A study for the mechanism of exercise therapy to promote the motor functional recovery after brain injury.

• Project/Area Number: 17K13069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Showa University
• Principal Investigator: YOSHIKAWA Akira 昭和大学, 医学部, 助教 (90737355)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 脳損傷 / 運動 / 運動機能障害 / 運動機能回復 / 動作分析 / 代謝 / 皮質脊髄路 / 遺伝子 / 運動負荷 / 機能回復 / 運動療法

Outline of Final Research Achievements

Exercise therapy is one of the methods for motor functional recovery with brain injury patients. The purpose of this study was to clarify the mechanism of motor function recovery. It was kinematically revealed that the exercise promoted the changes in motor function on the paretic side. In addition, physiological and morphological changes in the nerves and skeletal muscles were also detected. It was found that exercise induces not only changes in neural networks but also changes in skeletal muscles. From this reason, it was suggested that exercise leads to recovery of motor function.

Academic Significance and Societal Importance of the Research Achievements

本研究は、脳損傷患者の運動機能障害からの回復と社会復帰に向けた基盤研究である。本研究では、モデル動物を用いて定量化された運動課題を行うことで、運動機能の変化を運動学的に現すことができた。さらに運動学的に表現された運動機能を司る神経および骨格筋の変化も明らかにすることができた。これらの結果は、運動療法の運動機能を回復させるメカニズムの解明に寄与するとともに動物からヒトへの橋渡し研究にも波及することが期待される意義のある結果である。

