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Development of methods to control of energy metabolism with microstimulation of peripheral sympathetic nerve

Research Project

Project/Area Number 17K13011
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionYamagata University

Principal Investigator

Sato Daisuke  山形大学, 大学院医学系研究科, 助教 (60536960)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords末梢交感神経 / 糖取り込み / 機能的電気刺激 / 糖代謝 / 生活習慣病
Outline of Final Research Achievements

It has been reported that enhancement of peripheral glucose uptake via sympathetic nervous system. In the present study, I conducted electrical microstimulation of peripheral sympathetic nerve fascicle in the insulin-resistant high-fat-fed rats. As a result, the microstimulation tended to enhance glucose uptake without change in plasma insulin level. These results suggest that the artificial activation of sympathetic nervous system by the mictostimulation elevates glucose uptake independently of insulin secretion.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、インスリン抵抗性を有するラットであっても、末梢交感神経への電気刺激によって、インスリンとは独立に糖取り込みが亢進する可能性が示唆された。今後本研究は、作用メカニズムの解析を重ねた上で、交感神経系の人工的な賦活による糖代謝系の制御が可能な医療機器の開発へと繋がる可能性があり、将来的には運動や投薬によらない新たな糖尿病治療法の提案を目指している。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017

All Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 高脂肪食ラットの末梢交感神経活動に及ぼすSGLT2阻害剤の影響2019

    • Author(s)
      餘目譲太, 佐藤大介, 有坂拓真, 楠正隆, 中村孝夫
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット末梢交感神経電気刺激が糖取り込み能に及ぼす影響2019

    • Author(s)
      佐藤大介, 佐々木寛之, 楠正隆, 中村孝夫
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット末梢交感神経電気刺激が糖代謝系に及ぼす影響2019

    • Author(s)
      佐藤大介, 楠正隆, 中村孝夫
    • Organizer
      第20回山形医工学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Glucose load decreases peripheral sympathetic nerve activity in rats treated with SGLT2 inhibitor2018

    • Author(s)
      Sato D, Arisaka T, Sasaki H, Kusunoki M, Feng Z, Nakamura T
    • Organizer
      12th IDF-WPR Congress & 10th AASD Scientific Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrical microstimulation of peripheral sympathetic nerve fascicle enhances glucose uptake independently of insulin action in rats2017

    • Author(s)
      Sato D, Yamaguchi R, Suzuki R, Sasaki H, Kusunoki M, Feng Z, Nakamura T
    • Organizer
      International Society of Autonomic Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット末梢交感神経束へのmicrostimulationによる糖取り込み亢進効果2017

    • Author(s)
      鈴木遼, 山口陸, 佐藤大介, 楠正隆, 中村孝夫
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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