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Sophistication of screening method for drugs of abuse by surface enhanced Raman spectroscopy

Research Project

Project/Area Number 17K12994
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social systems engineering/Safety system
Research InstitutionNational Research Institute of Police Science

Principal Investigator

Segawa Hiroki  科学警察研究所, 法科学第三部, 研究員 (80778978)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords表面増強ラマン散乱 / 薬物分析 / 規制薬物 / 金ナノ粒子 / スクリーニング / 法科学 / 法中毒学 / SERS / ラマン散乱 / ナノ粒子
Outline of Final Research Achievements

The purpose of this study is establishing basic knowledges and experimental protocols for applying surface-enhanced Raman scattering (SERS) spectroscopy to forensic drug analysis as a rapid screening method. For this purpose, optimization of the experimental protocol, clarifying the range of application, optimizing analytical protocols, and application to the pseudo- and real-samples were performed. The developed method could provide 10,000 times higher signal intensity than spontaneous Raman scattering, with simple experimental protocols. Various controlled drugs including stimulant, narcotics, hypnotics and new psychoactive substances could be observed by the developed SERS method. The controlled drugs could be detected from pseudo- and real-samples like beverages and herbal highs. These results show the possibility of the developed method as a rapid drug screening method.

Academic Significance and Societal Importance of the Research Achievements

規制対象となる薬物には、化学的な構造が類似した様々な物質が含まれている。そのため、科学的な証拠に基づいた客観的な薬物事犯の捜査を行うためには迅速かつ正確な薬物スクリーニングは重要である。本研究で開発した手法は簡便かつ高い識別能力を有していた。このことから、薬物スクリーニング法の一つの選択肢となる可能性を示すことができた。また、物質の構造に依存して信号強度に差がみられた。この構造と信号の相関はSERSの適用範囲を明らかにし、信号が発生するメカニズムを解明するための一助となることが期待された。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Rapid detection of hypnotics using surface-enhanced Raman scattering based on gold nanoparticle co-aggregation in a wet system2019

    • Author(s)
      Hiroki Segawa, Takao Fukuoka, Tamitake Itoh, Yuichi Imai, Yuko T Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
    • Journal Title

      ANALYST

      Volume: 144 Issue: 6 Pages: 2158-2165

    • DOI

      10.1039/c8an01829d

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of synthetic cannabinoids in herbal highs using surface-enhanced Raman scattering produced by gold nanoparticle co-aggregation in a wet system2019

    • Author(s)
      Segawa Hiroki、Fukuoka Takao、Itoh Tamitake、Imai Yuichi、Iwata Yuko T.、Yamamuro Tadashi、Kuwayama Kenji、Tsujikawa Kenji、Kanamori Tatsuyuki、Inoue Hiroyuki
    • Journal Title

      The Analyst

      Volume: 144 Issue: 23 Pages: 6928-6935

    • DOI

      10.1039/c9an01512d

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 表面増強ラマン散乱を用いた合成カンナビノイド類の簡易検出法の開発2019

    • Author(s)
      瀬川尋貴
    • Organizer
      日本法中毒学会第38年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Rapid detection of drugs of abuse by surface-enhanced Raman scattering spectroscopy based on gold nanoparticle co-aggregation2019

    • Author(s)
      Segawa Hiroki
    • Organizer
      10th International Conference on Advanced Vibrational Spectroscopy
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 表面増強ラマン散乱を用いた簡易薬物スクリーニング法の開発2018

    • Author(s)
      瀬川尋貴、福岡隆夫、伊藤民武、今井裕一、岩田祐子、山室匡史、桑山健次、辻川健治、金森達之、井上博之
    • Organizer
      日本法科学技術学会第24回学術集会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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