Research Products

• [Journal Article] 学会印象記 Neuroscience 2019(2019年10月19〜23日,シカゴ) (2020)
  • Author(s): 吉川 輝
  • Journal Title: BRAIN and NERVE Volume: 72 Issue: 2 Pages: 171-173
  • DOI: 10.11477/mf.1416201498
  • NAID: 40022160825
  • ISSN: 1344-8129, 1881-6096
  • Year and Date: 2020-02-01
  • Open Access
• [Journal Article] Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction (2020)
  • Author(s): Morishita Saho、Hokamura Kazuya、Yoshikawa Akira、Agata Nobuhide、Tsutsui Yoshihiro、Umemura Kazuo、Kumada Tatsuro
  • Journal Title: Brain and Behavior Volume: 10 Issue: 3 Pages: 1535-1535
  • DOI: 10.1002/brb3.1535
  • Peer Reviewed / Open Access
• [Journal Article] Association between Odor Memory and Prefrontal Cortex : An fMRI Study [Presidential Award Proceedings] (2019)
  • Author(s): MASAOKA Yuri、WATANABE Keiko、IDA Masahiro、YOSHIDA Masaki、KOIWA Nobuyoshi、YOSHIKAWA Akira、KUBOTA Satomi、IIZUKA Natsuko、KAWAMURA Mitsuru、ONO Kenjiro、IZUMIZAKI Masahiko
  • Journal Title: Japanese Journal of Magnetic Resonance in Medicine Volume: 39 Issue: 2 Pages: 63-64
  • DOI: 10.2463/jjmrm.2018-1662
  • NAID: 130007664831
  • ISSN: 0914-9457, 2434-0499
  • Year and Date: 2019-05-15
  • Open Access
• [Journal Article] OPTOGENETIC ANALYSIS OF THE DESCENDING PAIN INHIBITORY SYSTEM VIA 5-HT NEURONS IN THE NUCLEUS RAPHE MAGNUS (2019)
  • Author(s): 三橋 学、金丸 みつ子、田中 謙二、吉川 輝、稲垣 克記、久光 正、砂川 正隆、泉﨑 雅彦
  • Journal Title: Journal of The Showa University Society Volume: 79 Issue: 4 Pages: 483-491
  • DOI: 10.14930/jshowaunivsoc.79.483
  • NAID: 130007768992
  • ISSN: 2187-719X, 2188-529X
  • Peer Reviewed
• [Journal Article] Optogenetic Stimulation of 5-HT Neurons in the Median Raphe Nucleus Affects Anxiety and Respiration (2019)
  • Author(s): OKUMA Naoki、KANAMARU Mitsuko、MORIYA Rika、TANAKA Kenji、ARATA Satoru、WATANABE Jun、YOSHIKAWA Akira、IZUMIZAKI Masahiko
  • Journal Title: The Showa University Journal of Medical Sciences Volume: 31 Issue: 3 Pages: 263-274
  • DOI: 10.15369/sujms.31.263
  • NAID: 130007742535
  • ISSN: 0915-6380, 2185-0968
  • Peer Reviewed / Open Access
• [Journal Article] Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Frontiers in Psychology (2018)
  • Author(s): Watanabe K, Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Ida M, Ono K, Izumizaki M
  • Journal Title: Frontiers in Psychology Volume: 9 Pages: 687-687
  • DOI: 10.3389/fpsyg.2018.00687
  • Peer Reviewed / Open Access
• [Presentation] Resting-State fMRI Connectivity Analysis between Hippocampus and Motor area in COPD patients (2020)
  • Author(s): Akira Yoshikawa, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Satomi Kubota, Ryo Manabe, Honma Motoyasu, Natsuko Iizuka, Masahiro Ida, Masahiko Izumizaki
  • Organizer: 第97回日本生理学会大会
• [Presentation] Detection of motor defects in hindlimbs during locomotion in rats with focal cerebral infarction by 3D kinematical analysis (2020)
  • Author(s): Tatsuro Kumada, Akira Yoshikawa, Saho Morishita, Kazuya Hokamura, Masahiko Izumizaki, Kazuo Umemura
  • Organizer: 第97回日本生理学会大会
• [Presentation] Network analysis of functional brain connectivity between hippocampus and motor area in COPD patients (2019)
  • Author(s): Akira Yoshikawa, Masahiro Ida, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Satomi Kubota, Ryo Manabe, Honma Motoyasu, Natsuko Iizuka, Masahiko Izumizaki
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Exercise improves contractile force and kinematical movement of paralyzed hindlimb after brain damage of mice (2019)
  • Author(s): Akira Yoshikawa, Hirokazu Ohtaki, Masahiko Izumizaki
  • Organizer: Neuroscience 2019
  • Int'l Joint Research
• [Presentation] 痙縮を再現する神経筋骨格モデル (2019)
  • Author(s): 長谷 和徳, 的場 斗吾, 吉川 輝, 金 承革
  • Organizer: 第26回バイオメカニズム・シンポジウム
• [Presentation] 3次元神経筋骨格モデルによる脳性麻痺歩行の再現 (2019)
  • Author(s): 湯本 良輔, 長谷 和徳, 吉田 真, 金 承革, 吉川 輝
  • Organizer: 第40回バイオメカニズム学術講演会
• [Presentation] 大脳皮質感覚運動領域における限局的脳梗塞モデルラットの運動学的な歩行分析 (2019)
  • Author(s): 吉川輝, 森下紗帆, 外村和也, 梅村和夫, 大滝博和, 泉﨑雅彦, 熊田竜郎
  • Organizer: 第24回日本基礎理学療法学会学術大会
• [Presentation] Relationship between Resting-State Functional Connectivity and cognitive function. (2019)
  • Author(s): Yoshikawa Akira, Masaoka Yuri, Yoshida Masaki, Koiwa Nobuyoshi, Kubota Satomi, Manabe Ryo, Natsuko Iizuka, Ida Masahiro, Izumizaki Masahiko
