体内時計 / 唾液 / 高齢者 / 加齢 / DEC1
Outline of Final Research Achievements

Difficulty swallowing is quite common among the elderly. Aging is a normal physiological phenomenon that affects almost all organs including the salivary glands. The purpose of this study is to elucidate salivary function disparities in submandibular gland aging profiles focusing on two major areas - microRNAs (miRNAs) and their target genes - that are most significantly affected in the aging process. With the comprehensive analysis of mRNAs and miRNAs, a great number of pairs have been identified, suggesting abnormally expressed miRNAs have functions in the salivary glands aging, and the function may be achieved through the post-transcriptional regulation of certain genes on the related pathways. Transcription factor DEC1 strongly repressed the promoter activity of E-cadherin. We further identified a possible DEC-response element in the E-cadherin promoter region and confirmed the direct binding of DEC1 to that element providing feedback on the aging mechanism of salivary glands.

Academic Significance and Societal Importance of the Research Achievements

高齢化に伴う唾液分泌障害者の増加は歯周病のリスクを上げるだけではなく、嚥下障害や誤嚥性肺炎の発症を招くなど、全身にも悪影響を与える。唾液腺樹状細胞が唾液腺健康維持に重要な働きをしていることが明らかになり、シェーグレン症候群や加齢など唾液腺疾患の発症機序の解明にも大きく貢献することが期待されている。本研究において、唾液腺の老化のメカニズムを解明するだけでなく、唾液分泌障害の診断や対処法の確立に役立つと思われる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (22 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 生涯歯科医療費の推計2020

    • Author(s)
      小椋正之,有川量祟
    • Journal Title

      日本歯科医療管理学会雑誌

      Volume: 54(4) Pages: 234-236

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CAD/CAM冠の現状等について2020

    • Author(s)
      和田康志,田口千恵子,田辺隆 ,川上智史、疋田一洋,村山憲作,田北行宏,岡田優一郎,山口秀紀,有川量崇
    • Journal Title

      日本歯科医療管理学会雑誌

      Volume: 54(4) Pages: 237-241

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of DEC1 in cervical cancer cells involving overexpression and apoptosis2020

    • Author(s)
      Sato F, Bhawal UK, Sugiyama N, Osaki S, Oikawa K, Muragaki Y
    • Journal Title

      Clocks & Sleep

      Volume: 2(1) Issue: 1 Pages: 26-38

    • DOI

      10.3390/clockssleep2010004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ナノバブル水を応用した歯科用チェアユニット給水システムの汚染対策の検討2019

    • Author(s)
      田口千恵子, 齋藤真規, 小林良喜, 岡田優一郎, 内山敏一, 後藤田宏也, 金田隆, 有川量崇
    • Journal Title

      日大口腔科学

      Volume: 45(2) Pages: 105-109

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 千葉県成人歯科健診 (歯周疾患検診) からみた県民の歯と口腔について2019

    • Author(s)
      鈴木英明, 田口千恵子, 和田康志, 山田孝, 村山憲作, 鈴木克彰, 中村茂, 岡田優一郎, 黒木俊一, 山口秀紀, 有川量崇
    • Journal Title

      日大口腔科学

      Volume: 45(4) Pages: 155-163

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with low‐level sodium fluoride on wound healing and the osteogenic differentiation of bone marrow mesenchymal stem cells2019

    • Author(s)
      Bhawal Ujjal K., Li Xiaoyan, Suzuki Masatoshi, Taguchi Chieko, Oka Shunichi, Arikawa Kazumune, Tewari Nitesh, Liu Yi
    • Journal Title

      Dental Traumatology

      Volume: ー Issue: 3 Pages: 1-1

    • DOI

      10.1111/edt.12532

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] <b>Circadian Expression of Differentiated Embryonic Chondrocytes Expressed Genes 1 </b><b>and 2 in Human Oral Squamous Cell Carcinoma HSC-3 Cells </b>2018

    • Author(s)
      Kazumune Arikawa,Fengzhu Zhang,,Chieko Taguchi,Ujjal K. Bhawal
    • Journal Title

      International Journal of Oral-Medical Sciences

      Volume: 17 Issue: 1 Pages: 33-37

    • DOI

      10.5466/ijoms.17.33

    • NAID

      130007403263

    • ISSN
      1347-9733, 2185-4254
    • Year and Date
      2018-06-25
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 水素水の抗炎症作用による口腔粘膜炎の治療・予防効果の検討2018

