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Establishment of rat model in patellofemoral osteoarthritis and histopathological changes induced by mechanical load

Research Project

Project/Area Number 17K13051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKanazawa University

Principal Investigator

Takahashi Ikufumi  金沢大学, 附属病院, 理学療法士 (30743835)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords変形性膝関節症 / 関節軟骨 / 滑膜 / 膝蓋下脂肪体 / 非荷重環境 / 組織学 / 膝蓋大腿関節 / 膝蓋大腿関節症 / 理学療法 / 基礎研究 / メカニカルストレス
Outline of Final Research Achievements

The purpose of this study was to examine the following three things histologically.; ①Establishment of osteoarthritis (OA) rat model in patellofemoral joint induced by MIA, ②Effect of joint loading on the progression of OA, ③Effect of unloading environment on joint compoenents.
As a result, this study revealed the following findings.; ① Intra-articular injection of MIA induced the typical histological changes in the patellofemoral joint, ② Joint unloading inhibits articular cartilage degeneration in knee joint, ③ Unloading environment caused disuse histological changes in the articular cartilage, however, it caused no critical histological changes to the synovial membrane or infrapatellar fat pad.

Academic Significance and Societal Importance of the Research Achievements

本研究は「研究成果の概要」に述べた3つの点を組織学的に明らかにした。本研究で得られた新たな知見はいずれも理学療法分野で不足していた運動器における組織学的エビデンスを構築するものである。したがって、今後エビデンスに基づいた理学療法の確立に寄与するものであり、臨床上での治療に有益な知見であると考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(6 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results)

  • [Journal Article] Disuse histological changes of an unloading environment on joint components in rat knee joints Osteoarthritis and Cartilage Open.2019

    • Author(s)
      Takahashi I, Matsuzaki T, Kuroki H, Hoso M
    • Journal Title

      Osteoarthritis and Cartilage Open

      Volume: 1 Pages: 100008-100008

    • DOI

      10.1016/j.ocarto.2019.100008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Joint unloading inhibits articular cartilage degeneration in knee joints of a monosodium iodoacetate-induced rat model of osteoarthritis2019

    • Author(s)
      I. Takahashi, T. Matsuzaki, H. Kuroki, M. Hoso
    • Journal Title

      Osteoarthritis and cartilage

      Volume: In press Pages: 1084-1093

    • DOI

      10.1016/j.joca.2019.03.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term histopathological developments in knee-joint components in a rat model of osteoarthritis induced by monosodium iodoacetate2017

    • Author(s)
      Ikufumi Takahashi, Taro Matsuzaki, Masahiro Hoso
    • Journal Title

      J Phys Ther Sci

      Volume: 29 Issue: 4 Pages: 590-597

    • DOI

      10.1589/jpts.29.590

    • NAID

      130006789405

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ラット後肢免荷モデルにおいて非荷重環境がもたらす 関節軟骨の組織学的変化は膝関節コンパートメントご とに異なる2019

    • Author(s)
      高橋 郁文・松崎 太郎・黒木 裕士・細 正博
    • Organizer
      第24回日本基礎理学療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット変形性膝関節症モデルにおいて非荷重環境は変形性膝関節症の進行を抑制する2018

    • Author(s)
      高橋郁文、松崎太郎、黒木裕士、細正博
    • Organizer
      第6回日本運動器理学療法学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 薬物を用いたラット変形性膝関節症モデルにおける膝蓋大腿関節の病理組織学的変化2017

    • Author(s)
      高橋 郁文, 松崎 太郎, 細 正博
    • Organizer
      第52回日本理学療法学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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