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Three-dimensional kinematical gait analysis of hindlimbs in rats with focal cerebral infarction. (2019)
  • Author(s): Tatsuro Kumada, Akira Yoshikawa, Saho Morishita, Kazuya Hokamura, Masahiko Izumizaki, Kazuo Umemura
  • Organizer: he 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Relation between Montreal Cognitive Assessment and amygdala-hippocampus volumes in the elderly. (2019)
  • Author(s): Satomi Kubota, Yuri Masaoka, Masaki Yoshida, Ryuta Kinno, Akira Yoshikawa, Ryo Manabe, Natsuko Iizuka, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Hippocampus abnormalities evaluated by density imaging in COPD patients. (2019)
  • Author(s): Natsuko Iizuka, Yuri Masaoka, Ryo Manabe, Masaki Yoshida, Koji Kamagata, Yuki Takenaka, Kentaro Okuda, Akira Yoshikawa, Satomi Kubota, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Effects of optogenetic inhibition of 5-HT neurons in the dorsal raphe nucleus on respiratory control. (2019)
  • Author(s): Mitsuko Kanamaru, Mana Tsukada, Akira Yoshikawa, Hiroshi Onimaru, Ayako Mochizuki, Masataka Sunagawa, Tomio Inoue, Masahiko Izumizaki
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] 安静時機能的磁気共鳴画像における呼吸、心拍の影響. (2018)
  • Author(s): 吉川輝, 政岡ゆり, 吉田正樹, 小岩信義, 久保田怜美, 眞鍋亮, 飯塚奈都子, 井田正博,泉﨑雅彦
  • Organizer: 第25回脳機能とリハビリテーション研究会学術集会
• [Presentation] efault mode network and cognitive function: investigating into resting-state functional connectivity between hemisphere. (2018)
  • Author(s): Akira Yoshikawa, Masahiro Ida, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Satomi Kubota, Ryo Manabe, Natsuko Iizuka, Masahiko Izumizaki
  • Organizer: 第46 回日本磁気共鳴医学会大会
• [Presentation] Association between odor memory and prefrontal cortex: an fMRI study. (2018)
  • Author(s): Yuri Masaoka, Keiko Watanabe, Masahiro Ida, Masaki Yoshida, Nobuyoshi Koiwa, Akira Yoshikawa, Satomi Kubota, Natsuko Iizuka, Mitsuru Kawamura, Kenjirou Ono, Masahiko Izumizaki
  • Organizer: 第46 回日本磁気共鳴医学会大会
• [Presentation] Amygdala reduction could be an early indication for cognitive impairment in elderly subjects. (2018)
  • Author(s): Satomi Kubota, Yuri Masaoka, Masaki Yoshida, Ryuta Kinno, Akira Yoshikawa, Ryo Manabe, Natsuko Iizuka, Masahiro Ida, Kenjirou Ono, Masahiko Izumizaki
  • Organizer: 第46 回日本磁気共鳴医学会大会
• [Presentation] Cognitive function and morphological brain changes in chronic obstructive pulmonary disease. (2018)
  • Author(s): Ryo Manabe, Yuri Masaoka, Kentaro Okuda, Masaki Yoshida, Akira Yoshikawa, Satomi Kubota, Haruna Sato, Hitomi Ida, Masahiro Ida, Hironori Sagara, Masahiko Izumizaki
  • Organizer: 第46 回日本磁気共鳴医学会大会
• [Presentation] Graph theoretical analysis of functional brain network for abnormal binocular function. (2018)
  • Author(s): Masaki Yoshida, Masahiro Ida, Yuri Masaoka, Nobuyuki Koiwa, Akira Yoshikawa.
  • Organizer: 第46 回日本磁気共鳴医学会大会
• [Presentation] Three-dimensional kinematic evaluation of motor deficit in a rat model of photochemically induced focal stroke. (2018)
  • Author(s): Akira Yoshikawa, Saho Morishita, Kazuya Hokamura, Kazuo Umemura, Masahiko Izumizaki, Tatsuro Kumada
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Odor induced autobiographical memory associated with slow breathing and medial prefrontal activity: fMRI study. (2018)
  • Author(s): Yuri Masaoka, Keiko Watanabe, Mitsuru Kawamura, Masaki Yoshida, Nobuyoshi Koiwa, Akira Yoshikawa, Satomi Kubota, Masahiro Ida, Kenjirou Ono, Masahiko Izumizaki
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] 胸髄損傷不全麻痺患者の片脚立位保持及び歩行特性. (2018)
  • Author(s): 金承革，吉川輝，栗田泰成，河戸誠司
  • Organizer: 第40回臨床歩行分析研究会定例会
• [Presentation] 3次元神経筋骨格モデルを用いた痙性歩行の治療評価 (2018)
  • Author(s): 的場斗吾, 小野智貴, 長谷和徳, 吉田真, 金承革，吉川輝
  • Organizer: 第39回バイオメカニズム学術講演会
• [Presentation] COPD患者における脳の構造性変化について. (2018)
  • Author(s): 眞鍋亮, 政岡ゆり, 奥田健太郎, 吉田正樹, 吉川輝, 久保田怜美, 井田瞳, 井田正博, 相良博典, 泉崎雅彦
  • Organizer: 第28回日本呼吸ケア・リハビリテーション学会学術集会
• [Presentation] 地域在住の健康高齢者を対象とした嗅覚機能と認知機能の関係性 -安静時機能的磁気共鳴画像法を用いた機能的接続性解析- (2018)
  • Author(s): 吉川輝, 政岡ゆり, 吉田正樹, 小岩信義, 久保田怜美, 眞鍋亮, 飯塚奈都子, 井田正博,泉﨑雅彦
  • Organizer: 第5回日本地域理学療法学会学術大会
• [Presentation] マウスにおける漸増運動負荷中の呼吸・代謝応答の加齢に伴う変化. (2018)
  • Author(s): 吉川輝, 金丸みつ子, 飯塚眞喜人, 大滝博和, 泉﨑雅彦
  • Organizer: 第23回日本基礎理学療法学会学術大会
