Verification of the effects of rehabilitation on neural circuit reorganization in motor cortex.
| Project/Area Number |
17K13067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Keio University |
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Principal Investigator |
Kondo Takahiro 慶應義塾大学, 医学部(信濃町), 特任助教 (70759886)
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| Research Collaborator |
USHIBA Junichi
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | マーモセット / カルシウムイメージング / 脊髄損傷 / 運動制御 / リハビリテーション / 脳深部カルシウムイメージング / 神経科学 |
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| Outline of Final Research Achievements |
The plasticity of neuronal activity was examined in a rat corticospinal tract injury model. 208 ± 7.2 neuronal activities were recorded in the motor cortex. Neural activity in the rat motor cortex during arm reaching movements was recorded, and 12.7 cells (6.1%) were found to be active in association with reaching movements. It was confirmed that the number of these nerve cells related to reaching movement decreased 1 -2 weeks after injury and increased thereafter. Similarly, in the marmoset motor area, it was confirmed that neurons mobilized before, immediately after (paralysis), and during recovery from corticospinal tract injury changed.
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| Academic Significance and Societal Importance of the Research Achievements |
この内視鏡レンズを用いた観察手法は、より脳の深部に位置する大脳基底核や海馬などの領域における観察にも応用が可能であり、運動や認知、記憶などの霊長類における複雑な脳機能に関わる神経ネットワークの研究の有力なツールとなる。さらに精神・神経疾患モデルマーモセットに対し適用することで、ヒトにおける精神・神経疾患の新たな治療へ展開されることが期待されます。
リハビリテーションは様々なメカニズムが複合的に合わせることで運動機能回復に寄与するが、本研究ではその中でも脊髄損傷後に局所回路の再編成がどのように起こるかIn vivo カルシウムイメージング手法を用いて解析することができた。
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys2018
Author(s)
Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, *Ushiba J, *Okano H
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Journal Title
Cell Rep
Volume: 24(8)
Issue: 8
Pages: 2191-2195
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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