| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Cleft palate is one of the most common congenital craniofacial anomalies in Japanese which is caused by genetic and environmental factors. However, the exact cause and mechanism of cleft palate has not yet been elucidated.
Pregnant mice were given a biotin-deficient diet and then were changed to a biotin-supplemented diet on day 10, 11 or 12 of gestation. The incidence of cleft palate was lower in the dg 10-supplemented group and the dg 11-supplemented group than the biotin-deficient group. It is suggested that biotin is necessary to develop and fuse the palatal process in mouse fetuses at midgestation (dg 11 and earlier). We speculated that biotin may play a role in the initial stage of palatal development.
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