• [Presentation] Relationship between the Functional Connectivity during resting-state fMRI and Cognitive Assessment Battery in elderly subjects (2018)
  • Author(s): Yoshikawa Akira, Masaoka Yuri, Yoshida Masaki, Koiwa Nobuyoshi, Kubota Satomi, Manabe Ryo, Ida Masahiro, Izumizaki Masahiko
  • Organizer: 第95回日本生理学会大会
• [Presentation] Effect of different exercises on the differentiation of neural stem cells and motor recovery in rats with motor cortex infarction (2018)
  • Author(s): Saho Morishita, Kazuya Hokamura, Akira Yoshikawa, Nobuhide Agata, Kazuo Umemura, Yoshihiro Tsutsui, Tatsuro Kumada
  • Organizer: 第95回日本生理学会大会
• [Presentation] ptogenetic analysis of nociceptive mechanism mediated by 5-HT neurons in the nucleus raphe magnus (2018)
  • Author(s): Mitsuhashi Manabu, Kanamaru Mitsuko, Tanaka F. Kenji, Yoshikawa Akira, Hisamitsu Tadashi, Sunagawa Masataka, Izumizaki Masahiko
  • Organizer: 第95回日本生理学会大会
• [Presentation] Cognitive function and hippocampus volume in chronic obstructive pulmonary disease (2018)
  • Author(s): Ryo Manabe, Yuri Masaoka, Kentaro Okuda, Masaki Yoshida, Akira Yoshikawa, Satomi Kubota, Haruna Sato, Hitomi Yamagami, Masahiro Ida, Hironori Sagara, Masahiko Izumizaki
  • Organizer: 第95回日本生理学会大会
• [Presentation] Amygdala reduction could be an early indication for cognitive impairment in elderly subjects (2018)
  • Author(s): Kubota Satomi, Masaoka Yuri, Yoshida Masaki, Kinno Ryuta, Yoshikawa Akira, Manabe Ryo, Ida Masahiro, Ono Kenjirou, Izumizaki Masahiko
  • Organizer: 第95回日本生理学会大会
• [Presentation] 片側大脳皮質損傷後の運動機能回復に関与する神経回路網の再編成 - 神経回路網の再編成を調節する遺伝子の探索 - (2017)
  • Author(s): 吉川輝，中町智哉，Rakwal Randeep，柴藤淳子，大滝博和，塩田清二，泉﨑雅彦
  • Organizer: 第52回日本理学療法学術大会
• [Presentation] Three-dimensional neuro-musculo-skeltal model with mechanical charcteristics of stretch reflex (2017)
  • Author(s): MATOBA Togo, HASE Kazunori, KIM Sung Hyek, YOSHIKAWA Akira
  • Organizer: XXVI Congress of the International Society of Biomechanics
  • Int'l Joint Research
• [Presentation] 各測定方法から見た健康・運動について - ヒト及びモデル動物を用いて運動生理学的観点から見た運動と健康 - (2017)
  • Author(s): 吉川輝
  • Organizer: 日本スポーツ健康科学学会 第５回大会
  • Invited
• [Presentation] The Influence of Physiological Noise on Default Mode Network - resting state fMRI Study - (2017)
  • Author(s): Yoshikawa Akira, Ida Masahiro, Yoshida Masaki, Masaoka Yuri, Koiwa Nobuyoshi, Watanabe Keiko, Kubota Satomi, Manabe Ryo, Izumizaki Masahiko
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Sleep disorder or deficit in olfaction provide an early indication of neurodegeneration (2017)
  • Author(s): Masaoka Yuri, Ida Masahiro, Yoshida Masaki, Koiwa Nobuyoshi, Yoshikawa Akira, Kubota Satomi, Kawamura Mitsuru, Ono Kenjiro, Izumizaki Masahiko.
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Graph theoretical analysis of white matter network for abnormal binocular function (2017)
  • Author(s): Yoshida Masaki, Ida Masahiro, Masaoka Yuri, Yoshikawa Akira
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] 痙性歩行の再現を目指した3次元神経筋骨格モデルの構築 (2017)
  • Author(s): 的場斗吾、長谷和徳、林祐一郎、金承革、吉川輝
  • Organizer: 第38回バイオメカニズム学術講演会
• [Presentation] Cardiac and Respiratory Physiological Noise Corrections Improved Resting-State Functional Connectivity in the Limbic Areas (2017)
  • Author(s): Akira Yoshikawa, Masaki Yoshida, Yuri Masaoka, Nobuyoshi Koiwa, Keiko Watanabe, Masahiro Ida, Masahiko Izumizaki
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Effects of various exercises on motor recovery through gating and neuro/gliogenesis in motor cortex infarction in rats (2017)
  • Author(s): Tatsuro Kumada, Saho Morishita, Kazuya Hokamura, Akira Yoshikawa, Nobuhide Agata, Yoshihiro Tsutsui. Kazuo Umemura
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Olfactory impairment and sleep disorder may provide early indication of neurodegeneration (2017)
  • Author(s): Masaoka Yuri, Kawamura Mitsuru, Yoshida Masaki, Koiwa Nobuyoshi, Yoshikawa Akira, Ida Masahiro, Ono Kenjiro, A. Phillips, Izumizaki Masahiko
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Remarks] 昭和大学 医学部 生理学講座 生体調節機能学部門
  • URL: https://www.showa-u.ac.jp/education/med/major/physio-2.html
• [Remarks] 昭和大学 医学部 生理学講座 生体調節機能学部門
  • URL: http://www.showa-u.ac.jp/sch/med/major/physiol2/index.html