Identification of Equol producing bacteria and Preventive effect of equol on the development of bladder dysfunction secondary to bladder outlet obstruction
| Project/Area Number |
17K12903
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エクオール / エクオール産生菌 / 植物性エストロゲン / 抗酸化作用 / 神経保護作用 / 過活動膀胱 / 大豆イソフラボン / 膀胱過活動 / 味噌 / 機能性食品 / 排尿障害 / 泌尿器科学 |
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| Outline of Final Research Achievements |
We identified the bacteria responsible for equol production in soybean miso, and it was a bacterium of the genus Pediococcus. We identified the equol producing gene possessed by this bacteria, but we could not confirmed equol production by the enzyme isolated from this bacteria. In addition, equol prevented the development of bladder dysfunction in rats with bladder outlet obstruction. It was suggested that the mechanism involves not only an antioxidative effect but also a neuroprotective effect.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでに報告のあるエクオール産生菌のほとんどが腸内細菌から単離されたものであるが、本研究では食品から単離している。そして食品から単離されたエクオール産生菌は機能性食品やプロバイオティクスへの応用が期待できる。またエクオールの機能として中枢神経における神経保護は培養細胞実験で報告があるが、動物を用いて膀胱内の神経（末梢神経）保護作用を示唆する報告はまだない。
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Report
(4 results)
Research Products
(1 results)
