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Approaches toward modulating motor ability utilizing convenient and non-invasive neuromodulation

Research Project

Project/Area Number 17K13112
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionWaseda University (2019-2021)
The University of Tokyo (2017-2018)

Principal Investigator

Nakagawa Kento  早稲田大学, スポーツ科学学術院, 講師(任期付) (80735457)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords静磁場刺激 / 筋腹刺激 / リハビリテーション / H反射 / 運動単位 / 運動前野 / MRI / 神経活動修飾 / motor variability / 力発揮のばらつき / TMS / 脊髄運動ニューロン / 一次運動野 / 静磁場 / 力調節 / 脊髄 / 反射
Outline of Final Research Achievements

The present study has been performed to test the effect of new neuromodulation techniques including transcranial static magnetic field stimulation (tSMS) and the mechanism of motor point stimulation on the neural excitability and motor ability. We found that 1) tSMS on primary motor cortex (M1) but not premotor cortex impairs the control ability of ballistic force production. Further, 2) motor point stimulation efficiently and electively activates motor nerve with less activating Ia sensory nerve, and motor unit recruitment pattern of was inverse of the size principle.

Academic Significance and Societal Importance of the Research Achievements

脊髄損傷などの運動機能障害に対するニューロリハビリテーション手法は、多くの臨床現場で実施できるよう、簡便かつ低価格なものが求められる。本研究で用いた静磁場刺激や筋腹への電気刺激は、高価な機材を必要としないため、幅広い臨床現場で用いられることが期待される。本研究では静磁場刺激が運動機能に影響を及ぼすことを世界で初めて実証した。プロトコルを更に検討していけばリハビリ現場にも容易に用いることができるであろう。筋腹電気刺激については、既にリハビリに用いられている手法であるが、今回そのメカニズムの一端が解明されたため、エビデンスをもってリハビリ応用が期待される。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019 2018

All Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 11 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Development of a Coaching System for Functional Electrical Stimulation Rowing: A Feasibility Study in Able-Bodied Individuals2022

    • Author(s)
      Tajali Shirin、Fok Kai Lon、Theventhiran Pirashanth、Ye Gongkai、Yokoyama Hikaru、Nakagawa Kento、Masani Kei
    • Journal Title

      Sensors

      Volume: 22 Issue: 5 Pages: 1813-1813

    • DOI

      10.3390/s22051813

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intra-limb modulations of posterior root-muscle reflexes evoked from the lower-limb muscles during isometric voluntary contractions2021

    • Author(s)
      Saito Akira、Nakagawa Kento、Masugi Yohei、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 239 Issue: 10 Pages: 3035-3043

    • DOI

      10.1007/s00221-021-06187-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determinants of Neural Plastic Changes Induced by Motor Practice2021

    • Author(s)
      Dai Wen、Nakagawa Kento、Nakajima Tsuyoshi、Kanosue Kazuyuki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 613867-613867

    • DOI

      10.3389/fnhum.2021.613867

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inter-muscle differences in modulation of motor evoked potentials and posterior root-muscle reflexes evoked from lower-limb muscles during agonist and antagonist muscle contractions2020

    • Author(s)
      Saito Akira、Nakagawa Kento、Masugi Yohei、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 239 Issue: 2 Pages: 463-474

    • DOI

      10.1007/s00221-020-05973-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor point stimulation primarily activates motor nerve2020

    • Author(s)
      Nakagawa Kento、Bergquist Austin J.、Yamashita Taro、Yoshida Takashi、Masani Kei
    • Journal Title

      Neuroscience Letters

      Volume: 736 Pages: 135246-135246

    • DOI

      10.1016/j.neulet.2020.135246

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor Point Stimulation in Spinal Paired Associative Stimulation can Facilitate Spinal Cord Excitability2020

    • Author(s)
      Fok Kai Lon、Kaneko Naotsugu、Sasaki Atsushi、Nakagawa Kento、Nakazawa Kimitaka、Masani Kei
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 14 Pages: 593806-593806

    • DOI

      10.3389/fnhum.2020.593806

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cortical reorganization of lower-limb motor representations in an elite archery athlete with congenital amputation of both arms2020

    • Author(s)
      Nakagawa K, Takemi M, Nakanishi T, Sasaki A, Nakazawa K.
    • Journal Title

      NeuroImage: Clinical

      Volume: 25 Pages: 102144-102144

    • DOI

      10.1016/j.nicl.2019.102144

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Remarkable hand grip steadiness in individuals with complete spinal cord injury2019

    • Author(s)
      Nakanishi T, Kobayashi H, Obata H, Nakagawa K, Nakazawa K.
    • Journal Title

      Experimental Brain Research

      Volume: 237 Issue: 12 Pages: 3175-3183

    • DOI

      10.1007/s00221-019-05656-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional plasticity of the ipsilateral primary sensorimotor cortex in an elite long jumper with below-knee amputation2019

    • Author(s)
      Mizuguchi N*, Nakagawa K*, Tazawa Y, Kanosue K, Nakazawa K. (* Equal contribution)
    • Journal Title

      NeuroImage: Clinical

      Volume: 23 Pages: 101847-101847

    • DOI

      10.1016/j.nicl.2019.101847

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy in Pinch Force Control Can Be Altered by Static Magnetic Field Stimulation Over the Primary Motor Cortex.2019

    • Author(s)
      Nakagawa K, Sasaki A, Nakazawa K.
    • Journal Title

      Neuromodulation

      Volume: in press Issue: 8 Pages: 12912-12912

    • DOI

      10.1111/ner.12912

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Repeatability of spinal reflexes of lower limb muscles evoked by transcutaneous spinal cord stimulation2019

    • Author(s)
      Saito A, Masugi Y, Nakagawa K, Obata H, Nakazawa K.
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 4 Pages: e0214818-e0214818

    • DOI

      10.1371/journal.pone.0214818

    • NAID

      120006800703

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Static magnetic field stimulation applied over the cervical spinal cord can decrease corticospinal excitability in finger muscle2018

    • Author(s)
      Nakagawa K., Nakazawa K.
    • Journal Title

      Clinical Neurophysiology Practice

      Volume: 3 Pages: 49-53

    • DOI

      10.1016/j.cnp.2018.02.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Different motor unit recruitment pattern between peripheral nerve stimulation and motor point stimulation.2019

    • Author(s)
      Nakagawa K, Fok KL, Masani K.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of transcranial static magnetic field stimulation over primary motor cortex on pinching force control2018

    • Author(s)
      Nakagawa K, Nakazawa K
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of SMS on motor function and spinal neural circuit excitability2018

    • Author(s)
      Nakagawa K.
    • Organizer
      The 1st International Workshop for Static Magnetic Stimulation
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2024-12-25  

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