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Combination of cell therapy and robotic rehabilitation for spinal cord injury

Research Project

Project/Area Number 17K13054
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

Takeshi Imura  広島大学, 医系科学研究科(保), 助教 (80760016)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords再生医療 / 間葉系幹細胞 / 脊髄損傷 / リハビリテーション / 細胞移植 / ロボット
Outline of Final Research Achievements

The purpose of this study was to determine optimal MSCs and investigate the effect of combination of MSCs transplantation and robotic rehabilitation in spinal cord injury. In the results, the gene expressions of Snail, Slug, Bdnf, and Gdnf were significantly higher in the MSCs derived from cranial bone. The expression of Vegf was significantly higher in the MSCs derived from adipose tissue. MSCs derived from cranial bone showed significant therapeutic effects in vivo experiment using spinal cord injury model and in vitro experiment using NG108-15 cells.

Academic Significance and Societal Importance of the Research Achievements

脊髄損傷は,運動障害および感覚障害を始めとする重篤な機能障害を残存することの多い疾患として知られているが,有効な治療法は未だに確立されていない.本研究において,脊髄損傷モデルに対し頭蓋骨由来MSCsの静脈内投与によって,優れた機能改善が得られることが明らかになった.治療効果の高いMSCsの供給組織が明らかになったことは脊髄損傷の新たな治療を検討する中で意義があるものと考える.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats2020

    • Author(s)
      OSHITA Jumpei、OKAZAKI Takahito、MITSUHARA Takafumi、IMURA Takeshi、NAKAGAWA Kei、OTSUKA Takashi、KUROSE Tomoyuki、TAMURA Takayuki、ABIKO Masaru、TAKEDA Masaaki、KAWAHARA Yumi、YUGE Louis、KURISU Kaoru
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 60 Issue: 2 Pages: 83-93

    • DOI

      10.2176/nmc.oa.2019-0186

    • NAID

      130007798580

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats.2019

    • Author(s)
      Kurose T, Takahashi S, Otsuka T, Nakagawa K, Imura T, Sueda T, Yuge L
    • Journal Title

      Stem Cell Res

      Volume: 41 Pages: 1-8

    • DOI

      10.1016/j.scr.2019.101601

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] “Microgravity” as a unique and useful stem cell culture environment for cell-based therapy.2019

    • Author(s)
      Imura T., Otsuka T., Kawahara Y., Yuge L.
    • Journal Title

      Regene Ther

      Volume: 12 Pages: 2-5

    • DOI

      10.1016/j.reth.2019.03.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Interactive effects of cell therapy and rehabilitation in brain injury model2018

    • Author(s)
      Takeshi Imura
    • Organizer
      World Congress of the Tissue Engineering and Regenerative Medicine International Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic mechanisms of myoblast differentiation in hypergravity culture2018

    • Author(s)
      Takeshi Imura
    • Organizer
      American Society for Gravitational and Space Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷モデルラットに対するヒト頭蓋骨由来間葉系幹細胞の移植効果2018

    • Author(s)
      城戸皓輝、猪村剛史
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cranial bone derived mesenchymal stem cells cultured in simulated microgravity have highly neuroprotective effect against stress induced NG108-15 cell death in vitro.2017

    • Author(s)
      Takashi Otsuka, Takeshi Imura
    • Organizer
      15th International Society for Stem Cell Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Myogenic differentiation is accelerated by hypergravity culture through epigenetic regulations.2017

    • Author(s)
      Takeshi Imura
    • Organizer
      33rd American Society for Gravitational and Space Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulated microgravity culture increases the neuroprotective potential of mesenchymal stem cells.2017

    • Author(s)
      Louis Yuge, Takashi Otsuka, Takeshi Imura
    • Organizer
      33rd American Society for Gravitational and Space Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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