| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Several prospective cohort studies suggested that milk might possibly have a preventive effect on colorectal cancer. In this study, the effect of extracellular vesicles (EVs) in bovine milk on growth activity of colon cancer cell line HT29 and tumorigenesis in colorectal carcinogenesis model were evaluated. As a result, milk EVs suppressed the growth activity of HT29 in a dose dependent manner possibly via cell cycle arrest at G1 phase. Furthermore, oral administration of milk EVs to colorectal carcinogenesis model mice tended to decrease the number of colorectal tumor.
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