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Effects of nursing interventions increasing parasympathetic nervous activity in chronic disease patients

Research Project

Project/Area Number 17K12091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionIbaraki Christian University

Principal Investigator

Yamamoto Machiko  茨城キリスト教大学, 看護学部, 教授 (20295380)

Co-Investigator(Kenkyū-buntansha) 金子 健太郎  茨城キリスト教大学, 看護学部, 講師 (40714358)
尾形 優  茨城キリスト教大学, 看護学部, 講師 (10824732)
河野 かおり  獨協医科大学, 看護学部, 講師 (60619625)
桑原 正貴  東京大学, 大学院農学生命科学研究科(農学部), 教授 (30205273)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords副交感神経活動リザーブ / 積極的看護介入 / 慢性疾患患者
Outline of Final Research Achievements

This study aimed to evaluate the clinical effects of nursing interventions that enhance the parasympathetic nervous activity, focusing on the autonomic nervous activity in chronic disease patients and disease model animals. As the results, slow breathing exercise which consciously performs deep breathing as a nursing intervention, even in severe chronic kidney disease patients, increased parasympathetic nervous activity at rest, decreased diastolic blood pressure and promoted peripheral circulation. In addition, we found that the long-term effects of environmental enrichment were increased resting parasympathetic nervous activity and decreased heart rate in type 2 diabetic mice. In the future, we need to evaluate parasympathetic nervous activity in other chronic diseases and several severities. Furthermore, we also need to study the clinical effects of other nursing interventions.

Academic Significance and Societal Importance of the Research Achievements

安静時の副交感神経活動は生体に備えられている予備能防御機能を示しているといえ、我々は「副交感神経活動リザーブ」として捉えている。本研究成果は副交感神経活動リザーブを高める積極的な看護介入方法の確立につながり、生活の質の向上や健康寿命の観点などからしても新たな看護介入の発展に大きく寄与するものであった。
また、本研究で対象とした慢性腎臓病患者は近年罹患者数が増加しており、社会的にも大きな健康問題の一つである。したがって、本研究成果で示された慢性腎臓病患者の重症例における副交感神経活動リザーブの増大は社会的意義も大きなものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Effects of environmental enrichment on autonomic nervous activity in NSY mice2020

    • Author(s)
      Kentaro Kaneko, Akitoshi Chikamoto, Julia Chu-Ning Hsu, Ryota Tochinai, Shin-ichi Sekizawa, Machiko Yamamoto, Masayoshi Kuwahara
    • Journal Title

      Experimental Animals

      Volume: 69 Issue: 2 Pages: 161-167

    • DOI

      10.1538/expanim.19-0103

    • NAID

      130007835091

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Can slow breathing exercise improve the autonomic nervous imbalance in chronic kidney disease patients?2019

    • Author(s)
      Kentaro Kaneko, Shin-ichi Sekizawa, Ryota Tochinai, Machiko Yamamoto, Masayoshi Kuwahara
    • Organizer
      International Congress on Electrocardiology 2019, Joint meeting of ISHNE and ISE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can slow breathing exercise improve the autonomic nervous imbalance in chronic kidney disease patients ?2019

    • Author(s)
      Kentaro Kaneko, Shin-ichi Sekizawa, Ryota Tochinai, Machiko Yamamoto, Masayoshi Kuwahara
    • Organizer
      International Congress on Electrocardiology 2019, Joint meeting of ISHNE and ISE
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病モデルマウスにおける病態と自律神経系機能に及ぼす環境エンリッチメントの影響2018

    • Author(s)
      金子健太郎、近本明俊、関澤信一、山本真千子、桑原正貴
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of autonomic nervous functions in chronic kidney disease patients by tone-entropy analysis2017

    • Author(s)
      Kentaro Kaneko, Machiko Yamamoto, Masayoshi Kuwahara
    • Organizer
      The 44th International Congress on Electrocardiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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