    • Author(s)
      竹内麗理,有川量崇,田口千恵子,末光正昌,森川美雪,丸山満博,渡邊信幸,久山佳代,平塚浩一
    • Journal Title

      日大口腔科学

      Volume: 44(2) Pages: 39-46

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 上顎前歯部に関する審美評価2018

    • Author(s)
      田口千恵子, 有川量崇, 小林清吾
    • Journal Title

      日大口腔科学

      Volume: 44(1) Pages: 8-15

    • Related Report
      2018 Research-status Report
  • [Journal Article] 高齢者の口腔環境に対する中鎖脂肪酸とビタミンDを含有するオイルの効果の検討2018

    • Author(s)
      有川量崇,谷野 弦,田口千恵子,竹内麗理,小林良喜,内山敏一, Ujial K.Bhawal,那須郁夫
    • Journal Title

      日本口腔ケア学会雑誌

      Volume: 12/ 2 Pages: 11-16

    • NAID

      40021714626

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The epigenetic regulation of CXCL14 plays a role in the pathobiology of oral cancers2017

    • Author(s)
      Ryuji Nakayama,Kazumune Arikawa,Ujjal K.Bhawal
    • Journal Title

      Journal of Cancer

      Volume: 8/ 15 Issue: 15 Pages: 3014-3027

    • DOI

      10.7150/jca.21169

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 介護保険施設における歯科訪問診療の実施による口腔機能等に対する効果2017

    • Author(s)
      和田康志, 川上智史,植原治,有川量崇,大久保一郎
    • Journal Title

      日本歯科医療管理学会雑誌

      Volume: 52/ 3 Pages: 130-141

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] The role of low-level sodium fluoride in periodontal inflammation2019

    • Author(s)
      Chieko Taguchi, Toshikazu Uchiyama, Fengzhu Zhang, Ujjal K Bhawal, Kazumune Arikawa
    • Organizer
      97th General Session & Exhibition of the IADR(国際学会)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sjogren’s syndrome in SATB1 conditional knockout mice2019

    • Author(s)
      Ujjal K Bhawal, Fengzhu Zhang, Yuriko Tanaka, Yumi Ito, Motonari Kondo, Kazumune Arikawa, Koichi Hiratsuka
    • Organizer
      第68回日本口腔衛生学会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] TGF-β1 induced Connexin43 promotes scar formation2019

    • Author(s)
      Xiaoyan Li, Ujjal K Bhawal, Lijia Guo, Yi Liu
    • Organizer
      第68回日本口腔衛生学会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低出力レーザー照射によるSTZ誘発糖尿病ラットのAGE-RAGE系に及ぼす影響2019

    • Author(s)
      田口 千恵子、内山 敏一、張 鳳洙、バワール ウジャール、有川 量崇
    • Organizer
      第68回日本口腔衛生学会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂質代謝異常が歯槽骨吸収に与える影響2018

    • Author(s)
      小林良喜, 瀧澤智美, 有川量崇, 田口千恵子, 後藤田宏也, 落合智子
    • Organizer
      日大口腔科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯科用チェアユニット給水システムにおけるナノバブル水の応用に関する研究2018

    • Author(s)
      田口千恵子, 有川量崇, 斎藤真規, 小林良喜, 内山敏一, 後藤田宏也, 落合智子, 金田隆
    • Organizer
      日大口腔科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Micromolar level of sodium fluoride promote osteoblast differentiation through Runx2 signaling2017

    • Author(s)
      Bhawal UK,Arikawa K,Taguchi C,Uchiyamma T,Hiratsuka K,Arakawa H,Nasu I
    • Organizer
      第66回日本口腔衛生学会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Basic helix-loop-helix transcription factors DEC1 and DEC2 modulates P.gingivalis-induced inflammation2017

    • Author(s)
      Bhawal UK,Suzuki M,Uchiyamma T,Arikawa K,Hiratsuka K,Shibutani K
    • Organizer
      Penn Periodontal Confernce
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of low-power laser irradiation in submandibullar glands of diabetes-induced rats2017

    • Author(s)
      Bhawal UK,Uchiyamma T,Arikawa K,Oka S,Hiratsuka K,,Hiratsuka K,Arakawa H,Nasu I,Shibutani K
    • Organizer
      IUPS38ht World Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 低出力レーザー照射によるSTZ誘発糖尿病ラットのAGE-RAGE系に及ぼす影響2017

    • Author(s)
      バワール ウジャール、有川量崇、内山敏一、平塚浩一、久保山昇、渋谷鑛
    • Organizer
      日本大学口腔科学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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